| Hairy RNA localisation element (HLE) | |
|---|---|
 Predicted secondary structure and sequence conservation of HLE | |
| Identifiers | |
| Symbol | HLE |
| Rfam | RF00437 |
| Other data | |
| RNA type | Cis-reg |
| Domain(s) | Eukaryota |
| SO | SO:0000233 |
| PDB structures | PDBe |
The hairy localisation element (HLE) is an RNA element found in the 3' UTR of the hairy gene. HLE contains two stem-loops. HLE is essential for the mediation of apical localisation and the two stem-loop structures act to allow the recognition of hairy mRNA by the localisation machinery.[1] HLE is found in Drosophila species.
References[edit]
- ^ Bullock SL, Zicha D, Ish-Horowicz D (May 2003). "The Drosophila hairy RNA localization signal modulates the kinetics of cytoplasmic mRNA transport". The EMBO Journal. 22 (10): 2484–2494. doi:10.1093/emboj/cdg230. PMC 155988. PMID 12743042.