Protein-coding gene in the species Homo sapiens
Interferon-alpha/beta receptor alpha chain is a protein that in humans is encoded by the IFNAR1 gene .[ 5] [ 6]
The protein encoded by this gene is a type I membrane protein that forms one of the two chains of a receptor for type I interferons , including interferon-alpha, -beta, and -lambda. Binding and activation of the receptor stimulates Janus protein kinases , which in turn phosphorylate several proteins, including STAT1 and STAT2 . The encoded protein also functions as an antiviral factor.[ 6]
IFNAR1 has been shown to interact with:
^ a b c GRCh38: Ensembl release 89: ENSG00000142166 – Ensembl , May 2017
^ a b c GRCm38: Ensembl release 89: ENSMUSG00000022967 – Ensembl , May 2017
^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Novick D, Cohen B, Rubinstein M (Jun 1994). "The human interferon alpha/beta receptor: characterization and molecular cloning". Cell . 77 (3): 391–400. doi :10.1016/0092-8674(94)90154-6 . PMID 8181059 . S2CID 140206806 .
^ a b "Entrez Gene: IFNAR1 interferon (alpha, beta and omega) receptor 1" .
^ Abramovich C, Yakobson B, Chebath J, Revel M (Jan 1997). "A protein-arginine methyltransferase binds to the intracytoplasmic domain of the IFNAR1 chain in the type I interferon receptor" . EMBO J . 16 (2): 260–6. doi :10.1093/emboj/16.2.260 . PMC 1169633 . PMID 9029147 .
^ Li X, Leung S, Kerr IM, Stark GR (Apr 1997). "Functional subdomains of STAT2 required for preassociation with the alpha interferon receptor and for signaling" . Mol. Cell. Biol . 17 (4): 2048–56. doi :10.1128/mcb.17.4.2048 . PMC 232052 . PMID 9121453 .
^ Uddin S, Chamdin A, Platanias LC (Oct 1995). "Interaction of the transcriptional activator Stat-2 with the type I interferon receptor" . J. Biol. Chem . 270 (42): 24627–30. doi :10.1074/jbc.270.42.24627 . PMID 7559568 .
^ Yan H, Krishnan K, Greenlund AC, Gupta S, Lim JT, Schreiber RD, Schindler CW, Krolewski JJ (Mar 1996). "Phosphorylated interferon-alpha receptor 1 subunit (IFNaR1) acts as a docking site for the latent form of the 113 kDa STAT2 protein" . EMBO J . 15 (5): 1064–74. doi :10.1002/j.1460-2075.1996.tb00444.x . PMC 450004 . PMID 8605876 .
^ Richter MF, Duménil G, Uzé G, Fellous M, Pellegrini S (Sep 1998). "Specific contribution of Tyk2 JH regions to the binding and the expression of the interferon alpha/beta receptor component IFNAR1" . J. Biol. Chem . 273 (38): 24723–9. doi :10.1074/jbc.273.38.24723 . PMID 9733772 .
^ Kumar KG, Varghese B, Banerjee A, Baker DP, Constantinescu SN, Pellegrini S, Fuchs SY (Jul 2008). "Basal ubiquitin-independent internalization of interferon alpha receptor is prevented by Tyk2-mediated masking of a linear endocytic motif" . J. Biol. Chem . 283 (27): 18566–72. doi :10.1074/jbc.M800991200 . PMC 2441555 . PMID 18474601 .
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Uddin S, Chamdin A, Platanias LC (1995). "Interaction of the transcriptional activator Stat-2 with the type I interferon receptor" . J. Biol. Chem . 270 (42): 24627–30. doi :10.1074/jbc.270.42.24627 . PMID 7559568 .
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Abramovich C, Yakobson B, Chebath J, Revel M (1997). "A protein-arginine methyltransferase binds to the intracytoplasmic domain of the IFNAR1 chain in the type I interferon receptor" . EMBO J . 16 (2): 260–6. doi :10.1093/emboj/16.2.260 . PMC 1169633 . PMID 9029147 .
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Richter MF, Duménil G, Uzé G, Fellous M, Pellegrini S (1998). "Specific contribution of Tyk2 JH regions to the binding and the expression of the interferon alpha/beta receptor component IFNAR1" . J. Biol. Chem . 273 (38): 24723–9. doi :10.1074/jbc.273.38.24723 . PMID 9733772 .
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