Protein-coding gene in the species Homo sapiens
Na(+)/H(+) exchange regulatory cofactor NHE-RF3 is a protein that in humans is encoded by the PDZK1 gene .[5] [6]
Interactions [ edit ] PDZK1 has been shown to interact with:
Related gene problems [ edit ] References [ edit ]
^ a b c GRCh38: Ensembl release 89: ENSG00000174827 - Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000038298 - Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Kocher O, Comella N, Tognazzi K, Brown LF (March 1998). "Identification and partial characterization of PDZK1: a novel protein containing PDZ interaction domains". Lab Invest . 78 (1): 117–25. PMID 9461128 . ^ "Entrez Gene: PDZK1 PDZ domain containing 1" .^ a b c d e f g h Gisler SM, Pribanic S, Bacic D, Forrer P, Gantenbein A, Sabourin LA, Tsuji A, Zhao ZS, Manser E, Biber J, Murer H (November 2003). "PDZK1: I. a major scaffolder in brush borders of proximal tubular cells" . Kidney Int . 64 (5): 1733–45. doi :10.1046/j.1523-1755.2003.00266.x PMID 14531806 . ^ a b Gentzsch M, Cui L, Mengos A, Chang XB, Chen JH, Riordan JR (February 2003). "The PDZ-binding chloride channel ClC-3B localizes to the Golgi and associates with cystic fibrosis transmembrane conductance regulator-interacting PDZ proteins" . J. Biol. Chem . 278 (8): 6440–9. doi :10.1074/jbc.M211050200 PMID 12471024 . ^ Wang S, Yue H, Derin RB, Guggino WB, Li M (September 2000). "Accessory protein facilitated CFTR-CFTR interaction, a molecular mechanism to potentiate the chloride channel activity" . Cell . 103 (1): 169–79. doi :10.1016/s0092-8674(00)00096-9 PMID 11051556 . S2CID 16697781 . ^ Pribanic S, Gisler SM, Bacic D, Madjdpour C, Hernando N, Sorribas V, Gantenbein A, Biber J, Murer H (October 2003). "Interactions of MAP17 with the NaPi-IIa/PDZK1 protein complex in renal proximal tubular cells". Am. J. Physiol. Renal Physiol . 285 (4): F784-91. doi :10.1152/ajprenal.00109.2003 . PMID 12837682 . S2CID 25450845 . ^ Silver DL, Wang N, Vogel S (August 2003). "Identification of small PDZK1-associated protein, DD96/MAP17, as a regulator of PDZK1 and plasma high density lipoprotein levels" . J. Biol. Chem . 278 (31): 28528–32. doi :10.1074/jbc.M304109200 PMID 12754212 . ^ Klopocki E, Schulze H, Strauss G, Ott CE, Hall J, Trotier F, Fleischhauer S, Greenhalgh L, Newbury-Ecob RA, Neumann LM, Habenicht R, König R, Seemanova E, Megarbane A, Ropers HH, Ullmann R, Horn D, Mundlos S (February 2007). "Complex Inheritance Pattern Resembling Autosomal Recessive Inheritance Involving a Microdeletion in Thrombocytopenia–Absent Radius Syndrome" . Am. J. Hum. Genet . 80 (2): 232–40. doi :10.1086/510919 . PMC 1785342 PMID 17236129 .
