Protein-coding gene in the species Homo sapiens
CCAAT/enhancer binding protein (C/EBP), epsilon , also known as CEBPE and CRP1 , is a type of ccaat-enhancer-binding protein . CEBPE is its human gene [5] [6] apoptotic .[7]
The protein encoded by this gene is a bZIP transcription factor which can bind as a homodimer to certain DNA regulatory regions. It can also form heterodimers with the related protein CEBP-δ . The encoded protein may be essential for terminal differentiation and functional maturation of committed granulocyte progenitor cells . Mutations in this gene have been associated with specific granule deficiency , a rare congenital disorder. Multiple variants of this gene have been described, but the full-length nature of only one has been determined.[5]
References [ edit ]
^ a b c GRCh38: Ensembl release 89: ENSG00000092067 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000052435 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ a b "Entrez Gene: CEBPE CCAAT/enhancer binding protein (C/EBP), epsilon" .^ Antonson P, Stellan B, Yamanaka R, Xanthopoulos KG (Jul 1996). "A novel human CCAAT/enhancer binding protein gene, C/EBPepsilon, is expressed in cells of lymphoid and myeloid lineages and is localized on chromosome 14q11.2 close to the T-cell receptor alpha/delta locus". Genomics . 35 (1): 30–8. doi :10.1006/geno.1996.0319 . PMID 8661101 . ^ Nakajima H, Watanabe N, Shibata F, Kitamura T, Ikeda Y, Handa M (May 2006). "N-terminal region of CCAAT/enhancer-binding protein epsilon is critical for cell cycle arrest, apoptosis, and functional maturation during myeloid differentiation" . The Journal of Biological Chemistry . 281 (20): 14494–502. doi :10.1074/jbc.M600575200 PMID 16531405 .
Further reading [ edit ]
Sladek FM, Darnell JE (Apr 1992). "Mechanisms of liver-specific gene expression". Current Opinion in Genetics & Development . 2 (2): 256–9. doi :10.1016/S0959-437X(05)80282-5 . PMID 1638120 . Gombart AF, Koeffler HP (Jan 2002). "Neutrophil specific granule deficiency and mutations in the gene encoding transcription factor C/EBP(epsilon)". Current Opinion in Hematology . 9 (1): 36–42. doi :10.1097/00062752-200201000-00007 . PMID 11753076 . S2CID 25411864 . Williams SC, Cantwell CA, Johnson PF (Sep 1991). "A family of C/EBP-related proteins capable of forming covalently linked leucine zipper dimers in vitro" . Genes & Development . 5 (9): 1553–67. doi :10.1101/gad.5.9.1553 PMID 1884998 . Antonson P, Stellan B, Yamanaka R, Xanthopoulos KG (Jul 1996). "A novel human CCAAT/enhancer binding protein gene, C/EBPepsilon, is expressed in cells of lymphoid and myeloid lineages and is localized on chromosome 14q11.2 close to the T-cell receptor alpha/delta locus". Genomics . 35 (1): 30–8. doi :10.1006/geno.1996.0319 . PMID 8661101 . Chumakov AM, Grillier I, Chumakova E, Chih D, Slater J, Koeffler HP (Mar 1997). "Cloning of the novel human myeloid-cell-specific C/EBP-epsilon transcription factor" . Molecular and Cellular Biology . 17 (3): 1375–86. doi :10.1128/mcb.17.3.1375 . PMC 231862 PMID 9032264 . Yamanaka R, Kim GD, Radomska HS, Lekstrom-Himes J, Smith LT, Antonson P, Tenen DG, Xanthopoulos KG (Jun 1997). "CCAAT/enhancer binding protein epsilon is preferentially up-regulated during granulocytic differentiation and its functional versatility is determined by alternative use of promoters and differential splicing" . Proceedings of the National Academy of Sciences of the United States of America . 94 (12): 6462–7. doi :10.1073/pnas.94.12.6462 PMC 21072 PMID 9177240 . Verbeek W, Gombart AF, Chumakov AM, Müller C, Friedman AD, Koeffler HP (May 1999). "C/EBPepsilon directly interacts with the DNA binding domain of c-myb and cooperatively activates transcription of myeloid promoters" . Blood . 