THC Science

Prorenoic acid
Clinical data
Other names	Prorenoate; 6α,7α-Dihydro-17-hydroxy-3-oxo-3'H-cyclopropa(6,7)-17α-pregna-4,6-diene-21-carboxylic acid
Drug class	Antimineralocorticoid
Identifiers
	IUPAC name 3-[(1R,2R,4R,10R,11S,14S,15R,18S)-15-Hydroxy-10,14-dimethyl-7-oxopentacyclo[9.7.0.02,4.05,10.014,18]octadec-5-en-15-yl]propanoate;
CAS Number	49848-01-3 ;
UNII	WET36J3301;
Chemical and physical data
Formula	C23H31O4
Molar mass	371.497 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O([H])[C@](CCC(=O)[O-])1CC[C@@]([H])2[C@]1(C)CC[C@@]([H])1[C@](C)3CCC(C=C3[C@@]([H])3C[C@]3([H])[C@@]21[H])=O;
	InChI InChI=1S/C23H32O4/c1-21-7-3-13(24)11-18(21)14-12-15(14)20-16(21)4-8-22(2)17(20)5-9-23(22,27)10-6-19(25)26/h11,14-17,20,27H,3-10,12H2,1-2H3,(H,25,26)/p-1/t14-,15+,16+,17+,20-,21-,22+,23-/m1/s1; Key:OHZWNMVYJJTNKU-VAFIVCJBSA-M;

Prorenoic acid, or prorenoate, is a synthetic steroidal antimineralocorticoid which was never marketed.^[1]^[2]^[3]^[4]

References[edit]

^ Elks J (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 1036–. ISBN 978-1-4757-2085-3.
^ Claire M, Rafestin-Oblin ME, Michaud A, Roth-Meyer C, Corvol P (April 1979). "Mechanism of action of a new antialdosterone compound, prorenone". Endocrinology. 104 (4): 1194–1200. doi:10.1210/endo-104-4-1194. PMID 436757.
^ Netchitailo P, Delarue C, Perroteau I, Jegou S, Tonon MC, Leroux P, et al. (February 1982). "Effect of aldosterone antagonists on mineralocorticoid synthesis in vitro. Inhibition of aldosterone production by prorenoate-K". European Journal of Pharmacology. 77 (4): 243–249. doi:10.1016/0014-2999(82)90125-x. PMID 6277668.
^ Morton IK, Hall JM (6 December 2012). Concise Dictionary of Pharmacological Agents: Properties and Synonyms. Springer Science & Business Media. pp. 234–. ISBN 978-94-011-4439-1.