Further reading [ edit ]
White KE, Biber J, Murer H, Econs MJ (1999). "A PDZ domain-containing protein with homology to Diphor-1 maps to human chromosome 1q21" . Ann. Hum. Genet . 62 (Pt 4): 287–90. doi :10.1046/j.1469-1809.1998.6240287.x PMID 9924606 . Kocher O, Comella N, Gilchrist A, Pal R, Tognazzi K, Brown LF, Knoll JH (1999). "PDZK1, a novel PDZ domain-containing protein up-regulated in carcinomas and mapped to chromosome 1q21, interacts with cMOAT (MRP2), the multidrug resistance-associated protein". Lab. Invest . 79 (9): 1161–70. PMID 10496535 . Ikemoto M, Arai H, Feng D, Tanaka K, Aoki J, Dohmae N, Takio K, Adachi H, Tsujimoto M, Inoue K (2000). "Identification of a PDZ-domain-containing protein that interacts with the scavenger receptor class B type I" . Proc. Natl. Acad. Sci. U.S.A . 97 (12): 6538–43. Bibcode :2000PNAS...97.6538I . doi :10.1073/pnas.100114397 PMC 18651 PMID 10829064 . Wang S, Yue H, Derin RB, Guggino WB, Li M (2000). "Accessory protein facilitated CFTR-CFTR interaction, a molecular mechanism to potentiate the chloride channel activity" . Cell . 103 (1): 169–79. doi :10.1016/S0092-8674(00)00096-9 PMID 11051556 . S2CID 16697781 . Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination" . Genome Res . 10 (11): 1788–95. doi :10.1101/gr.143000 . PMC 310948 PMID 11076863 . Gisler SM, Stagljar I, Traebert M, Bacic D, Biber J, Murer H (2001). "Interaction of the type IIa Na/Pi cotransporter with PDZ proteins" . J. Biol. Chem . 276 (12): 9206–13. doi :10.1074/jbc.M008745200 PMID 11099500 . Silver DL (2002). "A carboxyl-terminal PDZ-interacting domain of scavenger receptor B, type I is essential for cell surface expression in liver" . J. Biol. Chem . 277 (37): 34042–7. doi :10.1074/jbc.M206584200 PMID 12119305 . Sellin L, Huber TB, Gerke P, Quack I, Pavenstädt H, Walz G (2003). "NEPH1 defines a novel family of podocin interacting proteins" . FASEB J . 17 (1): 115–7. doi :10.1096/fj.02-0242fje PMID 12424224 . S2CID 17732086 . Gentzsch M, Cui L, Mengos A, Chang XB, Chen JH, Riordan JR (2003). "The PDZ-binding chloride channel ClC-3B localizes to the Golgi and associates with cystic fibrosis transmembrane conductance regulator-interacting PDZ proteins" . J. Biol. Chem . 278 (8): 6440–9. doi :10.1074/jbc.M211050200 PMID 12471024 . Hegedüs T, Sessler T, Scott R, Thelin W, Bakos E, Váradi A, Szabó K, Homolya L, Milgram SL, Sarkadi B (2003). "C-terminal phosphorylation of MRP2 modulates its interaction with PDZ proteins". Biochem. Biophys. Res. Commun . 302 (3): 454–61. doi :10.1016/S0006-291X(03)00196-7 . PMID 12615054 . Silver DL, Wang N, Vogel S (2003). "Identification of small PDZK1-associated protein, DD96/MAP17, as a regulator of PDZK1 and plasma high density lipoprotein levels" . J. Biol. Chem . 278 (31): 28528–32. doi :10.1074/jbc.M304109200 PMID 12754212 . Pribanic S, Gisler SM, Bacic D, Madjdpour C, Hernando N, Sorribas V, Gantenbein A, Biber J, Murer H (2003). "Interactions of MAP17 with the NaPi-IIa/PDZK1 protein complex in renal proximal tubular cells". Am. J. Physiol. Renal Physiol . 285 (4): F784–91. doi :10.1152/ajprenal.00109.2003 . PMID 12837682 . S2CID 25450845 . Gisler SM, Pribanic S, Bacic D, Forrer P, Gantenbein A, Sabourin LA, Tsuji A, Zhao ZS, Manser E, Biber J, Murer H (2004). "PDZK1: I. a major scaffolder in brush borders of proximal tubular cells" . Kidney Int . 64 (5): 1733–45. doi :10.1046/j.1523-1755.2003.00266.x PMID 14531806 . Kocher O, Yesilaltay A, Cirovic C, Pal R, Rigotti A, Krieger M (2004). "Targeted disruption of the PDZK1 gene in mice causes tissue-specific depletion of the high density lipoprotein receptor scavenger receptor class B type I and altered lipoprotein metabolism" . J. Biol. Chem . 278 (52): 52820–5. doi :10.1074/jbc.M310482200 PMID 14551195 . Inoue J, Otsuki T, Hirasawa A, Imoto I, Matsuo Y, Shimizu S, Taniwaki M, Inazawa J (2004). "Overexpression of PDZK1 within the 1q12-q22 Amplicon Is Likely To Be Associated with Drug-Resistance Phenotype in Multiple Myeloma" . Am. J. Pathol . 165 (1): 71–81. doi :10.1016/S0002-9440(10)63276-2 . PMC 1618545 PMID 15215163 . Anzai N, Miyazaki H, Noshiro R, Khamdang S, Chairoungdua A, Shin HJ, Enomoto A, Sakamoto S, Hirata T, Tomita K, Kanai Y, Endou H (2004). "The multivalent PDZ domain-containing protein PDZK1 regulates transport activity of renal urate-anion exchanger URAT1 via its C terminus" . J. Biol. Chem . 279 (44): 45942–50. doi :10.1074/jbc.M406724200 PMID 15304510 .
