Protein-coding gene in the species Homo sapiens
G protein-coupled receptor 6 , also known as GPR6 , is a protein which in humans is encoded by the GPR6 gene .[5] [6]
Function [ edit ] GPR6 is a member of the G protein-coupled receptor family of transmembrane receptors . It has been reported that GPR6 is both constitutively active but in addition is further activated by sphingosine-1-phosphate .[7]
GPR6 up-regulates cyclic AMP levels and promotes neurite outgrowth.[8]
Inverse Agonist [ edit ] Evolution [ edit ] Source:[10]
See also [ edit ] References [ edit ]
^ a b c GRCh38: Ensembl release 89: ENSG00000146360 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000046922 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Entrez Gene: GPR6 G protein-coupled receptor 6" .^ Song ZH, Modi W, Bonner TI (July 1995). "Molecular cloning and chromosomal localization of human genes encoding three closely related G protein-coupled receptors" . Genomics . 28 (2): 347–349. doi :10.1006/geno.1995.1154 . PMID 8530049 . ^ Uhlenbrock K, Gassenhuber H, Kostenis E (November 2002). "Sphingosine 1-phosphate is a ligand of the human gpr3, gpr6 and gpr12 family of constitutively active G protein-coupled receptors". Cellular Signalling . 14 (11): 941–953. doi :10.1016/S0898-6568(02)00041-4 . PMID 12220620 . ^ Tanaka S, Ishii K, Kasai K, Yoon SO, Saeki Y (April 2007). "Neural expression of G protein-coupled receptors GPR3, GPR6, and GPR12 up-regulates cyclic AMP levels and promotes neurite outgrowth" . The Journal of Biological Chemistry . 282 (14): 10506–10515. doi :10.1074/jbc.M700911200 PMID 17284443 . ^ Laun AS, Shrader SH, Brown KJ, Song ZH (March 2019). "GPR3, GPR6, and GPR12 as novel molecular targets: their biological functions and interaction with cannabidiol" . Acta Pharmacologica Sinica . 40 (3): 300–308. doi :10.1038/s41401-018-0031-9 . PMC 6460361 PMID 29941868 . ^ "GeneCards®: The Human Gene Database" .
Further reading [ edit ]
Heiber M, Docherty JM, Shah G, Nguyen T, Cheng R, Heng HH, et al. (January 1995). "Isolation of three novel human genes encoding G protein-coupled receptors". DNA and Cell Biology . 14 (1): 25–35. doi :10.1089/dna.1995.14.25 . PMID 7832990 . Song ZH, Modi W, Bonner TI (July 1995). "Molecular cloning and chromosomal localization of human genes encoding three closely related G protein-coupled receptors" . Genomics . 28 (2): 347–349. doi :10.1006/geno.1995.1154 . PMID 8530049 . Uhlenbrock K, Huber J, Ardati A, Busch AE, Kostenis E (2003). "Fluid shear stress differentially regulates gpr3, gpr6, and gpr12 expression in human umbilical vein endothelial cells". Cellular Physiology and Biochemistry . 13 (2): 75–84. doi :10.1159/000070251 . PMID 12649592 . S2CID 45156405 .
External links [ edit ] "GPR6" . IUPHAR Database of Receptors and Ion Channels . International Union of Basic and Clinical Pharmacology. Archived from the original on 2012-09-02. Retrieved 2009-04-24 .
