Luke Jackson may refer to:

Arts and entertainment[edit]

• Luke Jackson (singer), British singer
• Luke Jackson, the title character of Cool Hand Luke, portrayed by Paul Newman
• Luke Jackson, author of Freaks, Geeks, and Asperger Syndrome

Sports[edit]

• Luke Jackson (baseball), (born 1991), American baseball player
• Luke Jackson (basketball, born 1981), American basketball player in the 2000s
• Lucious Jackson (1941–2022), also known as Luke Jackson, American basketball player in the 1960s and 1970s
• Luke Jackson (boxer) (born 1985), Australian amateur boxer
• Luke Jackson (footballer) (born 2001), Australian rules footballer