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If the compound lacks blood-brain-barrier penetration, can it really be classed with the template below it as being a CNS (central-nervous system) stimulant? This reminds me of the case with Loperamide, it is not CNS functional because it does not cross the BBB but is technically an opioid; but it is not a CNS depressant. RTI-371 should certainly not be classed a stimulant if it is not active across the BBB. Nagelfar (talk) 13:53, 16 October 2009 (UTC)[reply]