Protein-coding gene in the species Homo sapiens
L-myc-1 proto-oncogene protein is a protein that in humans is encoded by the MYCL1 gene .[5] [6]
MYCL1 is a bHLH (basic helix-loop-helix) transcription factor implicated in lung cancer.[7]
Interactions [ edit ] MYCL1 has been shown to interact with MAX .[8] [9]
References [ edit ]
^ a b c GRCh38: Ensembl release 89: ENSG00000116990 - Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028654 - Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Speleman F, Van Camp G, Van Roy N (Jan 1997). "Reassignment of MYCL1 to human chromosome 1p34.3 by fluorescence in situ hybridization". Cytogenet Cell Genet . 72 (2–3): 189–190. doi :10.1159/000134185 . PMID 8978772 . ^ "Entrez Gene: MYCL1 v-myc myelocytomatosis viral oncogene homolog 1, lung carcinoma derived (avian)" .^ Ikegaki N, Minna J, Kennett RH (1989). "The human L-myc gene is expressed as two forms of protein in small cell lung carcinoma cell lines: detection by monoclonal antibodies specific to two myc homology box sequences" . EMBO J . 8 (6): 1793–9. doi :10.1002/j.1460-2075.1989.tb03573.x . PMC 401025 PMID 2548855 . ^ Blackwood EM, Eisenman RN (Mar 1991). "Max: a helix-loop-helix zipper protein that forms a sequence-specific DNA-binding complex with Myc". Science 251 (4998): 1211–1217. Bibcode :1991Sci...251.1211B . doi :10.1126/science.2006410 . PMID 2006410 . ^ FitzGerald MJ, Arsura M, Bellas RE, Yang W, Wu M, Chin L, Mann KK, DePinho RA, Sonenshein GE (Apr 1999). "Differential effects of the widely expressed dMax splice variant of Max on E-box vs initiator element-mediated regulation by c-Myc" . Oncogene . 18 (15): 2489–2498. doi :10.1038/sj.onc.1202611 PMID 10229200 .
Further reading [ edit ]
Lüscher B (2001). "Function and regulation of the transcription factors of the Myc/Max/Mad network". Gene . 277 (1–2): 1–14. doi :10.1016/S0378-1119(01)00697-7 . PMID 11602341 . Ikegaki N, Minna J, Kennett RH (1989). "The human L-myc gene is expressed as two forms of protein in small cell lung carcinoma cell lines: detection by monoclonal antibodies specific to two myc homology box sequences" . EMBO J . 8 (6): 1793–9. doi :10.1002/j.1460-2075.1989.tb03573.x . PMC 401025 PMID 2548855 . Kaye F, Battey J, Nau M, Brooks B, Seifter E, De Greve J, Birrer M, Sausville E, Minna J (1988). "Structure and expression of the human L-myc gene reveal a complex pattern of alternative mRNA processing" . Mol. Cell. Biol . 8 (1): 186–95. doi :10.1128/mcb.8.1.186 . PMC 363100 PMID 2827002 . De Greve J, Battey J, Fedorko J, Birrer M, Evan G, Kaye F, Sausville E, Minna J (1988). "The human L-myc gene encodes multiple nuclear phosphoproteins from alternatively processed mRNAs" . Mol. Cell. Biol . 8 (10): 4381–8. doi :10.1128/mcb.8.10.4381 . PMC 365511 PMID 3054516 . DePinho RA, Hatton KS, Tesfaye A, Yancopoulos GD, Alt FW (1988). "The human myc gene family: structure and activity of L-myc and an L-myc pseudogene" . Genes Dev . 1 (10): 1311–1326. doi :10.1101/gad.1.10.1311 PMID 3322939 . Atchley WR, Fitch WM (1995). "Myc and Max: molecular evolution of a family of proto-oncogene products and their dimerization partner" . Proc. Natl. Acad. Sci. U.S.A . 