THC Science

PHF1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2E5P, 2M0O, 4HCZ
Identifiers
Aliases	PHF1, MTF2L2, PCL1, PHF2, TDRD19C, hPHD finger protein 1
External IDs	OMIM: 602881 MGI: 98647 HomoloGene: 7567 GeneCards: PHF1
Gene location (Human)
Chr.	Chromosome 6 (human)
End	33,416,453 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	27,156,882 bp
RNA expression pattern
	Top expressed in
	Top expressed in
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function
Cellular component
Biological process
	Sources:Amigo / QuickGO
Orthologs
	5252
	21652
	ENSG00000112511; ENSG00000225553; ENSG00000239756
	ENSMUSG00000024193
	O43189
	Q9Z1B8
	NM_002636; NM_024165
	NM_009343; NM_001302397
	NP_002627; NP_077084
	NP_001289326; NP_033369
	Wikidata
View/Edit Human	View/Edit Mouse

PHD finger protein 1 is a protein that in humans is encoded by the PHF1 gene.^[5]^[6]^[7]

Function[edit]

This gene encodes a protein with significant sequence similarity to Drosophila Polycomblike. The encoded protein contains a zinc finger-like PHD (plant homeodomain) finger which is distinct from other classes of zinc finger motifs and which shows the typical Cys4-His-Cys3 arrangement. PHD finger genes are thought to belong to a diverse group of transcriptional regulators possibly affecting eukaryotic gene expression by influencing chromatin structure. Two transcript variants have been found for this gene.^[7]

References[edit]

^ ^a ^b ^c ENSG00000225553, ENSG00000239756 GRCh38: Ensembl release 89: ENSG00000112511, ENSG00000225553, ENSG00000239756 - Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000024193 - Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Coulson M, Robert S, Eyre HJ, Saint R (March 1998). "The identification and localization of a human gene with sequence similarity to Polycomblike of Drosophila melanogaster". Genomics. 48 (3): 381–3. doi:10.1006/geno.1997.5201. PMID 9545646.
^ Hong Z, Jiang J, Lan L, Nakajima S, Kanno S, Koseki H, Yasui A (May 2008). "A polycomb group protein, PHF1, is involved in the response to DNA double-strand breaks in human cell". Nucleic Acids Research. 36 (9): 2939–47. doi:10.1093/nar/gkn146. PMC 2396414. PMID 18385154.
^ ^a ^b "Entrez Gene: PHF1 PHD finger protein 1".

External links[edit]

PHF1+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

[refGRCh38Ensembl-1] ENSG00000225553, ENSG00000239756 GRCh38: Ensembl release 89: ENSG00000112511, ENSG00000225553, ENSG00000239756 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000024193 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9545646-5] Coulson M, Robert S, Eyre HJ, Saint R (March 1998). "The identification and localization of a human gene with sequence similarity to Polycomblike of Drosophila melanogaster". Genomics. 48 (3): 381–3. doi:10.1006/geno.1997.5201. PMID 9545646.

[pmid18385154-6] Hong Z, Jiang J, Lan L, Nakajima S, Kanno S, Koseki H, Yasui A (May 2008). "A polycomb group protein, PHF1, is involved in the response to DNA double-strand breaks in human cell". Nucleic Acids Research. 36 (9): 2939–47. doi:10.1093/nar/gkn146. PMC 2396414. PMID 18385154.

[entrez-7] "Entrez Gene: PHF1 PHD finger protein 1".

[1]

[2]

[3]

[4]

[5]

[6]

[7]

THC Science

Bringing Science to the Cannabis Conversation!

Cannabis Ruderalis

Function[edit]

References[edit]

Further reading[edit]

External links[edit]

Leave a Reply