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3-Methyl-GABA
Names
IUPAC name
4-Amino-3-methylbutanoic acid
Other names
  • HMS3266K11
  • HMS3411G19
Identifiers
3D model (JSmol)
ChEBI
ChEMBL
ChemSpider
  • InChI=1S/C5H11NO2/c1-4(3-6)2-5(7)8/h4H,2-3,6H2,1H3,(H,7,8)
    Key: CZGLBWZXGIAIBU-UHFFFAOYSA-N
  • CC(CC(=O)O)CN
Properties
C5H11NO2
Molar mass 117.148 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).

3-Methyl-GABA, also known as HMS3266K11, is an anticonvulsant alkaloid.

Pharmacology[edit]

3-Methyl-GABA is an activator of GABA-T, an enzyme that transforms GABA to succinate semialdehyde and glutamate.[1]

It also activates glutamate decarboxylase, an enzyme that is needed in GABA synthesis. This is thought to be the primary mechanism of action behind its anticonvulsant action.[2][3]

References[edit]

  1. ^ https://www.tocris.com/products/3-methyl-gaba_0386
  2. ^ https://www.medchemexpress.com/3-methyl-gaba.html
  3. ^ Silverman, Richard B.; Andruszkiewicz, Ryszard; Nanavati, Shrenik M.; Taylor, Charles P.; Vartanian, Mark G. (1991). "3-Alkyl-4-aminobutyric acids: The first class of anticonvulsant agents that activates L-glutamic acid decarboxylase". Journal of Medicinal Chemistry. 34 (7): 2295–2298. doi:10.1021/jm00111a053. PMID 2067001.
source: https://en.wikipedia.org/w/index.php?title=3-Methyl-GABA&action=edit&redlink=1

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