Protein found in humans
NR2F1 Identifiers Aliases NR2F1 External IDs OMIM : 132890 MGI : 1352451 HomoloGene : 21158 GeneCards : NR2F1 Wikidata
COUP-TF1 (COUP T ranscription F actor 1 ) also known as NR2F1 (N uclear R eceptor subfamily 2 , group F , member 1 ) is a protein that in humans is encoded by the NR2F1 gene .[5] [6] nuclear hormone receptor family of steroid hormone receptors .
Function [ edit ] Coup (chicken ovalbumin upstream promoter) transcription factor binds to the ovalbumin promoter and, in conjunction with another protein (S300-II ) stimulates initiation of transcription .[7] [8] palindromes of the 5'-AGGTCA-3' motif.[9]
Interactions [ edit ] COUP-TFI has been shown to interact with:
Clinical [ edit ] Mutations in this gene have been associated with Bosch-Boonstra-Schaaf optic atrophy syndrome .[13]
References [ edit ]
^ a b c GRCh38: Ensembl release 89: ENSG00000175745 - Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000069171 - Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Entrez Gene: NR2F1 nuclear receptor subfamily 2, group F, member 1" .^ Qiu Y, Krishnan V, Zeng Z, Gilbert DJ, Copeland NG, Gibson L, Yang-Feng T, Jenkins NA, Tsai MJ, Tsai SY (Sep 1995). "Isolation, characterization, and chromosomal localization of mouse and human COUP-TF I and II genes" . Genomics . 29 (1): 240–6. doi :10.1006/geno.1995.1237 PMID 8530078 . ^ Sagami I, Tsai SY, Wang H, Tsai MJ, O'Malley BW (Dec 1986). "Identification of two factors required for transcription of the ovalbumin gene" . Molecular and Cellular Biology . 6 (12): 4259–67. doi :10.1128/MCB.6.12.4259 . PMC 367207 PMID 3796602 . ^ Tsai SY, Sagami I, Wang H, Tsai MJ, O'Malley BW (Aug 1987). "Interactions between a DNA-binding transcription factor (COUP) and a non-DNA binding factor (S300-II)". Cell . 50 (5): 701–9. doi :10.1016/0092-8674(87)90328-X . PMID 3040258 . S2CID 25136877 . ^ Tsai SY, Tsai MJ (Apr 1997). "Chick ovalbumin upstream promoter-transcription factors (COUP-TFs): coming of age" . Endocrine Reviews . 18 (2): 229–40. doi :10.1210/edrv.18.2.0294 PMID 9101138 . ^ a b Avram D, Fields A, Pretty On Top K, Nevrivy DJ, Ishmael JE, Leid M (Apr 2000). "Isolation of a novel family of C(2)H(2) zinc finger proteins implicated in transcriptional repression mediated by chicken ovalbumin upstream promoter transcription factor (COUP-TF) orphan nuclear receptors" . The Journal of Biological Chemistry . 275 (14): 10315–22. doi :10.1074/jbc.275.14.10315 PMC 2819356 PMID 10744719 . ^ Dressel U, Thormeyer D, Altincicek B, Paululat A, Eggert M, Schneider S, Tenbaum SP, Renkawitz R, Baniahmad A (May 1999). "Alien, a highly conserved protein with characteristics of a corepressor for members of the nuclear hormone receptor superfamily" . Molecular and Cellular Biology . 19 (5): 3383–94. doi :10.1128/mcb.19.5.3383 . PMC 84131 PMID 10207062 . ^ Métivier R, Gay FA, Hübner MR, Flouriot G, Salbert G, Gannon F, Kah O, Pakdel F (Jul 2002). "Formation of an hER alpha-COUP-TFI complex enhances hER alpha AF-1 through Ser118 phosphorylation by MAPK" . The EMBO Journal . 21 (13): 3443–53. doi :10.1093/emboj/cdf344 . PMC 126093 PMID 12093745 . ^ Hobbs MM, Wolters WC, Rayapati AO (2020) Bosch-Boonstra-Schaaf optic atrophy syndrome presenting as new-onset psychosis in a 32-year-old man: A case report and literature review. J Psychiatr Pract 26(1):58-62
