Protein-coding gene in the species Homo sapiens
GTF2F1 Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1F3U , 1I27 , 1J2X , 1NHA , 1ONV , 2K7L , 5IY9 , 5IYA , 5IYC , 5IYB , 5IY7 , 5IY8 , 5IYD , 5IY6
Identifiers Aliases GTF2F1 External IDs OMIM : 189968 MGI : 1923848 HomoloGene : 1585 GeneCards : GTF2F1 Wikidata
General transcription factor IIF subunit 1 is a protein that in humans is encoded by the GTF2F1 gene .[5] [6]
Interactions [ edit ] GTF2F1 has been shown to interact with:
See also [ edit ] References [ edit ]
^ a b c GRCh38: Ensembl release 89: ENSG00000125651 - Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000002658 - Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Finkelstein A, Kostrub CF, Li J, Chavez DP, Wang BQ, Fang SM, Greenblatt J, Burton ZF (March 1992). "A cDNA encoding RAP74, a general initiation factor for transcription by RNA polymerase II". Nature . 355 (6359): 464–7. Bibcode :1992Natur.355..464F . doi :10.1038/355464a0 . PMID 1734284 . S2CID 1241044 . ^ "Entrez Gene: GTF2F1 general transcription factor IIF, polypeptide 1, 74kDa" .^ Archambault J, Pan G, Dahmus GK, Cartier M, Marshall N, Zhang S, Dahmus ME, Greenblatt J (October 1998). "FCP1, the RAP74-interacting subunit of a human protein phosphatase that dephosphorylates the carboxyl-terminal domain of RNA polymerase IIO" . J. Biol. Chem . 273 (42): 27593–601. doi :10.1074/jbc.273.42.27593 PMID 9765293 . ^ a b c d e f Scully R, Anderson SF, Chao DM, Wei W, Ye L, Young RA, Livingston DM, Parvin JD (May 1997). "BRCA1 is a component of the RNA polymerase II holoenzyme" . Proc. Natl. Acad. Sci. U.S.A . 94 (11): 5605–10. Bibcode :1997PNAS...94.5605S . doi :10.1073/pnas.94.11.5605 PMC 20825 PMID 9159119 . ^ Kim MK, Nikodem VM (October 1999). "hnRNP U inhibits carboxy-terminal domain phosphorylation by TFIIH and represses RNA polymerase II elongation" . Mol. Cell. Biol . 19 (10): 6833–44. doi :10.1128/MCB.19.10.6833 . PMC 84680 PMID 10490622 . ^ Suñé C, Hayashi T, Liu Y, Lane WS, Young RA, Garcia-Blanco MA (October 1997). "CA150, a nuclear protein associated with the RNA polymerase II holoenzyme, is involved in Tat-activated human immunodeficiency virus type 1 transcription" . Mol. Cell. Biol . 17 (10): 6029–39. doi :10.1128/MCB.17.10.6029 . PMC 232452 PMID 9315662 . ^ Cho H, Orphanides G, Sun X, Yang XJ, Ogryzko V, Lees E, Nakatani Y, Reinberg D (September 1998). "A human RNA polymerase II complex containing factors that modify chromatin structure" . Mol. Cell. Biol . 18 (9): 5355–63. doi :10.1128/MCB.18.9.5355 . PMC 109120 PMID 9710619 . ^ Joliot V, Demma M, Prywes R (February 1995). "Interaction with RAP74 subunit of TFIIF is required for transcriptional activation by serum response factor". Nature . 373 (6515): 632–5. Bibcode :1995Natur.373..632J . doi :10.1038/373632a0 . PMID 7854423 . S2CID 47196160 . ^ Zhu H, Joliot V, Prywes R (February 1994). "Role of transcription factor TFIIF in serum response factor-activated transcription" . J. Biol. Chem . 269 (5): 3489–97. doi :10.1016/S0021-9258(17)41889-8 PMID 8106390 . ^ Dikstein R, Ruppert S, Tjian R (March 1996). "TAFII250 is a bipartite protein kinase that phosphorylates the base transcription factor RAP74" . Cell . 84 (5): 781–90. doi :10.1016/s0092-8674(00)81055-7 PMID 8625415 . S2CID 18490534 . ^ a b Ruppert S, Tjian R (November 1995). "Human TAFII250 interacts with RAP74: implications for RNA polymerase II initiation" . Genes Dev . 9 (22): 2747–55. doi :10.1101/gad.9.22.2747 PMID 7590250 . ^ Siegert JL, Robbins PD (January 1999). "Rb inhibits the intrinsic kinase activity of TATA-binding protein-associated factor TAFII250" . Mol. Cell. Biol . 19 (1): 846–54. doi :10.1128/MCB.19.1.846 . PMC 83941 PMID 9858607 . ^ a b Malik S, Guermah M, Roeder RG (March 1998). "A dynamic model for PC4 coactivator function in RNA polymerase II transcription" . Proc. Natl. Acad. Sci. U.S.A . 95 (5): 2192–7. Bibcode :1998PNAS...95.2192M . doi :10.1073/pnas.95.5.2192 PMC 19292 PMID 9482861 . ^ Fang SM, Burton ZF (May 1996). "RNA polymerase II-associated protein (RAP) 74 binds transcription factor (TF) IIB and blocks TFIIB-RAP30 binding" . J. Biol. Chem . 271 (20): 11703–9. doi :10.1074/jbc.271.20.11703 PMID 8662660 .
