Protein-coding gene in the species Homo sapiens
Transcription factor E2F5 is a protein that in humans is encoded by the E2F5 gene .[5] [6]
Function [ edit ] The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionarily conserved domains that are present in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein is differentially phosphorylated and is expressed in a wide variety of human tissues. It has higher identity to E2F4 than to other family members. Both this protein and E2F4 interact with tumor suppressor proteins p130 and p107, but not with pRB. Alternative splicing results in multiple variants encoding different isoforms.[6]
Interactions [ edit ] E2F5 has been shown to interact with TFDP1 .[5] [7]
See also [ edit ] References [ edit ]
^ a b c GRCh38: Ensembl release 89: ENSG00000133740 - Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000027552 - Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ a b Sardet C, Vidal M, Cobrinik D, Geng Y, Onufryk C, Chen A, Weinberg RA (Mar 1995). "E2F-4 and E2F-5, two members of the E2F family, are expressed in the early phases of the cell cycle" . Proceedings of the National Academy of Sciences of the United States of America . 92 (6): 2403–7. Bibcode :1995PNAS...92.2403S . doi :10.1073/pnas.92.6.2403 PMC 42492 PMID 7892279 . ^ a b "Entrez Gene: E2F5 E2F transcription factor 5, p130-binding" .^ Hijmans EM, Voorhoeve PM, Beijersbergen RL, van 't Veer LJ, Bernards R (Jun 1995). "E2F-5, a new E2F family member that interacts with p130 in vivo" . Molecular and Cellular Biology . 15 (6): 3082–9. doi :10.1128/mcb.15.6.3082 . PMC 230539 PMID 7760804 .
Further reading [ edit ]
Hijmans EM, Voorhoeve PM, Beijersbergen RL, van 't Veer LJ, Bernards R (Jun 1995). "E2F-5, a new E2F family member that interacts with p130 in vivo" . Molecular and Cellular Biology . 15 (6): 3082–9. doi :10.1128/mcb.15.6.3082 . PMC 230539 PMID 7760804 . Ginsberg D, Vairo G, Chittenden T, Xiao ZX, Xu G, Wydner KL, DeCaprio JA, Lawrence JB, Livingston DM (Nov 1994). "E2F-4, a new member of the E2F transcription factor family, interacts with p107" . Genes & Development . 8 (22): 2665–79. doi :10.1101/gad.8.22.2665 PMID 7958924 . Beijersbergen RL, Kerkhoven RM, Zhu L, Carlée L, Voorhoeve PM, Bernards R (Nov 1994). "E2F-4, a new member of the E2F gene family, has oncogenic activity and associates with p107 in vivo" . Genes & Development . 8 (22): 2680–90. doi :10.1101/gad.8.22.2680 PMID 7958925 . Itoh A, Levinson SF, Morita T, Kourembanas S, Brody JS, Mitsialis SA (1996). "Structural characterization and specificity of expression of E2F-5: a new member of the E2F family of transcription factors". Cellular & Molecular Biology Research . 41 (3): 147–54. PMID 8589754 . Lindeman GJ, Gaubatz S, Livingston DM, Ginsberg D (May 1997). "The subcellular localization of E2F-4 is cell-cycle dependent" . Proceedings of the National Academy of Sciences of the United States of America . 94 (10): 5095–100. Bibcode :1997PNAS...94.5095L . doi :10.1073/pnas.94.10.5095 PMC 24637 PMID 9144196 . Vaishnav YN, Vaishnav MY, Pant V (Jan 1998). "The molecular and functional characterization of E2F-5 transcription factor". Biochemical and Biophysical Research Communications . 242 (3): 586–92. doi :10.1006/bbrc.1997.8010 . PMID 9464260 . Morris L, Allen KE, La Thangue NB (Apr 2000). "Regulation of E2F transcription by cyclin E-Cdk2 kinase mediated through p300/CBP co-activators". Nature Cell Biology . 2 (4): 232–9. doi :10.1038/35008660 . PMID 10783242 . S2CID 36134762 . Gaubatz S, Lindeman GJ, Ishida S, Jakoi L, Nevins JR, Livingston DM, Rempel RE (Sep 2000). "E2F4 and E2F5 play an essential role in pocket protein-mediated G1 control" . Molecular Cell . 