Class I PI 3-kinases are a subgroup of the enzyme family, phosphoinositide 3-kinase that possess a common protein domain structure, substrate specificity, and method of activation. Class I PI 3-kinases are further divided into two subclasses, class IA PI 3-kinases and class IB PI 3-kinases.

Class IA PI 3-kinases[edit]

Class IA PI 3-kinases are activated by receptor tyrosine kinases (RTKs).

There are three catalytic subunits that are classified as class IA PI 3-kinases:^{[citation needed]}

• p110α
• p110β
• p110δ

There are currently five regulatory subunits that are known to associate with class IA PI 3-kinases catalytic subunits:^{[citation needed]}

• p85α and p85β
• p55α and p55γ
• p50α

Class IB PI 3-kinases[edit]

Class IB PI 3-kinases are activated by G-protein-coupled receptors (GPCRs).

The only known class IB PI 3-kinase catalytic subunit is p110γ.

There are two known regulatory subunits for p110γ:

• p101
• p84/ p87PIKAP.

See also[edit]

• Phosphoinositide 3-kinase#Class I
• Phosphoinositide 3-kinase inhibitor

References[edit]

• Stein RC (September 2001). "Prospects for phosphoinositide 3-kinase inhibition as a cancer treatment". Endocr. Relat. Cancer. 8 (3): 237–48. CiteSeerX 10.1.1.324.8135. doi:10.1677/erc.0.0080237. PMID 11566615. S2CID 568427. Archived from the original on 2008-05-21. Retrieved 2008-09-24.
• Foster FM, Traer CJ, Abraham SM, Fry MJ (August 2003). "The phosphoinositide (PI) 3-kinase family". J. Cell Sci. 116 (Pt 15): 3037–40. doi:10.1242/jcs.00609. PMID 12829733.
• Vanhaesebroeck B, Waterfield MD (November 1999). "Signaling by distinct classes of phosphoinositide 3-kinases" (PDF). Exp. Cell Res. 253 (1): 239–54. doi:10.1006/excr.1999.4701. PMID 10579926. Archived from the original (PDF) on January 2, 2006.