Protein-coding gene in the species Homo sapiens
Platelet-derived growth factor D is a protein that in humans is encoded by the PDGFD gene .[5] [6] [7]
The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a core motif of eight cysteines, seven of which are found in this factor. This gene product only forms homodimers and, therefore, does not dimerize with the other three family members. It differs from alpha and beta members of this family in having an unusual N-terminal domain, the CUB domain . Two splice variants have been identified for this gene.[7]
References [ edit ]
^ a b c GRCh38: Ensembl release 89: ENSG00000170962 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000032006 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Hamada T, Ui-Tei K, Imaki J, Miyata Y (Feb 2001). "Molecular cloning of SCDGF-B, a novel growth factor homologous to SCDGF/PDGF-C/fallotein". Biochem Biophys Res Commun . 280 (3): 733–7. doi :10.1006/bbrc.2000.4187 . PMID 11162582 . ^ LaRochelle WJ, Jeffers M, Corvalan JR, Jia XC, Feng X, Vanegas S, Vickroy JD, Yang XD, Chen F, Gazit G, Mayotte J, Macaluso J, Rittman B, Wu F, Dhanabal M, Herrmann J, Lichenstein HS (Apr 2002). "Platelet-derived growth factor D: tumorigenicity in mice and dysregulated expression in human cancer". Cancer Res . 62 (9): 2468–73. PMID 11980634 . ^ a b "Entrez Gene: PDGFD platelet derived growth factor D" .
Further reading [ edit ]
Bergsten E, Uutela M, Li X, et al. (2001). "PDGF-D is a specific, protease-activated ligand for the PDGF beta-receptor". Nat. Cell Biol . 3 (5): 512–6. doi :10.1038/35074588 . PMID 11331881 . S2CID 25074372 . LaRochelle WJ, Jeffers M, McDonald WF, et al. (2001). "PDGF-D, a new protease-activated growth factor". Nat. Cell Biol . 3 (5): 517–21. doi :10.1038/35074593 . PMID 11331882 . S2CID 19633551 . Uutela M, Laurén J, Bergsten E, et al. (2001). "Chromosomal location, exon structure, and vascular expression patterns of the human PDGFC and PDGFC genes" . Circulation . 103 (18): 2242–7. doi :10.1161/01.cir.103.18.2242 PMID 11342471 . Wistow G, Bernstein SL, Ray S, et al. (2002). "Expressed sequence tag analysis of adult human iris for the NEIBank Project: steroid-response factors and similarities with retinal pigment epithelium". Mol. Vis . 8 : 185–95. PMID 12107412 . Changsirikulchai S, Hudkins KL, Goodpaster TA, et al. (2003). "Platelet-derived growth factor-D expression in developing and mature human kidneys" . Kidney Int . 62 (6): 2043–54. doi :10.1046/j.1523-1755.2002.00662.x PMID 12427128 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Clark HF, Gurney AL, Abaya E, et al. (2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment" . Genome Res . 13 (10): 2265–70. doi :10.1101/gr.1293003 . PMC 403697 PMID 12975309 . Taneda S, Hudkins KL, Topouzis S, et al. (2004). "Obstructive uropathy in mice and humans: potential role for PDGF-D in the progression of tubulointerstitial injury" . J. Am. Soc. Nephrol . 14 (10): 2544–55. doi :10.1097/01.ASN.0000089828.73014.C8 PMID 14514732 . Uutela M, Wirzenius M, Paavonen K, et al. (2004). "PDGF-D induces macrophage recruitment, increased interstitial pressure, and blood vessel maturation during angiogenesis" . Blood . 104 (10): 3198–204. doi :10.1182/blood-2004-04-1485 PMID 15271796 . Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7. doi :10.1101/gr.2596504 . PMC 528928 PMID 15489334 . Ray S, Gao C, Wyatt K, et al. (2005). "Platelet-derived growth factor D, tissue-specific expression in the eye, and a key role in control of lens epithelial cell proliferation" . J. Biol. Chem . 280 (9): 8494–502. doi :10.1074/jbc.M413570200 PMID 15611105 . Ustach CV, Kim HR (2005). "Platelet-Derived Growth Factor D Is Activated by Urokinase Plasminogen Activator in Prostate Carcinoma Cells" . Mol. Cell. Biol . 25 (14): 6279–88. doi :10.1128/MCB.25.14.6279-6288.2005 . PMC 1168822 PMID 15988036 . Liu MY, Eyries M, Zhang C, et al. (2006). "Inducible platelet-derived growth factor D-chain expression by angiotensin II and hydrogen peroxide involves transcriptional regulation by Ets-1 and Sp1" . Blood . 107 (6): 2322–9. doi :10.1182/blood-2005-06-2377 PMID 16189269 .
Angiopoietin CNTF EGF (ErbB)
FGF
FGFR1 FGFR2
Agonists: Ersofermin FGF (1 , 2 (bFGF) , 3 , 4 , 5 , 6 , 7 (KGF ), 8 , 9 , 10 (KGF2) , 17 , 18 , 22 )Palifermin Repifermin Selpercatinib Sprifermin Trafermin FGFR3 FGFR4 Unsorted
HGF (c-Met) IGF
LNGF (p75NTR ) PDGF RET (GFL)
SCF (c-Kit) TGFβ Trk
TrkA
Negative allosteric modulators: VM-902A TrkB
Agonists: 3,7-DHF 3,7,8,2'-THF 4'-DMA-7,8-DHF 7,3'-DHF 7,8-DHF 7,8,2'-THF 7,8,3'-THF Amitriptyline BDNF BNN-20 Deoxygedunin Deprenyl Diosmetin DMAQ-B1 HIOC LM22A-4 N-Acetylserotonin NT-3 NT-4 Norwogonin (5,7,8-THF) R7 R13 TDP6 TrkC
VEGF Others
Additional growth factors: Adrenomedullin Colony-stimulating factors (see here instead)Connective tissue growth factor (CTGF) Ephrins (A1 , A2 , A3 , A4 , A5 , B1 , B2 , B3 )Erythropoietin (see here instead)Glucose-6-phosphate isomerase (GPI; PGI, PHI, AMF) Glia maturation factor (GMF) Hepatoma-derived growth factor (HDGF) Interleukins /T-cell growth factors (see here instead)Leukemia inhibitory factor (LIF) Macrophage-stimulating protein (MSP; HLP, HGFLP) Midkine (NEGF2) Migration-stimulating factor (MSF; PRG4) Oncomodulin Pituitary adenylate cyclase-activating peptide (PACAP) Pleiotrophin Renalase Thrombopoietin (see here instead)Wnt signaling proteins Additional growth factor receptor modulators: Cerebrolysin (neurotrophin mixture)
