Protein-coding gene in the species Homo sapiens
WW domain-binding protein 4 is a protein that in humans is encoded by the WBP4 gene .[5] [6]
This gene encodes WW domain -containing binding protein 4. The WW domain represents a small and compact globular structure that interacts with proline-rich ligands . This encoded protein is a general spliceosomal protein that may play a role in cross-intron bridging of U1 and U2 snRNPs in the spliceosomal complex A.[6]
References [ edit ] Further reading [ edit ]
Takahara T, Tasic B, Maniatis T, et al. (2005). "Delay in synthesis of the 3' splice site promotes trans-splicing of the preceding 5' splice site" . Mol. Cell . 18 (2): 245–51. doi :10.1016/j.molcel.2005.03.018 PMID 15837427 . Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7. doi :10.1101/gr.2596504 . PMC 528928 PMID 15489334 . Dunham A, Matthews LH, Burton J, et al. (2004). "The DNA sequence and analysis of human chromosome 13" . Nature . 428 (6982): 522–8. Bibcode :2004Natur.428..522D . doi :10.1038/nature02379 . PMC 2665288 PMID 15057823 . Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs" . Nat. Genet . 36 (1): 40–5. doi :10.1038/ng1285 PMID 14702039 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Bedford MT, Frankel A, Yaffe MB, et al. (2000). "Arginine methylation inhibits the binding of proline-rich ligands to Src homology 3, but not WW, domains" . J. Biol. Chem . 275 (21): 16030–6. doi :10.1074/jbc.M909368199 PMID 10748127 . Chan DC, Bedford MT, Leder P (1996). "Formin binding proteins bear WWP/WW domains that bind proline-rich peptides and functionally resemble SH3 domains" . EMBO J . 15 (5): 1045–54. doi :10.1002/j.1460-2075.1996.tb00442.x . PMC 450002 PMID 8605874 .
