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FZD6
Identifiers
Aliases	FZD6, FZ-6, FZ6, HFZ6, NDNC10, frizzled class receptor 6, NDNC1
External IDs	OMIM: 603409 MGI: 108474 HomoloGene: 2617 GeneCards: FZD6
Gene location (Human)
Chr.	Chromosome 8 (human)
End	103,332,866 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	38,901,583 bp
RNA expression pattern
	Top expressed in
	Top expressed in
	More reference expression data
	More reference expression data
Gene ontology
Molecular function
Cellular component
Biological process
	Sources:Amigo / QuickGO
Orthologs
	8323
	14368
	ENSG00000164930
	ENSMUSG00000022297
	O60353
	Q61089
	NM_001164615; NM_001164616; NM_003506; NM_001317796
	NM_001162494; NM_008056
NP_001158087; NP_001158088; NP_001304725; NP_003497; NP_001158087.1;
	NP_003497.2
	NP_001155966; NP_032082
	Wikidata
View/Edit Human	View/Edit Mouse

Frizzled-6 (Fz-6) is a protein that in humans is encoded by the FZD6 gene.^[5]^[6]^[7]

Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for WNT signaling proteins. The FZD6 protein contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, and 7 transmembrane domains. However, unlike many other FZD family members, FDZ6 does not contain a C-terminal PDZ domain-binding motif.^[7] Fz-6 is believed to be the receptor for the WNT4 ligand.^[8]

Interactions[edit]

Fz-6 has been shown to interact with secreted frizzled-related protein 1.^[9]

References[edit]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000164930 - Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000022297 - Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Tokuhara M, Hirai M, Atomi Y, Terada M, Katoh M (Feb 1998). "Molecular cloning of human Frizzled-6". Biochemical and Biophysical Research Communications. 243 (2): 622–7. doi:10.1006/bbrc.1998.8143. PMID 9480858.
^ Golan T, Yaniv A, Bafico A, Liu G, Gazit A (Apr 2004). "The human Frizzled 6 (HFz6) acts as a negative regulator of the canonical Wnt. beta-catenin signaling cascade". The Journal of Biological Chemistry. 279 (15): 14879–88. doi:10.1074/jbc.M306421200. PMID 14747478.
^ ^a ^b "Entrez Gene: FZD6 frizzled homolog 6 (Drosophila)".
^ Lyons JP, Mueller UW, Ji H, Everett C, Fang X, Hsieh JC, Barth AM, McCrea PD (Aug 2004). "Wnt-4 activates the canonical beta-catenin-mediated Wnt pathway and binds Frizzled-6 CRD: functional implications of Wnt/beta-catenin activity in kidney epithelial cells". Experimental Cell Research. 298 (2): 369–87. doi:10.1016/j.yexcr.2004.04.036. PMID 15265686.
^ Bafico A, Gazit A, Pramila T, Finch PW, Yaniv A, Aaronson SA (Jun 1999). "Interaction of frizzled related protein (FRP) with Wnt ligands and the frizzled receptor suggests alternative mechanisms for FRP inhibition of Wnt signaling". The Journal of Biological Chemistry. 274 (23): 16180–7. doi:10.1074/jbc.274.23.16180. PMID 10347172.

External links[edit]

"Frizzled Receptors: FZD₆". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Archived from the original on 2016-01-24. Retrieved 2008-12-04.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000164930 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000022297 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9480858-5] Tokuhara M, Hirai M, Atomi Y, Terada M, Katoh M (Feb 1998). "Molecular cloning of human Frizzled-6". Biochemical and Biophysical Research Communications. 243 (2): 622–7. doi:10.1006/bbrc.1998.8143. PMID 9480858.

[pmid14747478-6] Golan T, Yaniv A, Bafico A, Liu G, Gazit A (Apr 2004). "The human Frizzled 6 (HFz6) acts as a negative regulator of the canonical Wnt. beta-catenin signaling cascade". The Journal of Biological Chemistry. 279 (15): 14879–88. doi:10.1074/jbc.M306421200. PMID 14747478.

[entrez-7] "Entrez Gene: FZD6 frizzled homolog 6 (Drosophila)".

[pmid15265686-8] Lyons JP, Mueller UW, Ji H, Everett C, Fang X, Hsieh JC, Barth AM, McCrea PD (Aug 2004). "Wnt-4 activates the canonical beta-catenin-mediated Wnt pathway and binds Frizzled-6 CRD: functional implications of Wnt/beta-catenin activity in kidney epithelial cells". Experimental Cell Research. 298 (2): 369–87. doi:10.1016/j.yexcr.2004.04.036. PMID 15265686.

[pmid10347172-9] Bafico A, Gazit A, Pramila T, Finch PW, Yaniv A, Aaronson SA (Jun 1999). "Interaction of frizzled related protein (FRP) with Wnt ligands and the frizzled receptor suggests alternative mechanisms for FRP inhibition of Wnt signaling". The Journal of Biological Chemistry. 274 (23): 16180–7. doi:10.1074/jbc.274.23.16180. PMID 10347172.

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