Protein-coding gene in the species Homo sapiens
A-kinase anchor protein 5 is a protein that in humans is encoded by the AKAP5 gene .[5] [6] [7]
Function [ edit ]
The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene is intronless and encodes a member of the AKAP family. The encoded protein binds to the RII-beta regulatory subunit of PKA, and also to protein kinase C and the phosphatase calcineurin . It is predominantly expressed in cerebral cortex and may anchor the PKA protein at postsynaptic densities (PSD) and be involved in the regulation of postsynaptic events. It is also expressed in T lymphocytes and may function to inhibit interleukin 2 transcription by disrupting calcineurin-dependent dephosphorylation of NFAT .[7]
Interactions [ edit ]
AKAP5 has been shown to interact with:
References [ edit ]
^ a b c GRCh38: Ensembl release 89: ENSG00000179841 – Ensembl , May 2017
^ a b c GRCm38: Ensembl release 89: ENSMUSG00000021057 – Ensembl , May 2017
^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Carr DW, Stofko-Hahn RE, Fraser ID, Cone RD, Scott JD (Sep 1992). "Localization of the cAMP-dependent protein kinase to the postsynaptic densities by A-kinase anchoring proteins. Characterization of AKAP 79" . J Biol Chem . 267 (24): 16816–23. doi :10.1016/S0021-9258(18)41856-X . PMID 1512224 .
^ Carr DW, Hausken ZE, Fraser ID, Stofko-Hahn RE, Scott JD (Aug 1992). "Association of the type II cAMP-dependent protein kinase with a human thyroid RII-anchoring protein. Cloning and characterization of the RII-binding domain" . J Biol Chem . 267 (19): 13376–82. doi :10.1016/S0021-9258(18)42221-1 . PMID 1618839 .
^ a b "Entrez Gene: AKAP5 A kinase (PRKA) anchor protein 5" .
^ Kashishian A, Howard M, Loh C, Gallatin WM, Hoekstra MF, Lai Y (Oct 1998). "AKAP79 inhibits calcineurin through a site distinct from the immunophilin-binding region" . J. Biol. Chem . 273 (42): 27412–9. doi :10.1074/jbc.273.42.27412 . PMID 9765270 .
^ Brandon NJ, Jovanovic JN, Colledge M, Kittler JT, Brandon JM, Scott JD, Moss SJ (Jan 2003). "A-kinase anchoring protein 79/150 facilitates the phosphorylation of GABA(A) receptors by cAMP-dependent protein kinase via selective interaction with receptor beta subunits". Mol. Cell. Neurosci . 22 (1): 87–97. doi :10.1016/s1044-7431(02)00017-9 . PMID 12595241 . S2CID 6172436 .
External links [ edit ]
Further reading [ edit ]
Lester LB, Scott JD (1997). "Anchoring and scaffold proteins for kinases and phosphatases". Recent Prog. Horm. Res . 52 : 409–29, discussion 429–30. PMID 9238861 .
Michel JJ, Scott JD (2002). "AKAP mediated signal transduction". Annu. Rev. Pharmacol. Toxicol . 42 : 235–57. doi :10.1146/annurev.pharmtox.42.083101.135801 . PMID 11807172 .
Hirsch AH, Glantz SB, Li Y, et al. (1992). "Cloning and expression of an intron-less gene for AKAP 75, an anchor protein for the regulatory subunit of cAMP-dependent protein kinase II beta" . J. Biol. Chem . 267 (4): 2131–4. doi :10.1016/S0021-9258(18)45852-8 . PMID 1733921 .
Carr DW, Stofko-Hahn RE, Fraser ID, et al. (1991). "Interaction of the regulatory subunit (RII) of cAMP-dependent protein kinase with RII-anchoring proteins occurs through an amphipathic helix binding motif" . J. Biol. Chem . 266 (22): 14188–92. doi :10.1016/S0021-9258(18)98665-5 . PMID 1860836 .
Coghlan VM, Perrino BA, Howard M, et al. (1995). "Association of protein kinase A and protein phosphatase 2B with a common anchoring protein". Science . 267 (5194): 108–11. Bibcode :1995Sci...267..108C . doi :10.1126/science.7528941 . PMID 7528941 .
Glantz SB, Li Y, Rubin CS (1993). "Characterization of distinct tethering and intracellular targeting domains in AKAP75, a protein that links cAMP-dependent protein kinase II beta to the cytoskeleton" . J. Biol. Chem . 268 (17): 12796–804. doi :10.1016/S0021-9258(18)31458-3 . PMID 8509414 .
Faux MC, Scott JD (1997). "Regulation of the AKAP79-protein kinase C interaction by Ca2+/Calmodulin" . J. Biol. Chem . 272 (27): 17038–44. doi :10.1074/jbc.272.27.17038 . PMID 9202019 .
Kashishian A, Howard M, Loh C, et al. (1998). "AKAP79 inhibits calcineurin through a site distinct from the immunophilin-binding region" . J. Biol. Chem . 273 (42): 27412–9. doi :10.1074/jbc.273.42.27412 . PMID 9765270 .
Paolillo M, Feliciello A, Porcellini A, et al. (1999). "The type and the localization of cAMP-dependent protein kinase regulate transmission of cAMP signals to the nucleus in cortical and cerebellar granule cells" . J. Biol. Chem . 274 (10): 6546–52. doi :10.1074/jbc.274.10.6546 . PMID 10037748 .
Dodge KL, Carr DW, Sanborn BM (1999). "Protein kinase A anchoring to the myometrial plasma membrane is required for cyclic adenosine 3',5'-monophosphate regulation of phosphatidylinositide turnover" . Endocrinology . 140 (11): 5165–70. doi :10.1210/endo.140.11.7133 . PMID 10537145 .
Fraser ID, Cong M, Kim J, et al. (2000). "Assembly of an A kinase-anchoring protein-beta(2)-adrenergic receptor complex facilitates receptor phosphorylation and signaling" . Curr. Biol . 10 (7): 409–12. doi :10.1016/S0960-9822(00)00419-X . PMID 10753752 .
Sík A, Gulácsi A, Lai Y, et al. (2000). "Localization of the A kinase anchoring protein AKAP79 in the human hippocampus". Eur. J. Neurosci . 12 (4): 1155–64. doi :10.1046/j.1460-9568.2000.00002.x . PMID 10762347 . S2CID 40933732 .
Colledge M, Dean RA, Scott GK, et al. (2000). "Targeting of PKA to glutamate receptors through a MAGUK-AKAP complex" . Neuron . 27 (1): 107–19. doi :10.1016/S0896-6273(00)00013-1 . PMID 10939335 .
Indolfi C, Stabile E, Coppola C, et al. (2001). "Membrane-bound protein kinase A inhibits smooth muscle cell proliferation in vitro and in vivo by amplifying cAMP-protein kinase A signals" . Circ. Res . 88 (3): 319–24. doi :10.1161/01.res.88.3.319 . PMID 11179200 .
Dart C, Leyland ML (2001). "Targeting of an A kinase-anchoring protein, AKAP79, to an inwardly rectifying potassium channel, Kir2.1" . J. Biol. Chem . 276 (23): 20499–505. doi :10.1074/jbc.M101425200 . PMID 11287423 .
Xie G, Raufman JP (2001). "Association of protein kinase A with AKAP150 facilitates pepsinogen secretion from gastric chief cells" . Am. J. Physiol. Gastrointest. Liver Physiol . 281 (4): G1051–8. doi :10.1152/ajpgi.2001.281.4.G1051 . PMID 11557526 . S2CID 20939022 .