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NUP54
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4JNU, 4JNV, 4JO7, 4JO9, 5IJO, 5IJN
Identifiers
Aliases	NUP54, nucleoporin 54
External IDs	OMIM: 607607 MGI: 1920460 HomoloGene: 41169 GeneCards: NUP54
Gene location (Human)
Chr.	Chromosome 4 (human)
End	76,148,485 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	92,583,078 bp
RNA expression pattern
	Top expressed in
	Top expressed in
	More reference expression data
	More reference expression data
Gene ontology
Molecular function
Cellular component
Biological process
	Sources:Amigo / QuickGO
Orthologs
	53371
	269113
	ENSG00000138750
	ENSMUSG00000034826
	Q7Z3B4
	Q8BTS4
	NM_001278603; NM_017426
	NM_183392; NM_001359995
	NP_001265532; NP_059122
	NP_899248; NP_001346924
	Wikidata
View/Edit Human	View/Edit Mouse

Nucleoporin 54 (Nup54) is a protein that in humans is encoded by the NUP54 gene.^[5]^[6]

Function[edit]

The nuclear envelope creates distinct nuclear and cytoplasmic compartments in eukaryotic cells. It consists of two concentric membranes perforated by nuclear pores, large protein complexes that form aqueous channels to regulate the flow of macromolecules between the nucleus and the cytoplasm. These complexes are composed of at least 100 different polypeptide subunits, many of which belong to the nucleoporin family. This gene encodes a member of the phe-gly (FG) repeat-containing nucleoporin subset.^[6]

References[edit]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000138750 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000034826 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Hu T, Guan T, Gerace L (Sep 1996). "Molecular and functional characterization of the p62 complex, an assembly of nuclear pore complex glycoproteins". J Cell Biol. 134 (3): 589–601. doi:10.1083/jcb.134.3.589. PMC 2120945. PMID 8707840.
^ ^a ^b "Entrez Gene: NUP54 nucleoporin 54kDa".

Further reading[edit]

Stoffler D, Fahrenkrog B, Aebi U (1999). "The nuclear pore complex: from molecular architecture to functional dynamics". Curr. Opin. Cell Biol. 11 (3): 391–401. doi:10.1016/S0955-0674(99)80055-6. PMID 10395558.
Bodoor K, Shaikh S, Enarson P, Chowdhury S, Salina D, Raharjo WH, Burke B (1999). "Function and assembly of nuclear pore complex proteins". Biochem. Cell Biol. 77 (4): 321–329. doi:10.1139/bcb-77-4-321. PMID 10546895.
Finlay DR, Meier E, Bradley P, Horecka J, Forbes DJ (1991). "A complex of nuclear pore proteins required for pore function". J. Cell Biol. 114 (1): 169–183. doi:10.1083/jcb.114.1.169. PMC 2289063. PMID 2050741.
Buss F, Stewart M (1995). "Macromolecular interactions in the nucleoporin p62 complex of rat nuclear pores: binding of nucleoporin p54 to the rod domain of p62". J. Cell Biol. 128 (3): 251–261. doi:10.1083/jcb.128.3.251. PMC 2120351. PMID 7531196.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–174. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Guan T, Müller S, Klier G, Panté N, Blevitt JM, Haner M, Paschal B, Aebi U, Gerace L (1996). "Structural analysis of the p62 complex, an assembly of O-linked glycoproteins that localizes near the central gated channel of the nuclear pore complex". Mol. Biol. Cell. 6 (11): 1591–1603. doi:10.1091/mbc.6.11.1591. PMC 301313. PMID 8589458.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–156. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Popov S, Rexach M, Ratner L, Blobel G, Bukrinsky M (1998). "Viral protein R regulates docking of the HIV-1 preintegration complex to the nuclear pore complex". J. Biol. Chem. 273 (21): 13347–13352. doi:10.1074/jbc.273.21.13347. PMID 9582382.
Hu RM, Han ZG, Song HD, Peng YD, Huang QH, Ren SX, Gu YJ, Huang CH, Li YB, Jiang CL, Fu G, Zhang QH, Gu BW, Dai M, Mao YF, Gao GF, Rong R, Ye M, Zhou J, Xu SH, Gu J, Shi JX, Jin WR, Zhang CK, Wu TM, Huang GY, Chen Z, Chen MD, Chen JL (2000). "Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning". Proc. Natl. Acad. Sci. U.S.A. 97 (17): 9543–9548. Bibcode:2000PNAS...97.9543H. doi:10.1073/pnas.160270997. PMC 16901. PMID 10931946.

External links[edit]

PDBe-KB provides an overview of all the structure information available in the PDB for Human Nucleoporin p54

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000138750 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000034826 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8707840-5] Hu T, Guan T, Gerace L (Sep 1996). "Molecular and functional characterization of the p62 complex, an assembly of nuclear pore complex glycoproteins". J Cell Biol. 134 (3): 589–601. doi:10.1083/jcb.134.3.589. PMC 2120945. PMID 8707840.

[entrez-6] "Entrez Gene: NUP54 nucleoporin 54kDa".

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Autoantigens
Dehydrogenase	Branched-chain alpha-keto acid dehydrogenase complex Oxoglutarate dehydrogenase Pyruvate dehydrogenase
Transglutaminase	Epidermal transglutaminase Tissue transglutaminase
Nucleoporins	NUP35 NUP37 NUP43 NUP50 NUP54 NUP62 NUP85 NUP88 NUP93 NUP98 NUP107 NUP133 NUP153 NUP155 NUP160 NUP188 NUP210 NUP205 NUP214
Other	Acetylcholine receptor Actin Apolipoprotein H Cardiolipin Centromere Filaggrin (Citrullinate) Gangliosides Sp100 nuclear antigen Thrombin Topoisomerase

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