RNASEH2C
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3P56, 3PUF
Identifiers
Aliases	RNASEH2C, AGS3, AYP1, ribonuclease H2 subunit C
External IDs	OMIM: 610330 MGI: 1915459 HomoloGene: 32666 GeneCards: RNASEH2C
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11q13.1 Start 65,714,005 bp[1] End 65,720,818 bp[1]
Gene location (Mouse) Chr. Chromosome 19 (mouse)[2] Band 19|19 A Start 5,651,901 bp[2] End 5,657,047 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Top expressed in More reference expression data BioGPS n/a
Gene ontology Molecular function Cellular component Biological process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 84153 68209 Ensembl ENSG00000172922 ENSMUSG00000024925 UniProt Q8TDP1 Q9CQ18 RefSeq (mRNA) NM_032193 NM_026616 RefSeq (protein) NP_115569 NP_080892 Location (UCSC) Chr 11: 65.71 – 65.72 Mb Chr 19: 5.65 – 5.66 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Ribonuclease H2 subunit C is a protein that in humans is encoded by the RNASEH2C gene. ^[5] RNase H2 is composed of a single catalytic subunit (A) and two non-catalytic subunits (B and C), and degrades the RNA of RNA:DNA hybrids.

Mutations in this gene are a cause of Aicardi-Goutieres syndrome type 3 (AGS3).^[5][6]

Function[edit]

This gene encodes a ribonuclease H subunit that can cleave ribonucleotides from RNA:DNA duplexes. Mutations in this gene cause Aicardi-Goutieres syndrome-3, a disease that causes severe neurologic dysfunction. A pseudogene for this gene has been identified on chromosome Y, near the sex determining region Y (SRY) gene.

References[edit]

Further reading[edit]

External links[edit]

• Overview of all the structural information available in the PDB for UniProt: Q8TDP1 (Human Ribonuclease H2 subunit C (RNASEH2C)) at the PDBe-KB.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.