THC Science

SERPINA3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1AS4, 1QMN, 2ACH, 3CAA, 3DLW, 4CAA
Identifiers
Aliases	SERPINA3, AACT, ACT, GIG24, GIG25, serpin family A member 3
External IDs	OMIM: 107280 MGI: 98377 HomoloGene: 111129 GeneCards: SERPINA3
Gene location (Human)
Chr.	Chromosome 14 (human)
End	94,624,055 bp
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)
End	104,312,403 bp
RNA expression pattern
	Top expressed in
	Top expressed in
	More reference expression data
	More reference expression data
Gene ontology
Molecular function
Cellular component
Biological process
	Sources:Amigo / QuickGO
Orthologs
	12
	20714
	ENSG00000196136
	ENSMUSG00000058207
	P01011
	P07759
	NM_001085
	NM_011458
	NP_001076
	NP_035588
	Wikidata
View/Edit Human	View/Edit Mouse

Alpha 1-antichymotrypsin (symbol α₁AC,^[5] A1AC, or a1ACT) is an alpha globulin glycoprotein that is a member of the serpin superfamily. In humans, it is encoded by the SERPINA3 gene.

Function[edit]

Alpha 1-antichymotrypsin inhibits the activity of certain enzymes called proteases, such as cathepsin G that is found in neutrophils, and chymases found in mast cells, by cleaving them into a different shape or conformation. This activity protects some tissues, such as the lower respiratory tract, from damage caused by proteolytic enzymes.^[6]

This protein is produced in the liver, and is an acute phase protein that is induced during inflammation.

Clinical significance[edit]

Deficiency of this protein has been associated with liver disease. Mutations have been identified in patients with Parkinson disease and chronic obstructive pulmonary disease.^[7]

Alpha 1-antichymotrypsin is also associated with the pathogenesis of Alzheimer's disease as it enhances the formation of amyloid-fibrils in this disease.^[6]

Interactions[edit]

Alpha 1-antichymotrypsin has been shown to interact with DNAJC1.^[8]

References[edit]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000196136 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000058207 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Logan, Carolynn M.; Rice, M. Katherine (1987). Logan's Medical and Scientific Abbreviations. Philadelphia: J. B. Lippincott Company. p. 3. ISBN 0-397-54589-4.
^ ^a ^b Kalsheker N (1996). "Alpha 1-antichymotrypsin". Int. J. Biochem. Cell Biol. 28 (9): 961–4. doi:10.1016/1357-2725(96)00032-5. PMID 8930118. S2CID 11230631.
^ "Entrez Gene: SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3".
^ Kroczynska B, Evangelista CM, Samant SS, Elguindi EC, Blond SY (March 2004). "The SANT2 domain of the murine tumor cell DnaJ-like protein 1 human homologue interacts with alpha1-antichymotrypsin and kinetically interferes with its serpin inhibitory activity". J. Biol. Chem. 279 (12): 11432–43. doi:10.1074/jbc.M310903200. PMC 1553221. PMID 14668352.

External links[edit]

The MEROPS online database for peptidases and their inhibitors: I04.002
Alpha+1-antichymotrypsin at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
Human SERPINA3 genome location and SERPINA3 gene details page in the UCSC Genome Browser.
Overview of all the structural information available in the PDB for UniProt: P01011 (Human Alpha-1-antichymotrypsin) at the PDBe-KB.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000196136 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000058207 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[loganabbrev-5] Logan, Carolynn M.; Rice, M. Katherine (1987). Logan's Medical and Scientific Abbreviations. Philadelphia: J. B. Lippincott Company. p. 3. ISBN 0-397-54589-4.

[kalsheker-6] Kalsheker N (1996). "Alpha 1-antichymotrypsin". Int. J. Biochem. Cell Biol. 28 (9): 961–4. doi:10.1016/1357-2725(96)00032-5. PMID 8930118. S2CID 11230631.

[7] "Entrez Gene: SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3".

[pmid14668352-8] Kroczynska B, Evangelista CM, Samant SS, Elguindi EC, Blond SY (March 2004). "The SANT2 domain of the murine tumor cell DnaJ-like protein 1 human homologue interacts with alpha1-antichymotrypsin and kinetically interferes with its serpin inhibitory activity". J. Biol. Chem. 279 (12): 11432–43. doi:10.1074/jbc.M310903200. PMC 1553221. PMID 14668352.

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Serpins
inhibitory	Alpha 1-antichymotrypsin Alpha 1-antitrypsin Alpha 2-antiplasmin Antithrombin C1-inhibitor Heparin cofactor II Protein C inhibitor Plasminogen activator inhibitor-1 Plasminogen activator inhibitor-2 Protein Z-related protease inhibitor SERPINA1 SERPINA2 SERPINA3 SERPINA4 SERPINA5 SERPINA9 SERPINA14 SERPINB1 SERPINB2 SERPINB3 SERPINB4 SERPINB5 SERPINB6 SERPINB7 SERPINB8 SERPINB9 SERPINB10 SERPINB13 SERPINC1 SERPIND1 SERPINE1 SERPINE2 SERPINE2 SERPINF1 SERPING1 SERPINH1 SERPINI1 SERPINI2
Cross class inhibitory	MENT SCCA-1 CrmA
noninhibitory	Heat shock protein 47 Maspin Ovalbumin Transcortin Thyroxine-binding globulin Angiotensinogen PEDF
see also disorders of globin and globulin proteins

Acute-phase proteins
Amyloid	SAP SAA
Other positive	Alpha 1-antichymotrypsin Alpha 1-antitrypsin Alpha 2-macroglobulin C-reactive protein Ceruloplasmin C3 Ferritin Fibrin Haptoglobin Haptoglobin-related protein Hemopexin Orosomucoid
Negative	Serum albumin Transferrin

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Function[edit]

Clinical significance[edit]

Interactions[edit]

See also[edit]

References[edit]

Further reading[edit]

External links[edit]

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