Migraine is a debilitating condition characterized by headaches and nausea.

Migraine may also refer to:

• Migraine (book), a book by neurologist Oliver Sacks
• Project Migraine, a post-World War II U.S. Navy program to convert fleet submarines into radar picket submarines
• "Migraine" (song), a 2007 Tagalog-language song by Moonstar88
• "Migraine", a song by Twenty One Pilots from the album Vessel
• Migraine, a record label from NYC, set up by Teenage Jesus and the Jerks