THC Science

Function: Amylase is an enzyme that is responsible for the breaking of the bonds in starches, polysaccharides, and complex carbohydrates to be turned into simple sugars that will be easier to absorb.

Clinical Significance: Amylase also has medical history in the use of Pancreatic Enzyme Replacement Therapy (PERT). One of the components is Sollpura (liprotamase), which help in the breakdown of saccharides into simple sugars.

Lysozyme[edit]

Function: An enzyme that is produced by animals that forms part of the innate immune system and is abundant in the secretions of saliva, human milk, tears, and mucus. It functions as an antimicrobial agent by splitting the peptidoglycan component of bacterial cell walls, which then leads to cell death.

Clinical Significance: Toxic levels of blood are caused by the excessive production of lysozyme's by cancer cells. Lysozyme's have also been associated with Bronchopulmonary dysplasia (BPD) in newborns and is a key factor in providing the immunology of infants during breast feeding.

Sucrase[edit]

Function: Sucrase is a stomachs related protein that mobilizes hydrolysis to convert sucrose into glucose and fructose.

Clinical Significance: Low amounts of Sucrose also known as Sucrose intolerance happens when sucrose isn't being discharged in the small digestive tract. A result of this is extra gas.

Lactase[edit]

Function: lactase is located in the small digestives system of people and other creatures such as mammals. Lactase is the bases of the total absorption of milk.

Clinical Significance: People who are lactose intolerant have medicine that can help with the digestion. When you are lactose intolerant you might experience gas, bloating, and pain along with other symptoms regarding your digestive system.

Category:EC 3.3 (act on ether bonds)[edit]

Category:EC 3.4 (act on peptide bonds - Peptidase)[edit]

Category:EC 3.4.11
- Alanine aminopeptidase
Category:EC 3.4.15
- Angiotensin converting enzyme
Category:EC 3.4.21
- Serine protease
- Chymotrypsin (EC 3.4.21.1)
- Trypsin (EC 3.4.21.4)
- Thrombin (EC 3.4.21.5)
- Factor X (EC 3.4.21.6)
- Plasmin (EC 3.4.21.7)
- Acrosin (EC 3.4.21.10)
- Factor VII (EC 3.4.21.21)
- Factor IX (EC 3.4.21.22)
- Prolyl oligopeptidase (EC 3.4.21.26)
- Factor XI (EC 3.4.21.27)
- Elastase (EC 3.4.21.37)
- Factor XII (EC 3.4.21.38)
- Proteinase K (EC 3.4.21.64)
- Tissue plasminogen activator (EC 3.4.21.68)
- Protein C (EC 3.4.21.69)
Category:EC 3.4.22
- Separase (EC 3.4.22.49)
Category:EC 3.4.23
- Pepsin (EC 3.4.23.1)
- Rennet (EC 3.4.23.4)
- Renin (EC 3.4.23.15)
- Trypsinogen (EC 3.4.23.18) and (20/21/23/24/26)
- Plasmepsin (EC 3.4.23.39)
Category:EC 3.4.24
- Matrix metalloproteinase (EC 3.4.24.7)
Category:EC 3.4.25
- Metalloendopeptidase

Category:EC 3.5 (act on carbon–nitrogen bonds, other than peptide bonds)[edit]

Category:EC 3.5.1 (In linear amides)
- Urease (EC 3.5.1.5)
Category:EC 3.5.2 (In cyclic amides)
- Beta-lactamase (EC 3.5.2.6)
Category:EC 3.5.3 (In linear amidines)
- Arginase (EC 3.5.3.1)
Category:EC 3.5.4 (In cyclic amidines)
- Adenosine deaminase (EC 3.5.4.4)
- GTP cyclohydrolase I (EC 3.5.4.16)
Category:EC 3.5.5 (In nitriles)
- Nitrilase (EC 3.5.5.1)

Category:EC 3.6 (act on acid anhydrides)[edit]

Category:EC 3.6.1
Category:EC 3.6.3
- ATPase
- NaKATPase (EC 3.6.3.9)
- ATP synthase (EC 3.6.3.14)

