Protein-coding gene in the species Homo sapiens
Homeobox protein Nkx-6.1 is a protein that in humans is encoded by the NKX6-1 gene .[5] [6]
Function [ edit ] In the pancreas , NKX6.1 is required for the development of beta cells and is a potent bifunctional transcription regulator that binds to AT-rich sequences within the promoter region of target genes.[6]
References [ edit ]
^ a b c GRCh38: Ensembl release 89: ENSG00000163623 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000035187 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Inoue H, Rudnick A, German MS, Veile R, Donis-Keller H, Permutt MA (March 1997). "Isolation, characterization, and chromosomal mapping of the human Nkx6.1 gene (NKX6A), a new pancreatic islet homeobox gene". Genomics . 40 (2): 367–70. doi :10.1006/geno.1996.4568 . PMID 9119408 . ^ a b "Entrez Gene: NK6 homeobox 1" .
Further reading [ edit ]
Schisler JC, Fueger PT, Babu DA, et al. (2008). "Stimulation of human and rat islet beta-cell proliferation with retention of function by the homeodomain transcription factor Nkx6.1" . Mol. Cell. Biol . 28 (10): 3465–76. doi :10.1128/MCB.01791-07 . PMC 2423154 PMID 18347054 . Hori Y, Gu X, Xie X, Kim SK (2005). "Differentiation of insulin-producing cells from human neural progenitor cells" . PLOS Med . 2 (4): e103. doi :10.1371/journal.pmed.0020103 PMC 1087208 PMID 15839736 . Jørgensen MC, Vestergírd Petersen H, Ericson J, et al. (1999). "Cloning and DNA-binding properties of the rat pancreatic beta-cell-specific factor Nkx6.1" . FEBS Lett . 461 (3): 287–94. doi :10.1016/S0014-5793(99)01436-2 PMID 10567713 . S2CID 1735843 . Iype T, Taylor DG, Ziesmann SM, et al. (2004). "The transcriptional repressor Nkx6.1 also functions as a deoxyribonucleic acid context-dependent transcriptional activator during pancreatic beta-cell differentiation: evidence for feedback activation of the nkx6.1 gene by Nkx6.1" . Mol. Endocrinol . 18 (6): 1363–75. doi :10.1210/me.2004-0006 PMID 15056733 . Yokoi N, Kanamori M, Horikawa Y, et al. (2006). "Association studies of variants in the genes involved in pancreatic beta-cell function in type 2 diabetes in Japanese subjects" . Diabetes . 55 (8): 2379–86. doi :10.2337/db05-1203 PMID 16873704 . Zhu S, Xia HH, Yang Y, et al. (2009). "Alterations of gastric homeoprotein expression in Helicobacter pylori infection, incisural antralisation, and intestinal metaplasia". Dig. Dis. Sci . 54 (5): 996–1002. doi :10.1007/s10620-008-0459-8 . PMID 18754095 . S2CID 25173708 .
This article incorporates text from the United States National Library of Medicine , which is in the public domain .
(1) Basic domains
(1.1) Basic leucine zipper (bZIP )(1.2) Basic helix-loop-helix (bHLH )
Group A Group B Group CPAS Group D Group E Group F
(1.3) bHLH-ZIP (1.4) NF-1 (1.5) RF-X (1.6) Basic helix-span-helix (bHSH)
(2) Zinc finger DNA-binding domains
(2.1) Nuclear receptor (Cys4 )
subfamily 1 subfamily 2 subfamily 3 subfamily 4 subfamily 5 subfamily 6 subfamily 0
(2.2) Other Cys4 (2.3) Cys2 His2 (2.4) Cys6 (2.5) Alternating composition (2.6) WRKY
(4) β-Scaffold factors with minor groove contacts
(0) Other transcription factors
