This gene encodes a member of the neuroD family of neurogenic basic helix-loop-helix (bHLH) proteins. Expression of this gene can induce transcription from neuron-specific promoters, such as the GAP-43 promoter, which contain a specific DNA sequence known as an E-box. The product of the human gene can induce neurogenic differentiation in non-neuronal cells in Xenopus embryos, and is thought to play a role in the determination and maintenance of neuronal cell fates.[6]
Kume H, Maruyama K, Shinozaki K, Kuzume H, Obata K (Sep 1998). "Phosphorylation and spatiotemporal distribution of KW8 (NDRF/NeuroD2), a NeuroD family basic helix-loop-helix protein". Brain Research. Molecular Brain Research. 60 (1): 107–14. doi:10.1016/S0169-328X(98)00176-4. PMID9748526.
Kitamura T, Miyachi T, Nakamura S, Kawakami H (Apr 1999). "Identification and analysis of the promoter region of the human NeuroD-related factor (NDRF)1". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1445 (1): 142–7. doi:10.1016/s0167-4781(99)00038-x. PMID10209266.
Shibata H, Oda H, Mukai H, Oishi K, Misaki K, Ohkubo H, Ono Y (Dec 1999). "Interaction of PKN with a neuron-specific basic helix-loop-helix transcription factor, NDRF/NeuroD2". Brain Research. Molecular Brain Research. 74 (1–2): 126–34. doi:10.1016/S0169-328X(99)00273-9. PMID10640683.
Cousin P, Billotte J, Chaubert P, Shaw P (Jan 2000). "Physical map of 17p13 and the genes adjacent to p53". Genomics. 63 (1): 60–8. doi:10.1006/geno.1999.6062. PMID10662545.
Franklin A, Kao A, Tapscott S, Unis A (Nov 2001). "NeuroD homologue expression during cortical development in the human brain". Journal of Child Neurology. 16 (11): 849–53. doi:10.1177/08830738010160111201. PMID11732772. S2CID20069074.
Westerman BA, Poutsma A, Maruyama K, Schrijnemakers HF, van Wijk IJ, Oudejans CB (Apr 2002). "The proneural genes NEUROD1 and NEUROD2 are expressed during human trophoblast invasion". Mechanisms of Development. 113 (1): 85–90. doi:10.1016/S0925-4773(01)00665-7. PMID11900979. S2CID11607202.
Westerman BA, Chhatta A, Poutsma A, van Vegchel T, Oudejans CB (Jan 2004). "NEUROD1 acts in vitro as an upstream regulator of NEUROD2 in trophoblast cells". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1676 (1): 96–103. doi:10.1016/j.bbaexp.2003.10.002. PMID14732494.
Zill P, Büttner A, Eisenmenger W, Bondy B (Jun 2006). "A possible impact of the neuroD2 transcription factor on the development of drug abusing behavior". Molecular Psychiatry. 11 (6): 525–7. doi:10.1038/sj.mp.4001825. PMID16607387. S2CID7713810.