Category:EC 3.7 (act on carbon–carbon bonds)[edit]

Kynureninase EC 3.7.1.3

Category:EC 3.8 (act on halide bonds)[edit]

EC 3.8.1.3 Haloacetate dehalogenase

Category:EC 3.9 (act on phosphorus–nitrogen bonds)[edit]

EC 3.9.1.1: Phosphoamidase
EC 3.9.1.2: Protein arginine phosphatase
EC 3.9.1.3: Phosphohistidine phosphatase

Category:EC 3.10 (act on sulfur–nitrogen bonds)[edit]

Category:EC 3.11 (act on carbon–phosphorus bonds)[edit]

Category:EC 3.12 (act on sulfur–sulfur bonds)[edit]

EC 3.12.1.1: Trithionate hydrolase

Category:EC 3.13 (act on carbon–sulfur bonds)[edit]

EC 3.13.1.1: UDP-sulfoquinovose synthase
EC 3.13.1.3: 2'-hydroxybiphenyl-2-sulfinate desulfinase
EC 3.13.1.4: 3-sulfinopropanoyl—CoA desulfinase
EC 3.13.1.5: Carbon disulfide hydrolase
EC 3.13.1.6: (CysO sulfur-carrier protein)-S-L-cysteine hydrolase
EC 3.13.1.7: Carbonyl sulfide hydrolase
EC 3.13.1.8: S-adenosyl-L-methionine hydrolase (adenosine-forming)

Category:Lyases (EC 4) (Lyase)[edit]

Category:EC 4.1 (carbon–carbon lyases)[edit]

Category:EC 4.1.1
Category:EC 4.1.2
- Fructose-bisphosphate aldolase (EC 4.1.2.13)

Category:EC 4.2 (carbon–oxygen lyases)[edit]

Category:EC 4.2.1
- Carbonic anhydrase (EC 4.2.1.1)
- Tryptophan synthase (EC 4.2.1.20)

Category:EC 4.3 (carbon–nitrogen lyases)[edit]

Category:EC 4.3.1
- Phenylalanine ammonia-lyase (EC 4.3.1.24)

Category:EC 4.4 (carbon–sulfur lyases)[edit]

Category:EC 4.4.1

Category:EC 4.5 (carbon–halide lyases)[edit]

Category:EC 4.5.1
- Dichloromethane dehalogenase
- Halohydrin dehalogenase

Category:EC 4.6 (phosphorus–oxygen lyases)[edit]

Category:EC 4.6.1
- Adenylate cyclase (EC 4.6.1.1)
- Guanylate cyclase (EC 4.6.1.2)

Category:Isomerases (EC 5) (Isomerase)[edit]

Category:EC 5.1 (racemases and epimerases)[edit]

Category:EC 5.2 (cis-trans-isomerases)[edit]

Category:EC 5.3 (intramolecular oxidoreductases)[edit]

Category:EC 5.3.3
- Enoyl CoA isomerase (EC 5.3.3.8)
Category:EC 5.3.4
- Protein disulfide isomerase (EC 5.3.4.1)

Category:EC 5.4 (intramolecular transferases -- mutases)[edit]

Category:EC 5.4.2
- Phosphoglucomutase (EC 5.4.2.2)

Category:EC 5.5 (intramolecular lyases)[edit]

Intramolecular lyases:
EC number	Examples
EC 5.5.1.1	Muconate cycloisomerase
EC 5.5.1.2	3-carboxy-cis,cis-muconate cycloisomerase
EC 5.5.1.3	Tetrahydroxypteridine cycloisomerase
EC 5.5.1.4	Inositol-3-phosphate synthase
EC 5.5.1.5	Carboxy-cis,cis-muconate cyclase
EC 5.5.1.6	Chalcone isomerase
EC 5.5.1.7	Chloromuconate cycloisomerase
EC 5.5.1.8	(+)-bornyl diphosphate synthase
EC 5.5.1.9	Cycloeucalenol cycloisomerase
EC 5.5.1.10	Alpha-pinene-oxide decyclase
EC 5.5.1.11	Dichloromuconate cycloisomerase
EC 5.5.1.12	Copalyl diphosphate synthase
EC 5.5.1.13	Ent-copalyl diphosphate synthase
EC 5.5.1.14	Syn-copalyl-diphosphate synthase
EC 5.5.1.15	Terpentedienyl-diphosphate synthase
EC 5.5.1.16	Halimadienyl-diphosphate synthase
EC 5.5.1.17	(S)-beta-macrocarpene synthase
EC 5.5.1.18	Lycopene epsilon-cyclase
EC 5.5.1.19	Lycopene beta-cyclase
EC 5.5.1.20	Prosolanapyrone-III cycloisomerase
EC 5.5.1.n1	D-ribose pyranase
EC 5.5.1.22	Steroid Delta Isomerase