Further reading [ edit ]
Kato H, Sumimoto H, Pognonec P, Chen CH, Rosen CA, Roeder RG (1992). "HIV-1 Tat acts as a processivity factor in vitro in conjunction with cellular elongation factors" . Genes Dev . 6 (4): 655–66. doi :10.1101/gad.6.4.655 PMID 1559613 . Aso T, Vasavada HA, Kawaguchi T, Germino FJ, Ganguly S, Kitajima S, Weissman SM, Yasukochi Y (1992). "Characterization of cDNA for the large subunit of the transcription initiation factor TFIIF". Nature . 355 (6359): 461–4. Bibcode :1992Natur.355..461A . doi :10.1038/355461a0 . PMID 1734283 . S2CID 4312708 . Adams MD, Kerlavage AR, Fleischmann RD, Fuldner RA, Bult CJ, Lee NH, Kirkness EF, Weinstock KG, Gocayne JD, White O (1995). "Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence". Nature . 377 (6547 Suppl): 3–174. PMID 7566098 . Ruppert S, Tjian R (1995). "Human TAFII250 interacts with RAP74: implications for RNA polymerase II initiation" . Genes Dev . 9 (22): 2747–55. doi :10.1101/gad.9.22.2747 PMID 7590250 . Hisatake K, Ohta T, Takada R, Guermah M, Horikoshi M, Nakatani Y, Roeder RG (1995). "Evolutionary conservation of human TATA-binding-polypeptide-associated factors TAFII31 and TAFII80 and interactions of TAFII80 with other TAFs and with general transcription factors" . Proc. Natl. Acad. Sci. U.S.A . 92 (18): 8195–9. Bibcode :1995PNAS...92.8195H . doi :10.1073/pnas.92.18.8195 PMC 41123 PMID 7667268 . Joliot V, Demma M, Prywes R (1995). "Interaction with RAP74 subunit of TFIIF is required for transcriptional activation by serum response factor". Nature . 373 (6515): 632–5. Bibcode :1995Natur.373..632J . doi :10.1038/373632a0 . PMID 7854423 . S2CID 47196160 . Zhu H, Joliot V, Prywes R (1994). "Role of transcription factor TFIIF in serum response factor-activated transcription" . J. Biol. Chem . 269 (5): 3489–97. doi :10.1016/S0021-9258(17)41889-8 PMID 8106390 . Yonaha M, Aso T, Kobayashi Y, Vasavada H, Yasukochi Y, Weissman SM, Kitajima S (1993). "Domain structure of a human general transcription initiation factor, TFIIF" . Nucleic Acids Res . 21 (2): 273–9. doi :10.1093/nar/21.2.273 . PMC 309103 PMID 8441635 . Aso T, Tsai P, Kawaguchi T, Menninger JC, Kitajima S, Yasukochi Y, Ward DC, Weissman SM (1993). "Assignment of the human GTF2F1 gene to chromosome 19p13.3" . Genomics . 16 (1): 252–3. doi :10.1006/geno.1993.1168 PMID 8486367 . Dikstein R, Ruppert S, Tjian R (1996). "TAFII250 is a bipartite protein kinase that phosphorylates the base transcription factor RAP74" . Cell . 84 (5): 781–90. doi :10.1016/S0092-8674(00)81055-7 PMID 8625415 . S2CID 18490534 . Fang SM, Burton ZF (1996). "RNA polymerase II-associated protein (RAP) 74 binds transcription factor (TF) IIB and blocks TFIIB-RAP30 binding" . J. Biol. Chem . 271 (20): 11703–9. doi :10.1074/jbc.271.20.11703 PMID 8662660 . McEwan IJ, Dahlman-Wright K, Ford J, Wright AP (1996). "Functional interaction of the c-Myc transactivation domain with the TATA binding protein: evidence for an induced fit model of transactivation domain folding". Biochemistry . 