| Malonate-semialdehyde dehydrogenase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 1.2.1.15 | ||||||||
| CAS no. | 9028-94-8 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
In enzymology, a malonate-semialdehyde dehydrogenase (EC 1.2.1.15) is an enzyme that catalyzes the chemical reaction
- 3-oxopropanoate + NAD(P)+ + H2O malonate + NAD(P)H + 2 H+
The 4 substrates of this enzyme are 3-oxopropanoate, NAD+, NADP+, and H2O, whereas its 4 products are malonate, NADH, NADPH, and H+.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 3-oxopropanoate:NAD(P)+ oxidoreductase. This enzyme participates in beta-alanine metabolism.
References[edit]
- Nakamura K, Bernheim F (June 1961). "Studies on malonic semialdehyde dehydrogenase from Pseudomonas aeruginosa". Biochimica et Biophysica Acta. 50: 147–52. doi:10.1016/0006-3002(61)91071-X. PMID 13727610.
