THC Science

NTF4
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1HCF, 1B8M, 1B98
Identifiers
Aliases	NTF4, GLC10, GLC1O, NT-4, NT-4/5, NT-5, NT4, NT5, NTF5, neurotrophin 4
External IDs	OMIM: 162662 MGI: 97381 HomoloGene: 4503 GeneCards: NTF4
Gene location (Human)
Chr.	Chromosome 19 (human)
End	49,065,076 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	45,066,603 bp
RNA expression pattern
	Top expressed in
	Top expressed in
	More reference expression data
	n/a
Gene ontology
Molecular function
Cellular component
Biological process
	Sources:Amigo / QuickGO
Orthologs
	4909
	78405
	ENSG00000225950
	ENSMUSG00000074121
	P34130
	Q80VU4
	NM_006179; NM_001395489
	NM_198190
	NP_006170
	NP_937833
	Wikidata
View/Edit Human	View/Edit Mouse

Neurotrophin-4 (NT-4),^[5] also known as neurotrophin-5 (NT-5), is a protein that in humans is encoded by the NTF4 gene.^[6] It is a neurotrophic factor that signals predominantly through the TrkB receptor tyrosine kinase.^[7]^[8] NT-4 was first discovered and isolated from xenopus and viper in the year 1991 by Finn Hallbook et.al^[9]

References[edit]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000225950 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000074121 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Ibáñez CF, Ernfors P, Timmusk T, Ip NY, Arenas E, Yancopoulos GD, Persson H (April 1993). "Neurotrophin-4 is a target-derived neurotrophic factor for neurons of the trigeminal ganglion". Development. 117 (4): 1345–1353. doi:10.1242/dev.117.4.1345. PMID 8404536.
^ "Entrez Gene: neurotrophin 4".
^ Klein R, Lamballe F, Bryant S, Barbacid M (May 1992). "The trkB tyrosine protein kinase is a receptor for neurotrophin-4". Neuron. 8 (5): 947–956. doi:10.1016/0896-6273(92)90209-v. PMID 1375038. S2CID 9772551.
^ Ip NY, Stitt TN, Tapley P, Klein R, Glass DJ, Fandl J, et al. (February 1993). "Similarities and differences in the way neurotrophins interact with the Trk receptors in neuronal and nonneuronal cells". Neuron. 10 (2): 137–149. doi:10.1016/0896-6273(93)90306-c. PMID 7679912. S2CID 46072027.
^ Hallböök F, Ibáñez CF, Persson H (May 1991). "Evolutionary studies of the nerve growth factor family reveal a novel member abundantly expressed in Xenopus ovary". Neuron. 6 (5): 845–858. doi:10.1016/0896-6273(91)90180-8. PMID 2025430. S2CID 17772282.

Further reading[edit]