6 (3): 729–35. doi :10.1016/S1097-2765(00)00071-X PMID 11030352 . D'Souza SJ, Pajak A, Balazsi K, Dagnino L (Jun 2001). "Ca2+ and BMP-6 signaling regulate E2F during epidermal keratinocyte differentiation" . The Journal of Biological Chemistry . 276 (26): 23531–8. doi :10.1074/jbc.M100780200 PMID 11319226 . Chestukhin A, Litovchick L, Rudich K, DeCaprio JA (Jan 2002). "Nucleocytoplasmic shuttling of p130/RBL2: novel regulatory mechanism" . Molecular and Cellular Biology . 22 (2): 453–68. doi :10.1128/MCB.22.2.453-468.2002 . PMC 139733 PMID 11756542 . Apostolova MD, Ivanova IA, Dagnino C, D'Souza SJ, Dagnino L (Sep 2002). "Active nuclear import and export pathways regulate E2F-5 subcellular localization" . The Journal of Biological Chemistry . 277 (37): 34471–9. doi :10.1074/jbc.M205827200 PMID 12089160 . Chen CR, Kang Y, Siegel PM, Massagué J (Jul 2002). "E2F4/5 and p107 as Smad cofactors linking the TGFbeta receptor to c-myc repression" . Cell . 110 (1): 19–32. doi :10.1016/S0092-8674(02)00801-2 PMID 12150994 . S2CID 8945574 . Macaluso M, Cinti C, Russo G, Russo A, Giordano A (Jun 2003). "pRb2/p130-E2F4/5-HDAC1-SUV39H1-p300 and pRb2/p130-E2F4/5-HDAC1-SUV39H1-DNMT1 multimolecular complexes mediate the transcription of estrogen receptor-alpha in breast cancer" . Oncogene . 22 (23): 3511–7. doi :10.1038/sj.onc.1206578 PMID 12789259 . Ohtani N, Brennan P, Gaubatz S, Sanij E, Hertzog P, Wolvetang E, Ghysdael J, Rowe M, Hara E (Jul 2003). "Epstein-Barr virus LMP1 blocks p16INK4a-RB pathway by promoting nuclear export of E2F4/5" . The Journal of Cell Biology . 162 (2): 173–83. doi :10.1083/jcb.200302085 . PMC 2172795 PMID 12860972 . Brandenberger R, Wei H, Zhang S, Lei S, Murage J, Fisk GJ, Li Y, Xu C, Fang R, Guegler K, Rao MS, Mandalam R, Lebkowski J, Stanton LW (Jun 2004). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nature Biotechnology . 22 (6): 707–16. doi :10.1038/nbt971 . PMID 15146197 . S2CID 27764390 . Jiang Y, Saavedra HI, Holloway MP, Leone G, Altura RA (Sep 2004). "Aberrant regulation of survivin by the RB/E2F family of proteins" . The Journal of Biological Chemistry . 279 (39): 40511–20. doi :10.1074/jbc.M404496200 PMID 15271987 . Suzuki Y, Yamashita R, Shirota M, Sakakibara Y, Chiba J, Mizushima-Sugano J, Nakai K, Sugano S (Sep 2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions" . Genome Research . 14 (9): 1711–8. doi :10.1101/gr.2435604 . PMC 515316 PMID 15342556 . Joshi B, Ordonez-Ercan D, Dasgupta P, Chellappan S (Mar 2005). "Induction of human metallothionein 1G promoter by VEGF and heavy metals: differential involvement of E2F and metal transcription factors" . Oncogene . 24 (13): 2204–17. doi :10.1038/sj.onc.1208206 PMID 15735762 . Swetloff A, Ferretti P (2006). "Changes in E2F5 intracellular localization in mouse and human choroid plexus epithelium with development" . The International Journal of Developmental Biology . 49 (7): 859–65. doi :10.1387/ijdb.051996as PMID 16172982 .
External links [ edit ] This article incorporates text from the United States National Library of Medicine , which is in the public domain .
(1) Basic domains
(1.1) Basic leucine zipper (bZIP )(1.2) Basic helix-loop-helix (bHLH )
Group A Group B Group CPAS Group D Group E Group F
(1.3) bHLH-ZIP (1.4) NF-1 (1.5) RF-X (1.6) Basic helix-span-helix (bHSH)
(2) Zinc finger DNA-binding domains
(2.1) Nuclear receptor (Cys4 )
subfamily 1 subfamily 2 subfamily 3 subfamily 4 subfamily 5 subfamily 6 subfamily 0
(2.2) Other Cys4 (2.3) Cys2 His2 (2.4) Cys6 (2.5) Alternating composition (2.6) WRKY
(4) β-Scaffold factors with minor groove contacts
(0) Other transcription factors