External links [ edit ] Further reading [ edit ]
Kliewer SA, Umesono K, Heyman RA, Mangelsdorf DJ, Dyck JA, Evans RM (Feb 1992). "Retinoid X receptor-COUP-TF interactions modulate retinoic acid signaling" . Proceedings of the National Academy of Sciences of the United States of America . 89 (4): 1448–52. Bibcode :1992PNAS...89.1448K . doi :10.1073/pnas.89.4.1448 PMC 48468 PMID 1311101 . Berrodin TJ, Marks MS, Ozato K, Linney E, Lazar MA (Sep 1992). "Heterodimerization among thyroid hormone receptor, retinoic acid receptor, retinoid X receptor, chicken ovalbumin upstream promoter transcription factor, and an endogenous liver protein" . Molecular Endocrinology . 6 (9): 1468–78. doi :10.1210/mend.6.9.1331778 PMID 1331778 . S2CID 24291055 . Ing NH, Beekman JM, Tsai SY, Tsai MJ, O'Malley BW (Sep 1992). "Members of the steroid hormone receptor superfamily interact with TFIIB (S300-II)" . The Journal of Biological Chemistry . 267 (25): 17617–23. doi :10.1016/S0021-9258(19)37087-5 PMID 1517211 . Wang LH, Tsai SY, Cook RG, Beattie WG, Tsai MJ, O'Malley BW (Jul 1989). "COUP transcription factor is a member of the steroid receptor superfamily". Nature . 340 (6229): 163–6. Bibcode :1989Natur.340..163W . doi :10.1038/340163a0 . PMID 2739739 . S2CID 4364164 . Miyajima N, Kadowaki Y, Fukushige S, Shimizu S, Semba K, Yamanashi Y, Matsubara K, Toyoshima K, Yamamoto T (Dec 1988). "Identification of two novel members of erbA superfamily by molecular cloning: the gene products of the two are highly related to each other" . Nucleic Acids Research . 16 (23): 11057–74. doi :10.1093/nar/16.23.11057 . PMC 338996 PMID 2905047 . Sawaya BE, Rohr O, Aunis D, Schaeffer E (Sep 1996). "Chicken ovalbumin upstream promoter transcription factor, a transcriptional activator of HIV-1 gene expression in human brain cells" . The Journal of Biological Chemistry . 271 (38): 23572–6. doi :10.1074/jbc.271.38.23572 PMID 8798567 . Rohr O, Aunis D, Schaeffer E (Dec 1997). "COUP-TF and Sp1 interact and cooperate in the transcriptional activation of the human immunodeficiency virus type 1 long terminal repeat in human microglial cells" . The Journal of Biological Chemistry . 272 (49): 31149–55. doi :10.1074/jbc.272.49.31149 PMID 9388268 . Dressel U, Thormeyer D, Altincicek B, Paululat A, Eggert M, Schneider S, Tenbaum SP, Renkawitz R, Baniahmad A (May 1999). "Alien, a highly conserved protein with characteristics of a corepressor for members of the nuclear hormone receptor superfamily" . Molecular and Cellular Biology . 19 (5): 3383–94. doi :10.1128/mcb.19.5.3383 . PMC 84131 PMID 10207062 . Klinge CM, Kaur K, Swanson HI (Jan 2000). "The aryl hydrocarbon receptor interacts with estrogen receptor alpha and orphan receptors COUP-TFI and ERRalpha1". Archives of Biochemistry and Biophysics . 373 (1): 163–74. doi :10.1006/abbi.1999.1552 . PMID 10620335 . Rohr O, Schwartz C, Hery C, Aunis D, Tardieu M, Schaeffer E (Jan 2000). "The nuclear receptor chicken ovalbumin upstream promoter transcription factor interacts with HIV-1 Tat and stimulates viral replication in human microglial cells" . The Journal of Biological Chemistry . 