92 (22): 10217–10221. Bibcode :1995PNAS...9210217A . doi :10.1073/pnas.92.22.10217 PMC 40767 PMID 7479755 . FitzGerald MJ, Arsura M, Bellas RE, Yang W, Wu M, Chin L, Mann KK, DePinho RA, Sonenshein GE (1999). "Differential effects of the widely expressed dMax splice variant of Max on E-box vs initiator element-mediated regulation by c-Myc" . Oncogene . 18 (15): 2489–2498. doi :10.1038/sj.onc.1202611 PMID 10229200 . Kumimoto H, Hamajima N, Nishimoto Y, Matsuo K, Shinoda M, Hatooka S, Ishizaki K (2002). "L-myc genotype is associated with different susceptibility to lung cancer in smokers" . Jpn. J. Cancer Res . 93 (1): 1–5. doi :10.1111/j.1349-7006.2002.tb01193.x . PMC 5926866 PMID 11802801 . Suzuki H, Yamashiro K (2002). "L-myc restriction fragment length polymorphism and histological pattern of invasion in lung adenocarcinoma". Oncol. Rep . 9 (2): 345–7. doi :10.3892/or.9.2.345 . PMID 11836605 . Primdahl H, von der Maase H, Christensen M, Wolf H, Ørntoft TF (2002). "Allelic deletions of Rb and L-myc in urine sediments from patients with bladder tumors or carcinoma in situ". Oncol. Rep . 9 (3): 551–5. doi :10.3892/or.9.3.551 . PMID 11956626 . Demopoulos K, Arvanitis DA, Vassilakis DA, Siafakas NM, Spandidos DA (2003). "MYCL1, FHIT, SPARC, p16(INK4) and TP53 genes associated to lung cancer in idiopathic pulmonary fibrosis" . J. Cell. Mol. Med . 6 (2): 215–222. doi :10.1111/j.1582-4934.2002.tb00188.x . PMC 6740283 PMID 12169206 . Wu R, Lin L, Beer DG, Ellenson LH, Lamb BJ, Rouillard JM, Kuick R, Hanash S, Schwartz DR, Fearon ER, Cho KR (2003). "Amplification and overexpression of the L-MYC proto-oncogene in ovarian carcinomas" . Am. J. Pathol . 162 (5): 1603–10. doi :10.1016/S0002-9440(10)64294-0 . PMC 1851191 PMID 12707044 . Kambara T, Sharp GB, Nagasaka T, Takeda M, Sasamoto H, Nakagawa H, Isozaki H, MacPhee DG, Jass JR, Tanaka N, Matsubara N (2004). "Allelic loss of a common microsatellite marker MYCL1: a useful prognostic factor of poor outcomes in colorectal cancer" . Clin. Cancer Res . 10 (5): 1758–1763. doi :10.1158/1078-0432.CCR-0779-3 PMID 15014029 . Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY , Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature . 437 (7062): 1173–1178. Bibcode :2005Natur.437.1173R . doi :10.1038/nature04209 . PMID 16189514 . S2CID 4427026 . Spinola M, Falvella FS, Galvan A, Pignatiello C, Leoni VP, Pastorino U, Paroni R, Chen S, Skaug V, Haugen A, Dragani TA (2007). "Ethnic differences in frequencies of gene polymorphisms in the MYCL1 region and modulation of lung cancer patients' survival" (PDF) . Lung Cancer . 55 (3): 271–277. doi :10.1016/j.lungcan.2006.10.023 . hdl :2434/25016 PMID 17145094 .
External links [ edit ] This article incorporates text from the United States National Library of Medicine , which is in the public domain .
(1) Basic domains
(1.1) Basic leucine zipper (bZIP )(1.2) Basic helix-loop-helix (bHLH )
Group A Group B Group CPAS Group D Group E Group F
(1.3) bHLH-ZIP (1.4) NF-1 (1.5) RF-X (1.6) Basic helix-span-helix (bHSH)
(2) Zinc finger DNA-binding domains
(2.1) Nuclear receptor (Cys4 )
subfamily 1 subfamily 2 subfamily 3 subfamily 4 subfamily 5 subfamily 6 subfamily 0
(2.2) Other Cys4 (2.3) Cys2 His2 (2.4) Cys6 (2.5) Alternating composition (2.6) WRKY
(4) β-Scaffold factors with minor groove contacts
(0) Other transcription factors
