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MCOLN2
Identifiers
Aliases	MCOLN2, TRP-ML2, TRPML2, mucolipin 2, mucolipin TRP cation channel 2
External IDs	OMIM: 607399 MGI: 1915529 HomoloGene: 12258 GeneCards: MCOLN2
Gene location (Human)
Chr.	Chromosome 1 (human)
End	84,997,113 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	145,901,268 bp
RNA expression pattern
	Top expressed in
	Top expressed in
	More reference expression data
	n/a
Gene ontology
Molecular function
Cellular component
Biological process
	Sources:Amigo / QuickGO
Orthologs
	255231
	68279
	ENSG00000153898
	ENSMUSG00000011008
	Q8IZK6
	Q8K595
	NM_153259; NM_001330647
	NM_001005846; NM_026656
	NP_001317576; NP_694991
	NP_001005846; NP_080932
	Wikidata
View/Edit Human	View/Edit Mouse

Mucolipin-2 also known as TRPML2 (transient receptor potential cation channel, mucolipin subfamily, member 2) is a protein that in humans is encoded by the MCOLN2 gene.^[5] It is a member of the small family of the TRPML channels, a subgroup of the large protein family of TRP ion channels.

TRPML2 is associated with the Arf6-regulated trafficking pathway and is involved in the intracellular transport of membranes and membrane proteins.^[6]

References[edit]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000153898 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000011008 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Clapham DE, Julius D, Montell C, Schultz G (December 2005). "International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels". Pharmacol. Rev. 57 (4): 427–50. doi:10.1124/pr.57.4.6. PMID 16382100. S2CID 17936350.
^ Karacsonyi C, Miguel AS, Puertollano R (October 2007). "Mucolipin-2 localizes to the Arf6-associated pathway and regulates recycling of GPI-APs". Traffic. 8 (10): 1404–14. doi:10.1111/j.1600-0854.2007.00619.x. PMID 17662026. S2CID 25624298.

External links[edit]

MCOLN2+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000153898 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000011008 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid16382100-5] Clapham DE, Julius D, Montell C, Schultz G (December 2005). "International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels". Pharmacol. Rev. 57 (4): 427–50. doi:10.1124/pr.57.4.6. PMID 16382100. S2CID 17936350.

[pmid17662026-6] Karacsonyi C, Miguel AS, Puertollano R (October 2007). "Mucolipin-2 localizes to the Arf6-associated pathway and regulates recycling of GPI-APs". Traffic. 8 (10): 1404–14. doi:10.1111/j.1600-0854.2007.00619.x. PMID 17662026. S2CID 25624298.

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