275 (4): 2654–60. doi :10.1074/jbc.275.4.2654 PMID 10644726 . Sugiyama T, Wang JC, Scott DK, Granner DK (Feb 2000). "Transcription activation by the orphan nuclear receptor, chicken ovalbumin upstream promoter-transcription factor I (COUP-TFI). Definition of the domain involved in the glucocorticoid response of the phosphoenolpyruvate carboxykinase gene" . The Journal of Biological Chemistry . 275 (5): 3446–54. doi :10.1074/jbc.275.5.3446 PMID 10652338 . Vlahou A, Flytzanis CN (Feb 2000). "Subcellular trafficking of the nuclear receptor COUP-TF in the early embryonic cell cycle" . Developmental Biology . 218 (2): 284–98. doi :10.1006/dbio.1999.9456 PMID 10656770 . Avram D, Fields A, Pretty On Top K, Nevrivy DJ, Ishmael JE, Leid M (Apr 2000). "Isolation of a novel family of C(2)H(2) zinc finger proteins implicated in transcriptional repression mediated by chicken ovalbumin upstream promoter transcription factor (COUP-TF) orphan nuclear receptors" . The Journal of Biological Chemistry . 275 (14): 10315–22. doi :10.1074/jbc.275.14.10315 PMC 2819356 PMID 10744719 . Gay F, Anglade I, Gong Z, Salbert G (Oct 2000). "The LIM/homeodomain protein islet-1 modulates estrogen receptor functions" . Molecular Endocrinology . 14 (10): 1627–48. doi :10.1210/me.14.10.1627 PMID 11043578 . You M, Fischer M, Cho WK, Crabb D (Feb 2002). "Transcriptional control of the human aldehyde dehydrogenase 2 promoter by hepatocyte nuclear factor 4: inhibition by cyclic AMP and COUP transcription factors" . Archives of Biochemistry and Biophysics . 398 (1): 79–86. doi :10.1006/abbi.2001.2713 PMID 11811951 . Lin F, Kolluri SK, Chen GQ, Zhang XK (Jun 2002). "Regulation of retinoic acid-induced inhibition of AP-1 activity by orphan receptor chicken ovalbumin upstream promoter-transcription factor" . The Journal of Biological Chemistry . 277 (24): 21414–22. doi :10.1074/jbc.M201885200 PMID 11934895 . Métivier R, Gay FA, Hübner MR, Flouriot G, Salbert G, Gannon F, Kah O, Pakdel F (Jul 2002). "Formation of an hER alpha-COUP-TFI complex enhances hER alpha AF-1 through Ser118 phosphorylation by MAPK" . The EMBO Journal . 21 (13): 3443–53. doi :10.1093/emboj/cdf344 . PMC 126093 PMID 12093745 . Yu X, Mertz JE (Feb 2003). "Distinct modes of regulation of transcription of hepatitis B virus by the nuclear receptors HNF4alpha and COUP-TF1" . Journal of Virology . 77 (4): 2489–99. doi :10.1128/JVI.77.4.2489-2499.2003 . PMC 141100 PMID 12551987 .
This article incorporates text from the United States National Library of Medicine , which is in the public domain .
(1) Basic domains
(1.1) Basic leucine zipper (bZIP )(1.2) Basic helix-loop-helix (bHLH )
Group A Group B Group CPAS Group D Group E Group F
(1.3) bHLH-ZIP (1.4) NF-1 (1.5) RF-X (1.6) Basic helix-span-helix (bHSH)
(2) Zinc finger DNA-binding domains
(2.1) Nuclear receptor (Cys4 )
subfamily 1 subfamily 2 subfamily 3 subfamily 4 subfamily 5 subfamily 6 subfamily 0
(2.2) Other Cys4 (2.3) Cys2 His2 (2.4) Cys6 (2.5) Alternating composition (2.6) WRKY
(4) β-Scaffold factors with minor groove contacts
(0) Other transcription factors