35 (29): 9584–93. doi :10.1021/bi960793v . PMID 8755740 . Zhou Q, Sharp PA (1996). "Tat-SF1: cofactor for stimulation of transcriptional elongation by HIV-1 Tat". Science . 274 (5287): 605–10. Bibcode :1996Sci...274..605Z . doi :10.1126/science.274.5287.605 . PMID 8849451 . S2CID 13266489 . Parada CA, Roeder RG (1996). "Enhanced processivity of RNA polymerase II triggered by Tat-induced phosphorylation of its carboxy-terminal domain". Nature . 384 (6607): 375–8. Bibcode :1996Natur.384..375P . doi :10.1038/384375a0 . PMID 8934526 . S2CID 4278432 . Cujec TP, Cho H, Maldonado E, Meyer J, Reinberg D, Peterlin BM (1997). "The human immunodeficiency virus transactivator Tat interacts with the RNA polymerase II holoenzyme" . Mol. Cell. Biol . 17 (4): 1817–23. doi :10.1128/mcb.17.4.1817 . PMC 232028 PMID 9121429 . Scully R, Anderson SF, Chao DM, Wei W, Ye L, Young RA, Livingston DM, Parvin JD (1997). "BRCA1 is a component of the RNA polymerase II holoenzyme" . Proc. Natl. Acad. Sci. U.S.A . 94 (11): 5605–10. Bibcode :1997PNAS...94.5605S . doi :10.1073/pnas.94.11.5605 PMC 20825 PMID 9159119 . McEwan IJ, Gustafsson J (1997). "Interaction of the human androgen receptor transactivation function with the general transcription factor TFIIF" . Proc. Natl. Acad. Sci. U.S.A . 94 (16): 8485–90. Bibcode :1997PNAS...94.8485M . doi :10.1073/pnas.94.16.8485 PMC 22967 PMID 9238003 . Newberry EP, Latifi T, Battaile JT, Towler DA (1997). "Structure-function analysis of Msx2-mediated transcriptional suppression". Biochemistry . 36 (34): 10451–62. doi :10.1021/bi971008x . PMID 9265625 . O'Brien T, Tjian R (1998). "Functional analysis of the human TAFII250 N-terminal kinase domain" . Mol. Cell . 1 (6): 905–11. doi :10.1016/S1097-2765(00)80089-1 PMID 9660973 .
External links [ edit ]
PDB gallery
1f3u : CRYSTAL STRUCTURE OF THE RAP30/74 INTERACTION DOMAINS OF HUMAN TFIIF
1i27 : CRYSTAL STRUCTURE OF THE C-TERMINAL DOMAIN OF THE RAP74 SUBUNIT OF HUMAN TRANSCRIPTION FACTOR IIF (TFIIF)
1j2x : Crystal structure of RAP74 C-terminal domain complexed with FCP1 C-terminal peptide
1nha : Solution Structure of the Carboxyl-Terminal Domain of RAP74 and NMR Characterization of the FCP-Binding Sites of RAP74 and CTD of RAP74, the subunit of Human TFIIF
1onv : NMR Structure of a Complex Containing the TFIIF Subunit RAP74 and the RNAP II CTD Phosphatase FCP1
(1) Basic domains
(1.1) Basic leucine zipper (bZIP )(1.2) Basic helix-loop-helix (bHLH )
Group A Group B Group CPAS Group D Group E Group F
(1.3) bHLH-ZIP (1.4) NF-1 (1.5) RF-X (1.6) Basic helix-span-helix (bHSH)
(2) Zinc finger DNA-binding domains
(2.1) Nuclear receptor (Cys4 )
subfamily 1 subfamily 2 subfamily 3 subfamily 4 subfamily 5 subfamily 6 subfamily 0
(2.2) Other Cys4 (2.3) Cys2 His2 (2.4) Cys6 (2.5) Alternating composition (2.6) WRKY
(4) β-Scaffold factors with minor groove contacts
(0) Other transcription factors
This article incorporates text from the United States National Library of Medicine , which is in the public domain .
