Metizolam

Metizolam
Desmethyletizolam.svg
Clinical data
Dependence
liability
Moderate
Routes of
administration
Oral, sublingual, rectal
Legal status
Legal status
Identifiers
CAS Number
PubChem CID
ChemSpider
Chemical and physical data
Formula C16H13ClN4S
Molar mass 328.82 g/mol g·mol−1
3D model (JSmol)

Metizolam (also known as desmethyletizolam) is a thienotriazolodiazepine that is the demethylated analogue of the closely related etizolam.[1][2][3][4][5][6]

Legal status[edit]

Following its sale as a designer drug,[7] metizolam was classified as controlled substance in Sweden on 26. January 2016.[8]

See also[edit]

References[edit]

  1. ^ Weber, Karl-Heinz; Bauer, Adolf; Langbein, Adolf; Daniel, Helmut (20 September 1978). “Heteroaromaten mit anellierten Siebenringen, III. Umwandlung von Thienotriazolooxazepinen in Diazepine”. Justus Liebigs Annalen der Chemie (in German). 1978 (8): 1257–1265. doi:10.1002/jlac.197819780806. ISSN 1099-0690.
  2. ^ Michio Nakanishi; Tetsuya Tahara; Kazuhiko Araki; Masami Shiroki (9 September 1975). “Patent US 3904641 – Triazolothienodiazepine compounds”.
  3. ^ “Patent EP 0776892 – Thienylazole compound and thienotriazolodiazepine compound”. Yoshitomi Pharmaceutical Industries, Ltd. 4 June 1997.
  4. ^ Minoru Moriwaki; Masao Abe; Hiroshi Mikashima; Tetsuya Tahara (3 March 1993). “Patent EP 0315698 – Thieno(triazolo)diazepine compounds and medicinal application of the same”. Yoshitomi Pharmaceutical Industries, Ltd.
  5. ^ Moosmann, Bjoern; Bisel, Philippe; Franz, Florian; Huppertz, Laura M.; Auwärter, Volker (2016). “Characterization and in vitro phase I microsomal metabolism of designer benzodiazepines – an update comprising adinazolam, cloniprazepam, fonazepam, 3-hydroxyphenazepam, metizolam, and nitrazolam”. Journal of Mass Spectrometry. 51 (11): 1080–1089. doi:10.1002/jms.3840. ISSN 1096-9888. PMID 27535017.
  6. ^ Kintz, Pascal; Richeval, Camille; Jamey, Carole; Ameline, Alice; Allorge, Delphine; Gaulier, Jean-Michel; Raul, Jean-Sébastien (2016). “Detection of the designer benzodiazepine metizolam, in urine and preliminary data on its metabolism”. Drug Testing and Analysis. 9 (7): 1026–1033. doi:10.1002/dta.2099. ISSN 1942-7611. PMID 27671107.
  7. ^ “Desmethyletizolam”. New Synthetic Drugs Database.
  8. ^ “31 nya ämnen kan klassas som narkotika eller hälsofarlig vara” (in Swedish). Folkhälsomyndigheten. November 2015.