Charles Cobb may refer to:

• Charles Cobb (cricketer) (1863–1922), English cricketer
• Charles Cobb (economist) (1875–1949), American mathematician and economist
• Charles E. Cobb (born 1936), American businessman
• Charles E. Cobb Jr. (born 1943), journalist, professor and former activist
• Charles Cobb (American football), American football player and coach
• Charley Cobb, American football coach
• Charlie Cobb, athletic director for Georgia State University

• Charles Cobbe (1686–1765), Primate of Ireland
• Cobb (surname)