Childs AJ, Bayne RA, Murray AA, Martins Da Silva SJ, Collins CS, Spears N, Anderson RA (April 2010). "Differential expression and regulation by activin of the neurotrophins BDNF and NT4 during human and mouse ovarian development". Developmental Dynamics. 239 (4): 1211–1219. doi:10.1002/dvdy.22252. PMC 3410523. PMID 20175187.
Vithana EN, Nongpiur ME, Venkataraman D, Chan SH, Mavinahalli J, Aung T (August 2010). "Identification of a novel mutation in the NTF4 gene that causes primary open-angle glaucoma in a Chinese population". Molecular Vision. 16: 1640–1645. PMC 2927376. PMID 20806036.
Truzzi F, Marconi A, Lotti R, Dallaglio K, French LE, Hempstead BL, Pincelli C (August 2008). "Neurotrophins and their receptors stimulate melanoma cell proliferation and migration". The Journal of Investigative Dermatology. 128 (8): 2031–2040. doi:10.1038/jid.2008.21. PMID 18305571.
Harel S, Jin S, Fisch B, Feldberg D, Krissi H, Felz C, et al. (June 2006). "Tyrosine kinase B receptor and its activated neurotrophins in ovaries from human fetuses and adults". Molecular Human Reproduction. 12 (6): 357–365. doi:10.1093/molehr/gal033. PMID 16648150.
Ribasés M, Hervás A, Ramos-Quiroga JA, Bosch R, Bielsa A, Gastaminza X, et al. (May 2008). "Association study of 10 genes encoding neurotrophic factors and their receptors in adult and child attention-deficit/hyperactivity disorder". Biological Psychiatry. 63 (10): 935–945. doi:10.1016/j.biopsych.2007.11.004. PMID 18179783. S2CID 15820930.
Chen ZY, Ieraci A, Teng H, Dall H, Meng CX, Herrera DG, et al. (June 2005). "Sortilin controls intracellular sorting of brain-derived neurotrophic factor to the regulated secretory pathway". The Journal of Neuroscience. 25 (26): 6156–6166. doi:10.1523/JNEUROSCI.1017-05.2005. PMC 1201519. PMID 15987945.
Pasutto F, Matsumoto T, Mardin CY, Sticht H, Brandstätter JH, Michels-Rautenstrauss K, et al. (October 2009). "Heterozygous NTF4 mutations impairing neurotrophin-4 signaling in patients with primary open-angle glaucoma". American Journal of Human Genetics. 85 (4): 447–456. doi:10.1016/j.ajhg.2009.08.016. PMC 2756554. PMID 19765683.
Ibáñez CF (July 1996). "Neurotrophin-4: the odd one out in the neurotrophin family". Neurochemical Research. 21 (7): 787–793. doi:10.1007/BF02532301. PMID 8873083. S2CID 10824679.
Nalbandian A, Pang AL, Rennert OM, Chan WY, Ravindranath N, Djakiew D (October 2005). "A novel function of differentiation revealed by cDNA microarray profiling of p75NTR-regulated gene expression". Differentiation; Research in Biological Diversity. 73 (8): 385–396. doi:10.1111/j.1432-0436.2005.00040.x. PMID 16316409.
Liu Y, Liu W, Crooks K, Schmidt S, Allingham RR, Hauser MA (March 2010). "No evidence of association of heterozygous NTF4 mutations in patients with primary open-angle glaucoma". American Journal of Human Genetics. 86 (3): 498–9, author reply 500. doi:10.1016/j.ajhg.2009.11.018. PMC 2833375. PMID 20215012.
Götz R, Schartl M (May 1994). "The conservation of neurotrophic factors during vertebrate evolution" (PDF). Comparative Biochemistry and Physiology. Pharmacology, Toxicology and Endocrinology. 108 (1): 1–10. doi:10.1016/1367-8280(94)90082-5. PMID 8061955.
Gratacòs M, Escaramís G, Bustamante M, Saus E, Agüera Z, Bayés M, et al. (October 2010). "Role of the neurotrophin network in eating disorders' subphenotypes: body mass index and age at onset of the disease". Journal of Psychiatric Research. 44 (13): 834–840. doi:10.1016/j.jpsychires.2010.01.009. PMID 20219210.
Chakrabarti B, Dudbridge F, Kent L, Wheelwright S, Hill-Cawthorne G, Allison C, et al. (June 2009). "Genes related to sex steroids, neural growth, and social-emotional behavior are associated with autistic traits, empathy, and Asperger syndrome". Autism Research. 2 (3): 157–177. doi:10.1002/aur.80. PMID 19598235. S2CID 18239947.
Mizuno N, Shiba H, Inui T, Takeda K, Kajiya M, Hasegawa N, et al. (November 2008). "Effect of neurotrophin-4/5 on bone/cementum-related protein expressions and DNA synthesis in cultures of human periodontal ligament cells". Journal of Periodontology. 79 (11): 2182–2189. doi:10.1902/jop.2008.070402. PMID 18980528.
Rao KN, Kaur I, Parikh RS, Mandal AK, Chandrasekhar G, Thomas R, Chakrabarti S (October 2010). "Variations in NTF4, VAV2, and VAV3 genes are not involved with primary open-angle and primary angle-closure glaucomas in an indian population". Investigative Ophthalmology & Visual Science. 51 (10): 4937–4941. doi:10.1167/iovs.10-5553. PMID 20463313.
Gratacòs M, Costas J, de Cid R, Bayés M, González JR, Baca-García E, et al. (September 2009). "Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment". American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics. 150B (6): 808–816. doi:10.1002/ajmg.b.30902. PMID 19086053. S2CID 44524739.
Mercader JM, Saus E, Agüera Z, Bayés M, Boni C, Carreras A, et al. (May 2008). "Association of NTRK3 and its interaction with NGF suggest an altered cross-regulation of the neurotrophin signaling pathway in eating disorders". Human Molecular Genetics. 17 (9): 1234–1244. doi:10.1093/hmg/ddn013. hdl:10230/16493. PMID 18203754.
Walz JC, Magalhães PV, Giglio LM, Cunha AB, Stertz L, Fries GR, et al. (April 2009). "Increased serum neurotrophin-4/5 levels in bipolar disorder". Journal of Psychiatric Research. 43 (7): 721–723. doi:10.1016/j.jpsychires.2008.10.005. PMID 19081579. S2CID 7379020.
Prakash YS, Iyanoye A, Ay B, Mantilla CB, Pabelick CM (September 2006). "Neurotrophin effects on intracellular Ca2+ and force in airway smooth muscle". American Journal of Physiology. Lung Cellular and Molecular Physiology. 291 (3): L447–L456. doi:10.1152/ajplung.00501.2005. PMID 16648236.

External links[edit]

neurotrophin+4 at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
neurotrophin+5 at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000225950 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000074121 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] Ibáñez CF, Ernfors P, Timmusk T, Ip NY, Arenas E, Yancopoulos GD, Persson H (April 1993). "Neurotrophin-4 is a target-derived neurotrophic factor for neurons of the trigeminal ganglion". Development. 117 (4): 1345–1353. doi:10.1242/dev.117.4.1345. PMID 8404536.

[entrez-6] "Entrez Gene: neurotrophin 4".

[7] Klein R, Lamballe F, Bryant S, Barbacid M (May 1992). "The trkB tyrosine protein kinase is a receptor for neurotrophin-4". Neuron. 8 (5): 947–956. doi:10.1016/0896-6273(92)90209-v. PMID 1375038. S2CID 9772551.

[8] Ip NY, Stitt TN, Tapley P, Klein R, Glass DJ, Fandl J, et al. (February 1993). "Similarities and differences in the way neurotrophins interact with the Trk receptors in neuronal and nonneuronal cells". Neuron. 10 (2): 137–149. doi:10.1016/0896-6273(93)90306-c. PMID 7679912. S2CID 46072027.

[9] Hallböök F, Ibáñez CF, Persson H (May 1991). "Evolutionary studies of the nerve growth factor family reveal a novel member abundantly expressed in Xenopus ovary". Neuron. 6 (5): 845–858. doi:10.1016/0896-6273(91)90180-8. PMID 2025430. S2CID 17772282.

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Cell signaling: Nervous tissue: Neurotrophic factors
Neurotrophins	NGF BDNF NT-3 NT-4
GDNF family	GDNF Artemin Neurturin Persephin
Ephrins	A1 A2 A3 A4 A5 B1 B2 B3
CNTF family	CNTF LIF IL-6
Other	GMF IGF-1 Neuregulins 1 2 3 4 PACAP VEGF

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