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MRGPRD

Identifiers

MRGPRD, MRGD, TGR7, MAS related GPR family member D

External IDs

OMIM: 607231 MGI: 3033142 HomoloGene: 18893 GeneCards: MRGPRD

Gene location (Human)

Chr.	Chromosome 11 (human)^[1]

Band	11q13.3	Start	68,980,021 bp^[1]
Band	11q13.3	End	68,980,986 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 7 (mouse)^[2]

Band	7\|7 F5	Start	144,868,572 bp^[2]
Band	7\|7 F5	End	144,877,823 bp^[2]

RNA expression pattern

Human

Mouse (ortholog)

Top expressed in

Top expressed in

More reference expression data

n/a

Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo / QuickGO

Species

Human

Mouse


116512


211578


ENSG00000172938


ENSMUSG00000051207


Q8TDS7


Q91ZB8

RefSeq (mRNA)


NM_198923


NM_203490

RefSeq (protein)


NP_944605


NP_987075

Location (UCSC)

Chr 11: 68.98 – 68.98 Mb

Chr 7: 144.87 – 144.88 Mb

PubMed search

^[3]

^[4]

View/Edit Human

View/Edit Mouse

Mas-related G-protein coupled receptor member D is a protein that in humans is encoded by the MRGPRD gene.^[5]^[6]^[7]

See also[edit]

MAS1 oncogene

References[edit]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000172938 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000051207 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Dong X, Han S, Zylka MJ, Simon MI, Anderson DJ (Sep 2001). "A diverse family of GPCRs expressed in specific subsets of nociceptive sensory neurons". Cell. 106 (5): 619–32. doi:10.1016/S0092-8674(01)00483-4. PMID 11551509. S2CID 14119088.
^ Zylka MJ, Dong X, Southwell AL, Anderson DJ (Aug 2003). "Atypical expansion in mice of the sensory neuron-specific Mrg G protein-coupled receptor family". Proc Natl Acad Sci U S A. 100 (17): 10043–8. Bibcode:2003PNAS..10010043Z. doi:10.1073/pnas.1732949100. PMC 187757. PMID 12909716.
^ "Entrez Gene: MRGPRD MAS-related GPR, member D".

Further reading[edit]

Takeda S, Kadowaki S, Haga T, et al. (2002). "Identification of G protein-coupled receptor genes from the human genome sequence". FEBS Lett. 520 (1–3): 97–101. doi:10.1016/S0014-5793(02)02775-8. PMID 12044878. S2CID 7116392.
Shinohara T, Harada M, Ogi K, et al. (2004). "Identification of a G protein-coupled receptor specifically responsive to beta-alanine". J. Biol. Chem. 279 (22): 23559–64. doi:10.1074/jbc.M314240200. PMID 15037633.

Cell surface receptor: G protein-coupled receptors

Class A: Rhodopsin-like

Neurotransmitter

Adrenergic	α1 (A B D) α2 (A B C) β1 β2 β3
Purinergic	Adenosine (A1 A2A A2B A3) P2Y (1 2 4 5 6 8 9 10 11 12 13 14)
Serotonin	(all but 5-HT3) 5-HT1 (A B D E F) 5-HT2 (A B C) 5-HT (4 5A 6 7)
Other	Acetylcholine (M1 M2 M3 M4 M5) Dopamine D1 D2 D3 D4 D5 GHB receptor Histamine H1 H2 H3 H4 Melatonin (1A 1B 1C) TAAR (1 2 5 6 8 9)

Metabolites and
signaling molecules

Eicosanoid	CysLT (1 2) LTB4 1 2 FPRL1 OXE Prostaglandin DP (1 2), EP (1 2 3 4), FP Prostacyclin Thromboxane
Other	Bile acid Cannabinoid (CB1 CB2, GPR (18 55 119)) EBI2 Estrogen Free fatty acid (1 2 3 4) Hydroxycarboxylic acids 1 2 3 Lysophosphatidic acid (1 2 3 4 5 6) Lysophospholipid (1 2 3 4 5 6 7 8) Oxoglutarate PAF Sphingosine-1-phosphate (1 2 3 4 5) Succinate

Peptide

B/W (1
2)
FF (1
2)
S
Y (1
2
4
5)
Neuromedin (B
U (1
2))
Neurotensin (1
2)

Other

Miscellaneous

Taste, bitter	TAS2R 1 3 4 5 7 8 9 10 13 14 16 19 20 30 31 38 39 40 41 42 43 45 46 50 60 Vomeronasal receptor type 1
Orphan	GPR (1 3 4 6 12 15 17 18 19 20 21 22 23 25 26 27 31 32 33 34 35 37 39 42 44 45 50 52 55 61 62 63 65 68 75 78 81 82 83 84 85 87 88 92 101 103 109A 109B 119 120 132 135 137B 139 141 142 146 148 149 150 151 152 153 160 161 162 171 173 174 176 177 182 183)
Other	Adrenomedullin Olfactory Opsin (3 4 5 1LW 1MW 1SW RGR RRH) Protease-activated (1 2 3 4) SREB (1 2 3)

Class B: Secretin-like

Adhesion	ADGRB Brain-specific angiogenesis inhibitor 1 2 3 ADGRC Cadherin 1 2 3 ADGRE EMR 1 2 3 CD97 ADGRG 1 2 3 4 5 6 7 ADGRL Latrophilin 1 2 3 ELTD1
Orphan	GPR (56 64 97 98 110 111 112 113 114 115 116 123 124 125 126 128 133 143 144 155 157)
Other	Calcitonin CALCRL Corticotropin-releasing hormone (1 2) Glucagon (GR GIPR GLP1R GLP2R) Growth-hormone-releasing hormone PACAPR1 GPR Methuselah-like proteins Parathyroid hormone (1 2) Secretin Vasoactive intestinal peptide (1 2)

Class C: Metabotropic glutamate / pheromone

Taste, sweet	TAS1R 1 2 3 Vomeronasal receptor, type 2
Other	Calcium-sensing receptor GABA_B (1 2) Glutamate receptor (Metabotropic glutamate (1 2 3 4 5 6 7 8)) GPRC6A GPR (156 158 179) RAIG (1 2 3 4)

Class F: Frizzled & Smoothened

Frizzled	Frizzled (1 2 3 4 5 6 7 8 9 10)
Smoothened	Smoothened

source: https://en.wikipedia.org/wiki/MRGPRD