Category:EC 5.99 (other isomerases)[edit]

Category:EC 5.99.1
- Topoisomerase (type I: EC 5.99.1.2, type II: EC 5.99.1.3)

Category:Ligases (EC 6) (Ligase)[edit]

Category:EC 6.1 (form carbon–oxygen bonds)[edit]

6-carboxytetrahydropterin synthase

Category:EC 6.1.1
- FARSB (EC 6.1.1.20)

Category:EC 6.2 (form carbon–sulfur bonds)[edit]

EC 6.2.1.1: Acetate—CoA ligase
EC 6.2.1.2: Medium-chain acyl—CoA ligase
EC 6.2.1.3: Long-chain-fatty-acid—CoA ligase
EC 6.2.1.4: Succinate—CoA ligase (GDP-forming)
EC 6.2.1.5: Succinate—CoA ligase (ADP-forming)
EC 6.2.1.6: Glutarate—CoA ligase
EC 6.2.1.7: Cholate—CoA ligase
EC 6.2.1.8: Oxalate—CoA ligase
EC 6.2.1.9: Malate—CoA ligase
EC 6.2.1.10: Acid—CoA ligase (GDP-forming)
EC 6.2.1.11: Biotin—CoA ligase
EC 6.2.1.12: 4-coumarate—CoA ligase
EC 6.2.1.13: Acetate—CoA ligase (ADP-forming)
EC 6.2.1.14: 6-carboxyhexanoate—CoA ligase
EC 6.2.1.15: Arachidonate—CoA ligase
EC 6.2.1.16: Acetoacetate—CoA ligase
EC 6.2.1.17: Propionate—CoA ligase
EC 6.2.1.18: Citrate—CoA ligase
EC 6.2.1.19: Long-chain-fatty-acid-luciferin-component ligase
EC 6.2.1.20: Long-chain-fatty-acid-(acyl-carrier-protein) ligase
EC 6.2.1.21: Transferred entry: 6.2.1.30
EC 6.2.1.22: (citrate (pro-3S)-lyase) ligase
EC 6.2.1.23: Dicarboxylate—CoA ligase
EC 6.2.1.24: Phytanate—CoA ligase
EC 6.2.1.25: Benzoate—CoA ligase
EC 6.2.1.26: o-succinylbenzoate—CoA ligase
EC 6.2.1.27: 4-hydroxybenzoate—CoA ligase
EC 6.2.1.28: 3-alpha,7-alpha-dihydroxy-5-beta-cholestanate—CoA ligase
EC 6.2.1.29: Transferred entry: 6.2.1.7
EC 6.2.1.30: Phenylacetate—CoA ligase
EC 6.2.1.31: 2-furoate—CoA ligase
EC 6.2.1.32: Anthranilate—CoA ligase
EC 6.2.1.33: 4-chlorobenzoate—CoA ligase
EC 6.2.1.34: Trans-feruloyl-CoA synthase
EC 6.2.1.35: ACP-SH:acetate ligase
EC 6.2.1.36: 3-hydroxypropionyl-CoA synthase
EC 6.2.1.37: 3-hydroxybenzoate—CoA ligase
EC 6.2.1.38: (2,2,3-trimethyl-5-oxocyclopent-3-enyl)acetyl-CoA synthase
EC 6.2.1.39: (butirosin acyl-carrier protein)—L-glutamate ligase
EC 6.2.1.40: 4-hydroxybutyrate-CoA ligase
EC 6.2.1.41: 3-((3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl)propanoate-CoA ligase
EC 6.2.1.42: 3-oxocholest-4-en-26-oate-CoA ligase
EC 6.2.1.43: 2-hydroxy-7-methoxy-5-methyl-1-naphthoate-CoA ligase
EC 6.2.1.44: 3-(methylthio)propionyl-CoA ligase
EC 6.2.1.45: E1 ubiquitin-activating enzyme
EC 6.2.1.46: L-allo-isoleucine--holo-CmaA peptidyl-carrier protein ligase
EC 6.2.1.47: Medium-chain-fatty-acid-(acyl-carrier-protein) ligase
EC 6.2.1.48: Carnitine-CoA ligase
EC 6.2.1.49: Long-chain fatty acid adenylyltransferase FadD28
EC 6.2.1.50: 4-hydroxybenzoate adenylyltransferase FadD22
EC 6.2.1.51: 4-hydroxyphenylalkanoate adenylyltransferase FadD29
EC 6.2.1.52: L-firefly luciferin-CoA ligase
EC 6.2.1.53: L-proline-L-prolyl-carrier protein ligase
EC 6.2.1.54: D-alanine-D-alanyl-carrier protein ligase
EC 6.2.1.55: E1 SAMP-activating enzyme