93 (10): 3327–37. doi :10.1182/blood.V93.10.3327 PMID 10233885 . Lekstrom-Himes JA, Dorman SE, Kopar P, Holland SM, Gallin JI (Jun 1999). "Neutrophil-specific granule deficiency results from a novel mutation with loss of function of the transcription factor CCAAT/enhancer binding protein epsilon" . The Journal of Experimental Medicine . 189 (11): 1847–52. doi :10.1084/jem.189.11.1847 . PMC 2193089 PMID 10359588 . Tavor S, Vuong PT, Park DJ, Gombart AF, Cohen AH, Koeffler HP (Mar 2002). "Macrophage functional maturation and cytokine production are impaired in C/EBP epsilon-deficient mice" . Blood . 99 (5): 1794–801. doi :10.1182/blood.V99.5.1794 PMID 11861297 . Zhang P, Nelson E, Radomska HS, Iwasaki-Arai J, Akashi K, Friedman AD, Tenen DG (Jun 2002). "Induction of granulocytic differentiation by 2 pathways" . Blood . 99 (12): 4406–12. doi :10.1182/blood.V99.12.4406 PMID 12036869 . Kim J, Cantwell CA, Johnson PF, Pfarr CM, Williams SC (Oct 2002). "Transcriptional activity of CCAAT/enhancer-binding proteins is controlled by a conserved inhibitory domain that is a target for sumoylation" . The Journal of Biological Chemistry . 277 (41): 38037–44. doi :10.1074/jbc.M207235200 PMID 12161447 . Du J, Stankiewicz MJ, Liu Y, Xi Q, Schmitz JE, Lekstrom-Himes JA, Ackerman SJ (Nov 2002). "Novel combinatorial interactions of GATA-1, PU.1, and C/EBPepsilon isoforms regulate transcription of the gene encoding eosinophil granule major basic protein" . The Journal of Biological Chemistry . 277 (45): 43481–94. doi :10.1074/jbc.M204777200 PMID 12202480 . Truong BT, Lee YJ, Lodie TA, Park DJ, Perrotti D, Watanabe N, Koeffler HP, Nakajima H, Tenen DG, Kogan SC (Feb 2003). "CCAAT/Enhancer binding proteins repress the leukemic phenotype of acute myeloid leukemia". Blood . 101 (3): 1141–8. doi :10.1182/blood-2002-05-1374 . PMID 12393450 . Gombart AF, Kwok SH, Anderson KL, Yamaguchi Y, Torbett BE, Koeffler HP (Apr 2003). "Regulation of neutrophil and eosinophil secondary granule gene expression by transcription factors C/EBP epsilon and PU.1" . Blood . 101 (8): 3265–73. doi :10.1182/blood-2002-04-1039 PMID 12515729 . Khanna-Gupta A, Zibello T, Sun H, Gaines P, Berliner N (May 2003). "Chromatin immunoprecipitation (ChIP) studies indicate a role for CCAAT enhancer binding proteins alpha and epsilon (C/EBP alpha and C/EBP epsilon ) and CDP/cut in myeloid maturation-induced lactoferrin gene expression" . Blood . 101 (9): 3460–8. doi :10.1182/blood-2002-09-2767 PMID 12522000 . Gery S, Gombart AF, Fung YK, Koeffler HP (Feb 2004). "C/EBPepsilon interacts with retinoblastoma and E2F1 during granulopoiesis". Blood . 103 (3): 828–35. doi :10.1182/blood-2003-01-0159 . PMID 12947005 . Gery S, Park DJ, Vuong PT, Chih DY, Lemp N, Koeffler HP (Dec 2004). "Retinoic acid regulates C/EBP homologous protein expression (CHOP), which negatively regulates myeloid target genes" . Blood . 104 (13): 3911–7. doi :10.1182/blood-2003-10-3688 PMID 15308577 .
External links [ edit ] This article incorporates text from the United States National Library of Medicine , which is in the public domain .
(1) Basic domains
(1.1) Basic leucine zipper (bZIP )(1.2) Basic helix-loop-helix (bHLH )
Group A Group B Group CPAS Group D Group E Group F
(1.3) bHLH-ZIP (1.4) NF-1 (1.5) RF-X (1.6) Basic helix-span-helix (bHSH)
(2) Zinc finger DNA-binding domains
(2.1) Nuclear receptor (Cys4 )
subfamily 1 subfamily 2 subfamily 3 subfamily 4 subfamily 5 subfamily 6 subfamily 0
(2.2) Other Cys4 (2.3) Cys2 His2 (2.4) Cys6 (2.5) Alternating composition (2.6) WRKY
(4) β-Scaffold factors with minor groove contacts
(0) Other transcription factors
