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ZNF43
Identifiers
Aliases	ZNF43, HTF6, KOX27, ZNF39L1, zinc finger protein 43
External IDs	OMIM: 603972 MGI: 3040691 HomoloGene: 128170 GeneCards: ZNF43
Gene location (Human)
Chr.	Chromosome 19 (human)
End	21,852,125 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	67,278,466 bp
RNA expression pattern
	Top expressed in
	Top expressed in
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function
Cellular component
Biological process
	Sources:Amigo / QuickGO
Orthologs
	7594
	238690
	ENSG00000198521; ENSG00000279566
	ENSMUSG00000055480
	P17038
	Q6P5C7
NM_001256648; NM_001256649; NM_001256650; NM_001256651; NM_001256653;
	NM_001256654; NM_003423
	NM_001001152
NP_001243577; NP_001243578; NP_001243579; NP_001243580; NP_001243582;
	NP_001243583; NP_003414; NP_001243577.1; NP_001243578.1; NP_001243579.1
	NP_001001152
	Wikidata
View/Edit Human	View/Edit Mouse

Zinc finger protein 43 is a protein that in humans is encoded by the ZNF43 gene.^[5]^[6]

Function[edit]

This gene belongs to the C2H2-type zinc finger gene family. The zinc finger proteins are involved in gene regulation and development, and are quite conserved throughout evolution. Like this gene product, a third of the zinc finger proteins containing C2H2 fingers also contain the KRAB domain, which has been found to be involved in protein-protein interactions.^[6]

References[edit]

^ ^a ^b ^c ENSG00000279566 GRCh38: Ensembl release 89: ENSG00000198521, ENSG00000279566 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000055480 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Lovering R, Trowsdale J (Jun 1991). "A gene encoding 22 highly related zinc fingers is expressed in lymphoid cell lines". Nucleic Acids Research. 19 (11): 2921–8. doi:10.1093/nar/19.11.2921. PMC 328252. PMID 1711675.
^ ^a ^b "Entrez Gene: ZNF43 zinc finger protein 43".

Further reading[edit]

Huebner K, Druck T, Croce CM, Thiesen HJ (Apr 1991). "Twenty-seven nonoverlapping zinc finger cDNAs from human T cells map to nine different chromosomes with apparent clustering". American Journal of Human Genetics. 48 (4): 726–40. PMC 1682948. PMID 2014798.
Bellefroid EJ, Poncelet DA, Lecocq PJ, Revelant O, Martial JA (May 1991). "The evolutionarily conserved Krüppel-associated box domain defines a subfamily of eukaryotic multifingered proteins". Proceedings of the National Academy of Sciences of the United States of America. 88 (9): 3608–12. Bibcode:1991PNAS...88.3608B. doi:10.1073/pnas.88.9.3608. PMC 51501. PMID 2023909.
Thiesen HJ (Apr 1990). "Multiple genes encoding zinc finger domains are expressed in human T cells". The New Biologist. 2 (4): 363–74. PMID 2288909.
Bellefroid EJ, Marine JC, Ried T, Lecocq PJ, Rivière M, Amemiya C, Poncelet DA, Coulie PG, de Jong P, Szpirer C (Apr 1993). "Clustered organization of homologous KRAB zinc-finger genes with enhanced expression in human T lymphoid cells". The EMBO Journal. 12 (4): 1363–74. doi:10.1002/j.1460-2075.1993.tb05781.x. PMC 413348. PMID 8467795.
Hartley JL, Temple GF, Brasch MA (Nov 2000). "DNA cloning using in vitro site-specific recombination". Genome Research. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
Simpson JC, Wellenreuther R, Poustka A, Pepperkok R, Wiemann S (Sep 2000). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Reports. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, Bechtel S, Sauermann M, Korf U, Pepperkok R, Sültmann H, Poustka A (Oct 2004). "From ORFeome to biology: a functional genomics pipeline". Genome Research. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
Mehrle A, Rosenfelder H, Schupp I, del Val C, Arlt D, Hahne F, Bechtel S, Simpson J, Hofmann O, Hide W, Glatting KH, Huber W, Pepperkok R, Poustka A, Wiemann S (Jan 2006). "The LIFEdb database in 2006". Nucleic Acids Research. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
Takahashi T, Furuchi T, Naganuma A (Dec 2006). "Endocytic Ark/Prk kinases play a critical role in adriamycin resistance in both yeast and mammalian cells". Cancer Research. 66 (24): 11932–7. doi:10.1158/0008-5472.CAN-06-3220. PMID 17178891.

External links[edit]

ZNF43+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

[refGRCh38Ensembl-1] ENSG00000279566 GRCh38: Ensembl release 89: ENSG00000198521, ENSG00000279566 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000055480 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1711675-5] Lovering R, Trowsdale J (Jun 1991). "A gene encoding 22 highly related zinc fingers is expressed in lymphoid cell lines". Nucleic Acids Research. 19 (11): 2921–8. doi:10.1093/nar/19.11.2921. PMC 328252. PMID 1711675.

[entrez-6] "Entrez Gene: ZNF43 zinc finger protein 43".

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