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FHL3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1WYH, 2CUQ, 2EHE
Identifiers
Aliases	FHL3, SLIM2, four and a half LIM domains 3
External IDs	OMIM: 602790 MGI: 1341092 HomoloGene: 37928 GeneCards: FHL3
Gene location (Human)
Chr.	Chromosome 1 (human)
End	38,005,606 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	124,602,404 bp
RNA expression pattern
	Top expressed in
	Top expressed in
	More reference expression data
	More reference expression data
Gene ontology
Molecular function
Cellular component
Biological process
	Sources:Amigo / QuickGO
Orthologs
	2275
	14201
	ENSG00000183386
	ENSMUSG00000032643
	Q13643; Q96C98
	Q9R059
	NM_004468; NM_001243878
	NM_010213
	NP_001230807; NP_004459; NP_001230807.1
	NP_034343
	Wikidata
View/Edit Human	View/Edit Mouse

Four and a half LIM domains protein 3 is a protein that in humans is encoded by the FHL3 gene.^[5]^[6]^[7]

LIM proteins are defined by the possession of a highly conserved double zinc finger motif called the LIM domain.^[7]

Function[edit]

FHL3 plays a role in myogenesis,^[8] and also stimulates the development of neural crest by enhancing BMP signaling.^[9]

Interactions[edit]

FHL3 has been shown to interact with:

References[edit]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000183386 - Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000032643 - Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Morgan MJ, Madgwick AJ (October 1996). "Slim defines a novel family of LIM-proteins expressed in skeletal muscle". Biochem Biophys Res Commun. 225 (2): 632–8. doi:10.1006/bbrc.1996.1222. PMID 8753811.
^ Lee SM, Tsui SK, Chan KK, Kotaka M, Li HY, Chim SS, Waye MM, Fung KP, Lee CY (May 1999). "Chromosomal mapping of a skeletal muscle specific LIM-only protein FHL3 to the distal end of the short arm of human chromosome 1". Somat Cell Mol Genet. 24 (3): 197–202. doi:10.1023/B:SCAM.0000007122.03392.4b. PMID 10226657. S2CID 40511123.
^ ^a ^b "Entrez Gene: FHL3 four and a half LIM domains 3".
^ Cottle et al., J Cell Sci. 2007 Apr 15;120(Pt 8):1423-35. doi: 10.1242/jcs.004739
^ Intracellular enhancement of BMP signaling by LIM-domain protein FHL3 controls spatiotemporal emergence of the neural crest driven by WNT signaling Mansour Alkobtawi, Patrick Pla, Anne H. Monsoro-Burq bioRxiv 711192; doi: https://doi.org/10.1101/711192
^ ^a ^b Fimia GM, De Cesare D, Sassone-Corsi P (November 2000). "A family of LIM-only transcriptional coactivators: tissue-specific expression and selective activation of CREB and CREM". Mol. Cell. Biol. 20 (22): 8613–22. doi:10.1128/mcb.20.22.8613-8622.2000. PMC 102166. PMID 11046156.
^ ^a ^b Turner J, Nicholas H, Bishop D, Matthews JM, Crossley M (April 2003). "The LIM protein FHL3 binds basic Krüppel-like factor/Krüppel-like factor 3 and its co-repressor C-terminal-binding protein 2". J. Biol. Chem. 278 (15): 12786–95. doi:10.1074/jbc.M300587200. PMID 12556451.
^ Li HY, Ng EK, Lee SM, Kotaka M, Tsui SK, Lee CY, Fung KP, Waye MM (2001). "Protein–protein interaction of FHL3 with FHL2 and visualization of their interaction by green fluorescent proteins (GFP) two-fusion fluorescence resonance energy transfer (FRET)". J. Cell. Biochem. 80 (3): 293–303. doi:10.1002/1097-4644(20010301)80:3<293::AID-JCB10>3.0.CO;2-U. PMID 11135358. S2CID 36346381.
^ Samson T, Smyth N, Janetzky S, Wendler O, Müller JM, Schüle R, von der Mark H, von der Mark K, Wixler V (July 2004). "The LIM-only proteins FHL2 and FHL3 interact with alpha- and beta-subunits of the muscle alpha7beta1 integrin receptor". J. Biol. Chem. 279 (27): 28641–52. doi:10.1074/jbc.M312894200. PMID 15117962.

External links[edit]

FHL3+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000183386 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000032643 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8753811-5] Morgan MJ, Madgwick AJ (October 1996). "Slim defines a novel family of LIM-proteins expressed in skeletal muscle". Biochem Biophys Res Commun. 225 (2): 632–8. doi:10.1006/bbrc.1996.1222. PMID 8753811.

[pmid10226657-6] Lee SM, Tsui SK, Chan KK, Kotaka M, Li HY, Chim SS, Waye MM, Fung KP, Lee CY (May 1999). "Chromosomal mapping of a skeletal muscle specific LIM-only protein FHL3 to the distal end of the short arm of human chromosome 1". Somat Cell Mol Genet. 24 (3): 197–202. doi:10.1023/B:SCAM.0000007122.03392.4b. PMID 10226657. S2CID 40511123.

[entrez-7] "Entrez Gene: FHL3 four and a half LIM domains 3".

[8] Cottle et al., J Cell Sci. 2007 Apr 15;120(Pt 8):1423-35. doi: 10.1242/jcs.004739

[9] Intracellular enhancement of BMP signaling by LIM-domain protein FHL3 controls spatiotemporal emergence of the neural crest driven by WNT signaling Mansour Alkobtawi, Patrick Pla, Anne H. Monsoro-Burq bioRxiv 711192; doi: https://doi.org/10.1101/711192

[pmid11046156-10] Fimia GM, De Cesare D, Sassone-Corsi P (November 2000). "A family of LIM-only transcriptional coactivators: tissue-specific expression and selective activation of CREB and CREM". Mol. Cell. Biol. 20 (22): 8613–22. doi:10.1128/mcb.20.22.8613-8622.2000. PMC 102166. PMID 11046156.

[pmid12556451-11] Turner J, Nicholas H, Bishop D, Matthews JM, Crossley M (April 2003). "The LIM protein FHL3 binds basic Krüppel-like factor/Krüppel-like factor 3 and its co-repressor C-terminal-binding protein 2". J. Biol. Chem. 278 (15): 12786–95. doi:10.1074/jbc.M300587200. PMID 12556451.

[pmid11135358-12] Li HY, Ng EK, Lee SM, Kotaka M, Tsui SK, Lee CY, Fung KP, Waye MM (2001). "Protein–protein interaction of FHL3 with FHL2 and visualization of their interaction by green fluorescent proteins (GFP) two-fusion fluorescence resonance energy transfer (FRET)". J. Cell. Biochem. 80 (3): 293–303. doi:10.1002/1097-4644(20010301)80:3<293::AID-JCB10>3.0.CO;2-U. PMID 11135358. S2CID 36346381.

[pmid15117962-13] Samson T, Smyth N, Janetzky S, Wendler O, Müller JM, Schüle R, von der Mark H, von der Mark K, Wixler V (July 2004). "The LIM-only proteins FHL2 and FHL3 interact with alpha- and beta-subunits of the muscle alpha7beta1 integrin receptor". J. Biol. Chem. 279 (27): 28641–52. doi:10.1074/jbc.M312894200. PMID 15117962.

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Function[edit]

Interactions[edit]

References[edit]

Further reading[edit]

External links[edit]

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