This is a list of adverse effects of risperidone. Risperidone, sold under the brand name Risperdal among others, is an antipsychotic.[1] It is used to treat schizophrenia, bipolar disorder, and irritability associated with autism.[1]
Common adverse effects[edit]
Common adverse effects of risperidone, occurring greater than or equal to 1%, include:[2][3][4]
- Rash (oral, adults, 1% to 4%; pediatrics, up to 11% ; IM, less than 4%)
- Hyperprolactinaemia (risperidone is probably the most notorious antipsychotic for causing hyperprolactinaemia via its potent blockade of D2 receptors expressed on the lactotrophic cells of the pituitary)[5] (oral, adults, less than 1%; pediatrics, 49% to 87% ; IM, less than 4%)
- Weight gain (causes less weight gain than clozapine, olanzapine and zotepine, around as much weight gain as quetiapine and more weight gain than amisulpride, aripiprazole, lurasidone, asenapine and ziprasidone)[5] (oral, adult, 8.7% to 20.9%; pediatric, 14% to 32.6% ; IM, adult, 8% to 10%)
- Seborrhea
- Constipation (oral, 8% to 21% ; IM, 5% to 7%)
- Diarrhoea (oral, 1% to 8% ; IM, less than 4%)
- Excessive Salivation (oral, 1% to 10% ; IM, 1% to 4%)
- Increased appetite (oral, adult, more than 5%; pediatric, 4% to 47% ; IM, 4%)
- Indigestion (oral, 2% to 10% ; IM, 6%)
- Nausea (oral, 4% to 16% ; IM, 3% to 4%)
- Vomiting (oral, 10% to 25% ; IM, less than 4%)
- Upper abdominal pain (oral, adult, more than 5%; pediatric, 13% to 16%)
- Xerostomia (oral, 4% to 15% ; IM, up to 7%)
- Akathisia (oral, up to 10% ; IM, 4% to 11%)
- Dizziness (oral, 4% to 16% ; IM, 3% to 11%)
- Dyspnoea
- Asthenia
- Agitation
- Urinary incontinence
- Arthralgia
- Myalgia
- Epistaxis
- Somnolence (oral, adult, 3% to 6%; pediatric, 8% to 29% )
- Sleep disturbances
- Major depression, self harm and suicidal thoughts
- Dose-dependent extrapyramidal side effects such as dystonia (oral, adult, 3% to 5%; pediatric, 2% to 6% ; IM, adult, less than 4%), tremor (oral, 2% to 12% ; IM, 3% to 24%) and Parkinsonism (oral, 6% to 28% ; IM, 8% to 15%)
- Blurred vision (oral, 1% to 7% ; IM, 2% to 3%)
- Anxiety (oral, up to 16% IM, less than 4%)
- Cough (oral, adults, 2%; pediatrics, 24% ; IM, 2% to 4%)
- Nasal congestion (oral, adult, 4% to 6%; pediatric, 13%)
- Nasopharyngitis (oral, adult, 3% to 4%; pediatric, 21%)
- Pain in the throat (oral, adult, more than 5%; pediatric, 3% to 10%)
- Upper respiratory tract infection (oral, 2% to 8% ; IM, 2% and 6%)
- Fatigue (oral, adult, 1% to 3%; pediatric, 18% to 42% ; IM, 3% to 9%)
- Generalised pains (IM, 1% to 4%)
- Gynecomastia[6]
- Galactorrhea[7]
- Retrograde ejaculation
Note: The percentage provided next to the adverse effect is the incidence of that adverse effect according to DrugPoint.[2]
[edit]
Rare adverse effects of risperidone, occurring less than 1%, include:[2][3][4]
- Prolonged QT interval
- Sudden cardiac death
- Syncope (oral, up to 1% ; IM, up to 2%)
- Diabetic ketoacidosis
- Hypothermia
- Pancreatitis
- Agranulocytosis
- Neutropenia
- Leukopenia
- Thrombocytopenia
- Thrombotic thrombocytopenic purpura
- Stroke (oral, less than 5% ; IM, less than 4%)
- Seizure (oral, 0.3% ; IM, 0.3%)
- Tardive dyskinesia (oral, less than 5% ; IM, less than 4%)
- Priapism
- Pulmonary embolism
- Neuroleptic malignant syndrome (oral, adults, less than 1%; pediatrics, less than 5%)
- Anorexia
- Hypoaesthesia
- Impaired concentration
- Sexual dysfunction
- Angioedema
- Intestinal obstruction
- Megacolon
- Oedema
- Hyponatraemia
Note: The percentage provided next to the adverse effect is the incidence of that adverse effect according to DrugPoint.[2]
References[edit]
- ^ a b "Risperidone". The American Society of Health-System Pharmacists. Archived from the original on 2015-12-02. Retrieved Dec 1, 2015.
- ^ a b c d Truven Health Analytics, Inc. DrugPoint® System (Internet) [cited 2013 Sep 18]. Greenwood Village, CO: Thomsen Healthcare; 2013.
- ^ a b Joint Formulary Committee. British National Formulary (BNF) 65. Pharmaceutical Pr; 2013.
- ^ a b Australian Medicines Handbook 2013 [Internet]. Australian Medicines Handbook Pty. Limited; 2013. Available from: https://www.amh.net.au/online/auth?timeout&page=index.php
- ^ a b Leucht, S; Cipriani, A; Spineli, L; Mavridis, D; Örey, D; Richter, F; et al. (Sep 2013). "Comparative efficacy and tolerability of 15 antipsychotic drugs in schizophrenia: a multiple-treatments meta-analysis". The Lancet. 382 (9896): 951–62. doi:10.1016/S0140-6736(13)60733-3. PMID 23810019. S2CID 32085212.
- ^ "Gynecomastia and Risperdal - Causes & Symptoms".
- ^ Peitl, M. V.; Peitl, V.; Grahovac, T.; Pavlović, E. (Mar 2010). "Galactorrhea - side effect of risperidone in combination with depakine chrono in a patient with bipolar disorder". Psychiatr Danub. 22 (1): 125–7. PMID 20305608.