For the TCF1 gene, see
HNF1A .
Protein-coding gene in the species Homo sapiens
Transcription factor 7 is the gene that in humans encodes for the TCF1 protein .[5]
References [ edit ] Further reading [ edit ]
van de Wetering M, Oosterwegel M, Holstege F, et al. (1992). "The human T cell transcription factor-1 gene. Structure, localization, and promoter characterization" . J. Biol. Chem . 267 (12): 8530–6. doi :10.1016/S0021-9258(18)42476-3 PMID 1569101 . van de Wetering M, Oosterwegel M, Dooijes D, Clevers H (1991). "Identification and cloning of TCF-1, a T lymphocyte-specific transcription factor containing a sequence-specific HMG box" . EMBO J . 10 (1): 123–32. doi :10.1002/j.1460-2075.1991.tb07928.x . PMC 452620 PMID 1989880 . Castrop J, van Wichen D, Koomans-Bitter M, et al. (1995). "The human TCF-1 gene encodes a nuclear DNA-binding protein uniquely expressed in normal and neoplastic T-lineage lymphocytes" . Blood . 86 (8): 3050–9. doi :10.1182/blood.V86.8.3050.3050 hdl :20.500.11755/05a0e0d7-f80c-4035-a8da-056c8b5b7883 PMID 7579399 . Mayer K, Wolff E, Clevers H, Ballhausen WG (1995). "The human high mobility group (HMG)-box transcription factor TCF-1: novel isoforms due to alternative splicing and usage of a new exon IXA". Biochim. Biophys. Acta . 1263 (2): 169–72. doi :10.1016/0167-4781(95)00108-s . PMID 7640309 . Van de Wetering M, Castrop J, Korinek V, Clevers H (1996). "Extensive alternative splicing and dual promoter usage generate Tcf-1 protein isoforms with differential transcription control properties" . Mol. Cell. Biol . 16 (3): 745–52. doi :10.1128/mcb.16.3.745 . PMC 231054 PMID 8622675 . Korinek V, Barker N, Willert K, et al. (1998). "Two members of the Tcf family implicated in Wnt/beta-catenin signaling during embryogenesis in the mouse" . Mol. Cell. Biol . 18 (3): 1248–56. doi :10.1128/MCB.18.3.1248 . PMC 108837 PMID 9488439 . Roose J, Molenaar M, Peterson J, et al. (1998). "The Xenopus Wnt effector XTcf-3 interacts with Groucho-related transcriptional repressors". Nature . 395 (6702): 608–12. Bibcode :1998Natur.395..608R . doi :10.1038/26989 . PMID 9783587 . S2CID 4347003 . Roose J, Huls G, van Beest M, et al. (1999). "Synergy between tumor suppressor APC and the beta-catenin-Tcf4 target Tcf1". Science . 285 (5435): 1923–6. doi :10.1126/science.285.5435.1923 . PMID 10489374 . Brantjes H, Roose J, van De Wetering M, Clevers H (2001). "All Tcf HMG box transcription factors interact with Groucho-related co-repressors" . Nucleic Acids Res . 29 (7): 1410–9. doi :10.1093/nar/29.7.1410 . PMC 31284 PMID 11266540 . Batlle E, Henderson JT, Beghtel H, et al. (2002). "Beta-catenin and TCF mediate cell positioning in the intestinal epithelium by controlling the expression of EphB/ephrinB" . Cell . 111 (2): 251–63. doi :10.1016/S0092-8674(02)01015-2 PMID 12408869 . S2CID 10103038 . Noble JA, White AM, Lazzeroni LC, et al. (2003). "A polymorphism in the TCF7 gene, C883A, is associated with type 1 diabetes" . Diabetes . 52 (6): 1579–82. doi :10.2337/diabetes.52.6.1579 PMID 12765974 . Ioannidis V, Kunz B, Tanamachi DM, et al. (2003). "Initiation and limitation of Ly-49A NK cell receptor acquisition by T cell factor-1" . J. Immunol . 171 (2): 769–75. doi :10.4049/jimmunol.171.2.769 PMID 12847244 . Smit L, Baas A, Kuipers J, et al. (2004). "Wnt activates the Tak1/Nemo-like kinase pathway" . J. Biol. Chem . 279 (17): 17232–40. doi :10.1074/jbc.M307801200 PMID 14960582 . Smith SS, Patterson T, Pauza ME (2005). "Transgenic Ly-49A inhibits antigen-driven T cell activation and delays diabetes" . J. Immunol . 174 (7): 3897–905. doi :10.4049/jimmunol.174.7.3897 PMID 15778344 . Willinger T, Freeman T, Herbert M, et al. (2006). "Human naive CD8 T cells down-regulate expression of the WNT pathway transcription factors lymphoid enhancer binding factor 1 and transcription factor 7 (T cell factor-1) following antigen encounter in vitro and in vivo" . J. Immunol . 176 (3): 1439–46. doi :10.4049/jimmunol.176.3.1439 PMID 16424171 .
(1) Basic domains
(1.1) Basic leucine zipper (bZIP )(1.2) Basic helix-loop-helix (bHLH )
Group A Group B Group CPAS Group D Group E Group F
(1.3) bHLH-ZIP (1.4) NF-1 (1.5) RF-X (1.6) Basic helix-span-helix (bHSH)
(2) Zinc finger DNA-binding domains
(2.1) Nuclear receptor (Cys4 )
subfamily 1 subfamily 2 subfamily 3 subfamily 4 subfamily 5 subfamily 6 subfamily 0
(2.2) Other Cys4 (2.3) Cys2 His2 (2.4) Cys6 (2.5) Alternating composition (2.6) WRKY
(4) β-Scaffold factors with minor groove contacts
(0) Other transcription factors
