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This article is or was the subject of a Wiki Education Foundation-supported course assignment. Further details are available on the course page. Peer reviewers: OMM93, Ovorp.

Above undated message substituted from Template:Dashboard.wikiedu.org assignment by PrimeBOT (talk) 16:40, 16 January 2022 (UTC)[reply]

Before I began editing, these pages were a jumbled mess of confused science and faux-science that had clearly been compiled by recreational marijuana users with minimal understand of how solid research is conducted or reported. Most of the sections were written independently and did not read cohesively when considered by page; as such much of my efforts were spent cleaning up the inconsistencies, miscitations, and straight up fallacies that littered each topic discussed. In addition, I added more citations from appropriate and current research and reorganized the pages so that they are presented in a more digestable format. In summary, these pages on endocannabinoid receptors were not lacking attention before my edits, but had rather received too much attention from people who just did not know what they were talking about. I have simplified, clarified, and expounded where appropriate with the intention of creating a more cohesive and through product. The extent of these edits are subtle, but were based on eight research pages that I read dealing with the topics I addressed. — Preceding unsigned comment added by Wyliea (talk • contribs) 01:45, 7 December 2011 (UTC)[reply]

It should be made clear that the 'structure' shown for CB1 is only a 9 amino acid portion of one of the peptides of the full receptor. Unfortunately, there does not appear to be a full structure of the whole receptor on the PDB, but PDB ID 2KOE (Human cannabinoid receptor 1 - helix 7/8 peptide) might be an better choice until a complete structure is published.
--Bhbuehler (talk) 03:48, 6 June 2015 (UTC) Agree, bullshit is depicted. --132.68.106.136 (talk) 16:12, 18 May 2017 (UTC) I have uploaded a picture of the structure to the commons. I'm having trouble getting on the page. Any help would be appreciated, or if you can get a better picture that'd be great too. https://commons.wikimedia.org/wiki/File:Cannabinoid_CB1_Receptor.png Jpecquex (talk) 19:24, 19 June 2017 (UTC)[reply]

Studies show CB1 mediated plasticity in Dorsal striatum, Amygdala, Prefrontal cortex, and Ventral tegmental area as well as the BNST, so this section can be updated. Here is an review by Sidpura and Parsons on the topic Cite error: A <ref> tag is missing the closing </ref> (see the help page).</ref>. I just added a sentence.

OMM93 (talk) 05:12, 1 October 2015 (UTC)[reply]

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This page has come a long way in the past few years. It is looking great right now.

No mention on the astroglial CB1 receptor? The articles bellow mention it as being associated with the working memory impairments.

• Han J, Kesner P, Metna-Laurent M, Duan T, Xu L, Georges F, Koehl M, Abrous DN, Mendizabal-Zubiaga J, Grandes P, Liu Q, Bai G, Wang W, Xiong L, Ren W (2012-03-02). "Acute Cannabinoids Impair Working Memory through Astroglial CB1 Receptor Modulation of Hippocampal LTD". Cell. 148 (5): 1039–1050. doi:10.1016/j.cell.2012.01.037. PMID 22385967.

• Noriega-Prieto JA, Kofuji P, Araque A (2022-08-08). "Endocannabinoid signaling in synaptic function". Glia. 71 (1): 36–43. doi:10.1002/glia.24256. ISSN 0894-1491. PMC 9679333. PMID 36408881.

— Arthurfragoso (talk) 04:48, 19 January 2023 (UTC)[reply]

I could not find a direct statement saying Minocycline is a CB1 agonist. At least should not be on top. 103.160.128.19 (talk) 23:49, 9 December 2023 (UTC)[reply]

Citation for the claim is this study https://academic.oup.com/cercor/article/25/1/35/365149 titled "CB1 and CB2 Cannabinoid Receptor Antagonists Prevent Minocycline-Induced Neuroprotection Following Traumatic Brain Injury in Mice" by "Ana Belen Lopez-Rodriguez, Eleni Siopi, David P. Finn, Catherine Marchand-Leroux, Luis M. Garcia-Segura, Mehrnaz Jafarian-Tehrani, Maria-Paz Viveros" published in "Cerebral Cortex, Volume 25, Issue 1, January 2015, Pages 35–45". ^[1] which would imply cannabinoid activity but agreed, this doesn't exactly mean it's an agonist Gettinglit (talk) 23:31, 12 December 2023 (UTC)[reply]

This article is currently the subject of a Wiki Education Foundation-supported course assignment, between 9 January 2024 and 26 April 2024. Further details are available on the course page. Student editor(s): Sdavis81 (article contribs). Peer reviewers: FormallyTrainedHomunculus, Whitneyatwelle, Morrisse95.

— Assignment last updated by Arianamarievasquez (talk) 04:13, 8 April 2024 (UTC)[reply]