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Original file ‎(SVG file, nominally 385 × 385 pixels, file size: 185 KB)

Summary

 
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Description
English: Simplified schematic of the key pathways of paracetamol metabolism in the human body. The first step in conversion of paracetamol to NAPQI has been omitted for clarity.
Set in Myriad Pro.
Legend
 
Pathways to non-toxic metabolites
 
Pathway to toxic metabolites (CYP-mediated)
 
Detoxification pathway
Abbreviations
GlcA, glucuronic acid; GSH, glutathione; NAPQI, N-acetyl-p-benzoquinone imine.
Português: Esquema simplificado das principais vias de biotransformação do paracetamol em humanos. Para maior clareza, omitiu-se a primeira etapa da conversão do paracetamol à N-acetil-benzoquinoneimina.
Diagrama composto em Myriad Pro.
Legenda
 
Vias de conversão a metabólitos atóxicos
 
Via de conversão a metabólitos tóxicos (mediada pelo sistema P450)
 
Via de detoxificação
Abreviações
GlcA, ácido glicurônico; GSH, glutationa; NAPQI, N-acetil-benzoquinoneimina.
 
This W3C-unspecified vector image was created with Inkscape .
Date
Source Own work, after Henry, John (1995). “Poisoning”, in Marshall, William Leonard. Clinical biochemistry: metabolic and clinical aspects, p. 666, Edinburgh: Churchill Livingstone, ISBN 9780443043413; and Hendrickson, Robert G.; Kenneth E. Bizovi (2006). “Acetaminophen”, in Nelson, Lewis H.; Flomenbaum, Neal; Goldfrank, Lewis R. et al. Goldfrank's toxicologic emergencies, p. 525, New York: McGraw-Hill, ISBN 9780071437639. Both retrieved on January 18, 2009 through Google Book Search.
Author Fvasconcellos (talk · contribs)
Permission
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Public domain I, the copyright holder of this work, release this work into the public domain. This applies worldwide.
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Other versions

Derivative works of this file:  Paracetamol metabolism it.svg

File:Paracetamol metabolism.png (English, also simpified)
File:Métabolisme paracetamol.png (French, also simplified)
File:Metabolizm paracetamolu.svg (more detailed, Polish)

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metabolic pathway of paracetamol

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inception

18 January 2009

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Date/TimeThumbnailDimensionsUserComment
current13:13, 19 January 2009Thumbnail for version as of 13:13, 19 January 2009385 × 385 (185 KB)Fvasconcellosfixed NAPQI structure
17:47, 18 January 2009Thumbnail for version as of 17:47, 18 January 2009385 × 385 (185 KB)Fvasconcellosalignment
16:15, 18 January 2009Thumbnail for version as of 16:15, 18 January 2009385 × 385 (191 KB)Fvasconcellos== Summary == {{validSVG}} {{Information |Description= {{en|Simplified schematic of the key pathways of {{w|paracetamol}} metabolism in the human body. The first step in conversion of paracetamol to NAPQI has been omitted for clari
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