Protein-coding gene in the species Homo sapiens
Myocyte-specific enhancer factor 2D is a protein that in humans is encoded by the MEF2D gene .[5] [6]
Interactions [ edit ] MEF2D has been shown to interact with:
See also [ edit ] References [ edit ]
^ a b c GRCh38: Ensembl release 89: ENSG00000116604 - Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000001419 - Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Breitbart RE, Liang CS, Smoot LB, Laheru DA, Mahdavi V, Nadal-Ginard B (Aug 1993). "A fourth human MEF2 transcription factor, hMEF2D, is an early marker of the myogenic lineage". Development . 118 (4): 1095–1106. doi :10.1242/dev.118.4.1095 . PMID 8269842 . ^ "Entrez Gene: MEF2D MADS box transcription enhancer factor 2, polypeptide D (myocyte enhancer factor 2D)" .^ a b Youn HD, Liu JO (Jul 2000). "Cabin1 represses MEF2-dependent Nur77 expression and T cell apoptosis by controlling association of histone deacetylases and acetylases with MEF2" . Immunity . 13 (1): 85–94. doi :10.1016/s1074-7613(00)00010-8 PMID 10933397 . ^ Youn HD, Sun L, Prywes R, Liu JO (Oct 1999). "Apoptosis of T cells mediated by Ca2+-induced release of the transcription factor MEF2". Science . 286 (5440): 790–793. doi :10.1126/science.286.5440.790 . PMID 10531067 . ^ Youn HD, Grozinger CM, Liu JO (Jul 2000). "Calcium regulates transcriptional repression of myocyte enhancer factor 2 by histone deacetylase 4" . The Journal of Biological Chemistry . 275 (29): 22563–22567. doi :10.1074/jbc.C000304200 PMID 10825153 . ^ Yang CC, Ornatsky OI, McDermott JC, Cruz TF, Prody CA (Oct 1998). "Interaction of myocyte enhancer factor 2 (MEF2) with a mitogen-activated protein kinase, ERK5/BMK1" . Nucleic Acids Research . 26 (20): 4771–4777. doi :10.1093/nar/26.20.4771 . PMC 147902 PMID 9753748 . ^ Ornatsky OI, McDermott JC (Oct 1996). "MEF2 protein expression, DNA binding specificity and complex composition, and transcriptional activity in muscle and non-muscle cells" . The Journal of Biological Chemistry . 271 (40): 24927–24933. doi :10.1074/jbc.271.40.24927 PMID 8798771 . ^ Youn HD, Chatila TA, Liu JO (Aug 2000). "Integration of calcineurin and MEF2 signals by the coactivator p300 during T-cell apoptosis" . The EMBO Journal . 19 (16): 4323–4331. doi :10.1093/emboj/19.16.4323 . PMC 302027 PMID 10944115 . ^ Park SY, Shin HM, Han TH (Sep 2002). "Synergistic interaction of MEF2D and Sp1 in activation of the CD14 promoter". Molecular Immunology . 39 (1–2): 25–30. doi :10.1016/s0161-5890(02)00055-x . PMID 12213324 . ^ Choi SJ, Park SY, Han TH (Jul 2001). "14-3-3tau associates with and activates the MEF2D transcription factor during muscle cell differentiation" . Nucleic Acids Research . 29 (13): 2836–2842. doi :10.1093/nar/29.13.2836 . PMC 55772 PMID 11433030 .
Further reading [ edit ]
Hobson GM, Krahe R, Garcia E, Siciliano MJ, Funanage VL (Oct 1995). "Regional chromosomal assignments for four members of the MADS domain transcription enhancer factor 2 (MEF2) gene family to human chromosomes 15q26, 19p12, 5q14, and 1q12-q23". Genomics . 29 (3): 704–711. doi :10.1006/geno.1995.9007 . PMID 8575763 . Ornatsky OI, McDermott JC (Oct 1996). "MEF2 protein expression, DNA binding specificity and complex composition, and transcriptional activity in muscle and non-muscle cells" . The Journal of Biological Chemistry . 271 (40): 24927–24933. doi :10.1074/jbc.271.40.24927 PMID 8798771 . Yang CC, Ornatsky OI, McDermott JC, Cruz TF, Prody CA (Oct 1998). "Interaction of myocyte enhancer factor 2 (MEF2) with a mitogen-activated protein kinase, ERK5/BMK1" . Nucleic Acids Research . 26 (20): 4771–4777. doi :10.1093/nar/26.20.4771 . PMC 147902 PMID 9753748 . Zhao M, New L, Kravchenko VV, Kato Y, Gram H, di Padova F, Olson EN, Ulevitch RJ, Han J (Jan 1999). "Regulation of the MEF2 family of transcription factors by p38" . Molecular and Cellular Biology . 19 (1): 21–30. doi :10.1128/mcb.19.1.21 . PMC 83862 PMID 9858528 . Wang AH, Bertos NR, Vezmar M, Pelletier N, Crosato M, Heng HH, Th'ng J, Han J, Yang XJ (Nov 1999). "HDAC4, a human histone deacetylase related to yeast HDA1, is a transcriptional corepressor" . Molecular and Cellular Biology . 