Cytochrome P450 4B1 is a protein that in humans is encoded by the CYP4B1gene.[5]
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. In rodents, the homologous protein has been shown to metabolize certain carcinogens; however, the specific function of the human protein has not been determined.[5]
Mouse Mutant Alleles for Cyp4b1
Marker Symbol for Mouse Gene. This symbol is assigned to the genomic locus by the MGI
Example structure of targeted conditional mutant allele for this gene
These Mutant ES Cells can be studied directly or used to generate mice with this gene knocked out. Study of these mice can shed light on the function of Cyp4b1:
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Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID9373149.
Hukkanen J, Mäntylä M, Kangas L, et al. (1998). "Expression of cytochrome P450 genes encoding enzymes active in the metabolism of tamoxifen in human uterine endometrium". Pharmacol. Toxicol. 82 (2): 93–7. doi:10.1111/j.1600-0773.1998.tb01404.x. PMID9498238.
Imaoka S, Yoneda Y, Sugimoto T, et al. (2000). "CYP4B1 is a possible risk factor for bladder cancer in humans". Biochem. Biophys. Res. Commun. 277 (3): 776–80. doi:10.1006/bbrc.2000.3740. PMID11062028.
Henne KR, Kunze KL, Zheng YM, et al. (2001). "Covalent linkage of prosthetic heme to CYP4 family P450 enzymes". Biochemistry. 40 (43): 12925–31. doi:10.1021/bi011171z. PMID11669629.
Iscan M, Klaavuniemi T, Coban T, et al. (2002). "The expression of cytochrome P450 enzymes in human breast tumours and normal breast tissue". Breast Cancer Res. Treat. 70 (1): 47–54. doi:10.1023/A:1012526406741. PMID11767004. S2CID25813919.
Lo-Guidice JM, Allorge D, Cauffiez C, et al. (2003). "Genetic polymorphism of the human cytochrome P450 CYP4B1: evidence for a non-functional allelic variant". Pharmacogenetics. 12 (5): 367–74. doi:10.1097/00008571-200207000-00004. PMID12142726.
