Sergei Makarov or Sergey Makarov may refer to:
- Sergei Makarov (ice hockey, born 1958), Russian ice hockey right winger and two-time Olympic gold medalist
- Sergei Makarov (ice hockey, born 1964), Russian ice hockey defenceman
- Sergey Makarov (javelin thrower) (born 1973), Russian javelin thrower
- Sergey Makarov (volleyball), Russian volleyball player
- Sergei Makarov (footballer) (born 1996), Russian football midfielder