Category:Oxidoreductases (EC 1) (Oxidoreductase)[edit]

Category:EC 1.1 (act on the CH-OH group of donors)[edit]

Category:EC 1.2 (act on the aldehyde or oxo group of donors)[edit]

Category:EC 1.3 (act on the CH-CH group of donors)[edit]

Category:EC 1.4 (act on the CH-NH2 group of donors)[edit]

Category:EC 1.5 (act on CH-NH group of donors)[edit]

Category:EC 1.6 (act on NADH or NADPH)[edit]

Category:EC 1.7 (act on other nitrogenous compounds as donors)[edit]

Category:EC 1.8 (act on a sulfur group of donors)[edit]

Category:EC 1.9 (act on a heme group of donors)[edit]

Category:EC 1.10 (act on diphenols and related substances as donors)[edit]

Category:EC 1.11 (act on peroxide as an acceptor -- peroxidases)[edit]

Category:EC 1.12 (act on hydrogen as a donor)[edit]

Category:EC 1.13 (act on single donors with incorporation of molecular oxygen)[edit]

Category:EC 1.14 (act on paired donors with incorporation of molecular oxygen)[edit]

Category:EC 1.15 (act on superoxide radicals as acceptors)[edit]

Category:EC 1.16 (oxidize metal ions)[edit]

Category:EC 1.17 (act on CH or CH2 groups)[edit]

Category:EC 1.18 (act on iron–sulfur proteins as donors)[edit]

Category:EC 1.19 (act on reduced flavodoxin as donor)[edit]

Category:EC 1.20 (act on phosphorus or arsenic as donors)[edit]

Category:EC 1.21 (act on X-H and Y-H to form an X-Y bond)[edit]

Category:EC 1.97 (other oxidoreductases)[edit]

Category:Transferases (EC 2) (Transferase)[edit]

Category:EC 2.1 (transfer one-carbon groups, Methylase)[edit]

Category:EC 2.2 (transfer aldehyde or ketone groups)[edit]

Category:EC 2.3 (acyltransferases)[edit]

Category:EC 2.4 (glycosyltransferases)[edit]

Category:EC 2.5 (transfer alkyl or aryl groups, other than methyl groups)[edit]

Category:EC 2.6 (transfer nitrogenous groups)[edit]

Category:EC 2.7 (transfer phosphorus-containing groups)[edit]

Category:EC 2.8 (transfer sulfur-containing groups)[edit]

Category:EC 2.9 (transfer selenium-containing groups)[edit]

Category:Hydrolases (EC 3) (Hydrolase)[edit]

Category:EC 3.1 (act on ester bonds)[edit]

Category:EC 3.2 (act on sugars - glycosylases)[edit]

Function and clinical importance of some enzymes in category 3.2.1[edit]

Amylase[edit]