Relaxin/insulin-like family peptide receptor 1, also known as RXFP1, is a human G protein coupled receptor that is one of the relaxin receptors.[5] It is a rhodopsin-like GPCR which is unusual in this class as it contains a large extracellular binding and signalling domain.[6] Some reports suggest that RXFP1 forms homodimers,[7][8] however the most recent evidence indicates that relaxin binds a non-homodimer of RXFP1.[9][10]
Bathgate RA, Ivell R, Sanborn BM, Sherwood OD, Summers RJ (March 2006). "International Union of Pharmacology LVII: recommendations for the nomenclature of receptors for relaxin family peptides". Pharmacological Reviews. 58 (1): 7–31. doi:10.1124/pr.58.1.9. PMID16507880. S2CID7466039.
Liu C, Chen J, Kuei C, Sutton S, Nepomuceno D, Bonaventure P, Lovenberg TW (January 2005). "Relaxin-3/insulin-like peptide 5 chimeric peptide, a selective ligand for G protein-coupled receptor (GPCR)135 and GPCR142 over leucine-rich repeat-containing G protein-coupled receptor 7". Molecular Pharmacology. 67 (1): 231–40. doi:10.1124/mol.104.006700. PMID15465925. S2CID25164369.
Scott DJ, Layfield S, Riesewijk A, Morita H, Tregear GW, Bathgate RA (November 2004). "Identification and characterization of the mouse and rat relaxin receptors as the novel orthologues of human leucine-rich repeat-containing G-protein-coupled receptor 7". Clinical and Experimental Pharmacology & Physiology. 31 (11): 828–32. doi:10.1111/j.1440-1681.2004.04075.x. PMID15566402. S2CID22463239.
Hopkins EJ, Bathgate RA, Gooley PR (May 2005). "The human LGR7 low-density lipoprotein class A module requires calcium for structure". Annals of the New York Academy of Sciences. 1041: 27–34. doi:10.1196/annals.1282.006. PMID15956684. S2CID12876694.
Bond CP, Parry LJ, Samuel CS, Gehring HM, Lederman FL, Rogers PA, Summers RJ (May 2005). "Increased expression of the relaxin receptor (LGR7) in human endometrium during the secretory phase of the menstrual cycle". Annals of the New York Academy of Sciences. 1041: 136–43. doi:10.1196/annals.1282.020. PMID15956698. S2CID38242216.
Halls ML, Bathgate RA, Summers RJ (May 2005). "Signal switching after stimulation of LGR7 receptors by human relaxin 2". Annals of the New York Academy of Sciences. 1041: 288–91. doi:10.1196/annals.1282.042. PMID15956719. S2CID42606513.