Protein-coding gene in humans
Homeobox protein Meis1 is a protein that in humans is encoded by the MEIS1 gene .[3] [4]
Function [ edit ] Homeobox genes, of which the most well-characterized category is represented by the HOX genes, play a crucial role in normal development. In addition, several homeoproteins are involved in neoplasia. This gene encodes a homeobox protein belonging to the TALE ('three amino acid loop extension') family of homeodomain-containing proteins.[4]
Interactions [ edit ] MEIS1 has been shown to interact with PBX1 [5] [6] [7] HOXA9 .[5] [8]
References [ edit ]
^ a b c GRCh38: Ensembl release 89: ENSG00000143995 - Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Moskow JJ, Bullrich F, Huebner K, Daar IO, Buchberg AM (Oct 1995). "Meis1, a PBX1-related homeobox gene involved in myeloid leukemia in BXH-2 mice" . Molecular and Cellular Biology . 15 (10): 5434–43. doi :10.1128/mcb.15.10.5434 . PMC 230793 PMID 7565694 . ^ a b "Entrez Gene: MEIS1 Meis homeobox 1" .^ a b Shen WF, Rozenfeld S, Kwong A, Köm ves LG, Lawrence HJ, Largman C (Apr 1999). "HOXA9 forms triple complexes with PBX2 and MEIS1 in myeloid cells" . Molecular and Cellular Biology . 19 (4): 3051–61. doi :10.1128/mcb.19.4.3051 . PMC 84099 PMID 10082572 . ^ Shanmugam K, Green NC, Rambaldi I, Saragovi HU, Featherstone MS (Nov 1999). "PBX and MEIS as non-DNA-binding partners in trimeric complexes with HOX proteins" . Molecular and Cellular Biology . 19 (11): 7577–88. doi :10.1128/mcb.19.11.7577 . PMC 84774 PMID 10523646 . ^ Jacobs Y, Schnabel CA, Cleary ML (Jul 1999). "Trimeric association of Hox and TALE homeodomain proteins mediates Hoxb2 hindbrain enhancer activity" . Molecular and Cellular Biology . 19 (7): 5134–42. doi :10.1128/mcb.19.7.5134 . PMC 84356 PMID 10373562 . ^ Shen WF, Montgomery JC, Rozenfeld S, Moskow JJ, Lawrence HJ, Buchberg AM, Largman C (Nov 1997). "AbdB-like Hox proteins stabilize DNA binding by the Meis1 homeodomain proteins" . Molecular and Cellular Biology . 17 (11): 6448–58. doi :10.1128/MCB.17.11.6448 . PMC 232497 PMID 9343407 .
Further reading [ edit ]
Allen TD, Zhu YX, Hawley TS, Hawley RG (Oct 2000). "TALE homeoproteins as HOX11-interacting partners in T-cell leukemia". Leukemia & Lymphoma . 39 (3–4): 241–56. doi :10.3109/10428190009065824 . PMID 11342305 . S2CID 27407074 . Bonaldo MF, Lennon G, Soares MB (Sep 1996). "Normalization and subtraction: two approaches to facilitate gene discovery" . Genome Research . 6 (9): 791–806. doi :10.1101/gr.6.9.791 PMID 8889548 . Steelman S, Moskow JJ, Muzynski K, North C, Druck T, Montgomery JC, Huebner K, Daar IO, Buchberg AM (Feb 1997). "Identification of a conserved family of Meis1-related homeobox genes" . Genome Research . 7 (2): 142–56. doi :10.1101/gr.7.2.142 PMID 9049632 . Smith JE, Bollekens JA, Inghirami G, Takeshita K (Jul 1997). "Cloning and mapping of the MEIS1 gene, the human homolog of a murine leukemogenic gene" . Genomics . 43 (1): 99–103. doi :10.1006/geno.1997.4766 PMID 9226379 . Shen WF, Montgomery JC, Rozenfeld S, Moskow JJ, Lawrence HJ, Buchberg AM, Largman C (Nov 1997). "AbdB-like Hox proteins stabilize DNA binding by the Meis1 homeodomain proteins" . Molecular and Cellular Biology . 17 (11): 6448–58. doi :10.1128/MCB.17.11.6448 . PMC 232497 PMID 9343407 . Knoepfler PS, Calvo KR, Chen H, Antonarakis SE, Kamps MP (Dec 1997). "Meis1 and pKnox1 bind DNA cooperatively with Pbx1 utilizing an interaction surface disrupted in oncoprotein E2a-Pbx1" . Proceedings of the National Academy of Sciences of the United States of America . 