19 (11): 7816–7827. doi :10.1128/mcb.19.11.7816 . PMC 84849 PMID 10523670 . Lu J, McKinsey TA, Nicol RL, Olson EN (Apr 2000). "Signal-dependent activation of the MEF2 transcription factor by dissociation from histone deacetylases" . Proceedings of the National Academy of Sciences of the United States of America . 97 (8): 4070–4075. Bibcode :2000PNAS...97.4070L . doi :10.1073/pnas.080064097 PMC 18151 PMID 10737771 . Kato Y, Zhao M, Morikawa A, Sugiyama T, Chakravortty D, Koide N, Yoshida T, Tapping RI, Yang Y, Yokochi T, Lee JD (Jun 2000). "Big mitogen-activated kinase regulates multiple members of the MEF2 protein family" . The Journal of Biological Chemistry . 275 (24): 18534–18540. doi :10.1074/jbc.M001573200 PMID 10849446 . Youn HD, Chatila TA, Liu JO (Aug 2000). "Integration of calcineurin and MEF2 signals by the coactivator p300 during T-cell apoptosis" . The EMBO Journal . 19 (16): 4323–4331. doi :10.1093/emboj/19.16.4323 . PMC 302027 PMID 10944115 . Slepak TI, Webster KA, Zang J, Prentice H, O'Dowd A, Hicks MN, Bishopric NH (Mar 2001). "Control of cardiac-specific transcription by p300 through myocyte enhancer factor-2D" . The Journal of Biological Chemistry . 276 (10): 7575–7585. doi :10.1074/jbc.M004625200 PMID 11096067 . Choi SJ, Park SY, Han TH (Jul 2001). "14-3-3tau associates with and activates the MEF2D transcription factor during muscle cell differentiation" . Nucleic Acids Research . 29 (13): 2836–2842. doi :10.1093/nar/29.13.2836 . PMC 55772 PMID 11433030 . Okamoto S, Li Z, Ju C, Scholzke MN, Mathews E, Cui J, Salvesen GS, Bossy-Wetzel E, Lipton SA (Mar 2002). "Dominant-interfering forms of MEF2 generated by caspase cleavage contribute to NMDA-induced neuronal apoptosis" . Proceedings of the National Academy of Sciences of the United States of America . 99 (6): 3974–3979. Bibcode :2002PNAS...99.3974O . doi :10.1073/pnas.022036399 PMC 122633 PMID 11904443 . Park SY, Shin HM, Han TH (Sep 2002). "Synergistic interaction of MEF2D and Sp1 in activation of the CD14 promoter". Molecular Immunology . 39 (1–2): 25–30. doi :10.1016/S0161-5890(02)00055-X . PMID 12213324 . Linseman DA, Bartley CM, Le SS, Laessig TA, Bouchard RJ, Meintzer MK, Li M, Heidenreich KA (Oct 2003). "Inactivation of the myocyte enhancer factor-2 repressor histone deacetylase-5 by endogenous Ca(2+) //calmodulin-dependent kinase II promotes depolarization-mediated cerebellar granule neuron survival" . The Journal of Biological Chemistry . 278 (42): 41472–41481. doi :10.1074/jbc.M307245200 PMID 12896970 . Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (Aug 2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins" . Proceedings of the National Academy of Sciences of the United States of America . 101 (33): 12130–12135. Bibcode :2004PNAS..10112130B . doi :10.1073/pnas.0404720101 PMC 514446 PMID 15302935 . Grégoire S, Yang XJ (Mar 2005). "Association with class IIa histone deacetylases upregulates the sumoylation of MEF2 transcription factors" . Molecular and Cellular Biology . 25 (6): 2273–2287. doi :10.1128/MCB.25.6.2273-2287.2005 . PMC 1061617 PMID 15743823 . Prima V, Gore L, Caires A, Boomer T, Yoshinari M, Imaizumi M, Varella-Garcia M, Hunger SP (May 2005). "Cloning and functional characterization of MEF2D/DAZAP1 and DAZAP1/MEF2D fusion proteins created by a variant t(1;19)(q23;p13.3) in acute lymphoblastic leukemia" . Leukemia . 19 (5): 806–813. doi :10.1038/sj.leu.2403684 PMID 15744350 .
External links [ edit ]
(1) Basic domains
(1.1) Basic leucine zipper (bZIP )(1.2) Basic helix-loop-helix (bHLH )
Group A Group B Group CPAS Group D Group E Group F
(1.3) bHLH-ZIP (1.4) NF-1 (1.5) RF-X (1.6) Basic helix-span-helix (bHSH)
(2) Zinc finger DNA-binding domains
(2.1) Nuclear receptor (Cys4 )
subfamily 1 subfamily 2 subfamily 3 subfamily 4 subfamily 5 subfamily 6 subfamily 0
(2.2) Other Cys4 (2.3) Cys2 His2 (2.4) Cys6 (2.5) Alternating composition (2.6) WRKY
(4) β-Scaffold factors with minor groove contacts
(0) Other transcription factors