94 (26): 14553–8. Bibcode :1997PNAS...9414553K . doi :10.1073/pnas.94.26.14553 PMC 25052 PMID 9405651 . Sanger Centre, The; Washington University Genome Sequencing Cente, The (Nov 1998). "Toward a complete human genome sequence" . Genome Research . 8 (11): 1097–108. doi :10.1101/gr.8.11.1097 PMID 9847074 . Shen WF, Rozenfeld S, Kwong A, Köm ves LG, Lawrence HJ, Largman C (Apr 1999). "HOXA9 forms triple complexes with PBX2 and MEIS1 in myeloid cells" . Molecular and Cellular Biology . 19 (4): 3051–61. doi :10.1128/MCB.19.4.3051 . PMC 84099 PMID 10082572 . Jacobs Y, Schnabel CA, Cleary ML (Jul 1999). "Trimeric association of Hox and TALE homeodomain proteins mediates Hoxb2 hindbrain enhancer activity" . Molecular and Cellular Biology . 19 (7): 5134–42. doi :10.1128/MCB.19.7.5134 . PMC 84356 PMID 10373562 . Knoepfler PS, Bergstrom DA, Uetsuki T, Dac-Korytko I, Sun YH, Wright WE, Tapscott SJ, Kamps MP (Sep 1999). "A conserved motif N-terminal to the DNA-binding domains of myogenic bHLH transcription factors mediates cooperative DNA binding with pbx-Meis1/Prep1" . Nucleic Acids Research . 27 (18): 3752–61. doi :10.1093/nar/27.18.3752 . PMC 148632 PMID 10471746 . Shanmugam K, Green NC, Rambaldi I, Saragovi HU, Featherstone MS (Nov 1999). "PBX and MEIS as non-DNA-binding partners in trimeric complexes with HOX proteins" . Molecular and Cellular Biology . 19 (11): 7577–88. doi :10.1128/MCB.19.11.7577 . PMC 84774 PMID 10523646 . Spieker N, van Sluis P, Beitsma M, Boon K, van Schaik BD, van Kampen AH, Caron H, Versteeg R (Jan 2001). "The MEIS1 oncogene is highly expressed in neuroblastoma and amplified in cell line IMR32". Genomics . 71 (2): 214–21. doi :10.1006/geno.2000.6408 . PMID 11161815 . Wang Y, Yin L, Hillgartner FB (Jun 2001). "The homeodomain proteins PBX and MEIS1 are accessory factors that enhance thyroid hormone regulation of the malic enzyme gene in hepatocytes" . The Journal of Biological Chemistry . 276 (26): 23838–48. doi :10.1074/jbc.M102166200 PMID 11331288 . Okada Y, Nagai R, Sato T, Matsuura E, Minami T, Morita I, Doi T (Jun 2003). "Homeodomain proteins MEIS1 and PBXs regulate the lineage-specific transcription of the platelet factor 4 gene" . Blood . 101 (12): 4748–56. doi :10.1182/blood-2002-02-0380 PMID 12609849 . S2CID 6532721 . Zeisig BB, Milne T, García-Cuéllar MP, Schreiner S, Martin ME, Fuchs U, Borkhardt A, Chanda SK, Walker J, Soden R, Hess JL, Slany RK (Jan 2004). "Hoxa9 and Meis1 are key targets for MLL-ENL-mediated cellular immortalization" . Molecular and Cellular Biology . 24 (2): 617–28. doi :10.1128/MCB.24.2.617-628.2004 . PMC 343796 PMID 14701735 . Pineault N, Abramovich C, Ohta H, Humphries RK (Mar 2004). "Differential and common leukemogenic potentials of multiple NUP98-Hox fusion proteins alone or with Meis1" . Molecular and Cellular Biology . 24 (5): 1907–17. doi :10.1128/MCB.24.5.1907-1917.2004 . PMC 350554 PMID 14966272 .
External links [ edit ] This article incorporates text from the United States National Library of Medicine , which is in the public domain .
(1) Basic domains
(1.1) Basic leucine zipper (bZIP )(1.2) Basic helix-loop-helix (bHLH )
Group A Group B Group CPAS Group D Group E Group F
(1.3) bHLH-ZIP (1.4) NF-1 (1.5) RF-X (1.6) Basic helix-span-helix (bHSH)
(2) Zinc finger DNA-binding domains
(2.1) Nuclear receptor (Cys4 )
subfamily 1 subfamily 2 subfamily 3 subfamily 4 subfamily 5 subfamily 6 subfamily 0
(2.2) Other Cys4 (2.3) Cys2 His2 (2.4) Cys6 (2.5) Alternating composition (2.6) WRKY
(4) β-Scaffold factors with minor groove contacts
(0) Other transcription factors
