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KCNK7
Identifiers
Aliases	KCNK7, K2p7.1, TWIK3, potassium two pore domain channel subfamily K member 7
External IDs	OMIM: 603940 MGI: 1341841 HomoloGene: 43131 GeneCards: KCNK7
Gene location (Human)
Chr.	Chromosome 11 (human)
End	65,595,996 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	5,757,137 bp
RNA expression pattern
	Top expressed in
	Top expressed in
	More reference expression data
	n/a
Gene ontology
Molecular function
Cellular component
Biological process
	Sources:Amigo / QuickGO
Orthologs
	10089
	16530
	ENSG00000173338
	ENSMUSG00000024936
	Q9Y2U2
	Q9Z2T1
	NM_033456; NM_005714; NM_033347; NM_033348; NM_033455
	NM_001004138; NM_010609
	NP_005705; NP_203133; NP_203134; NP_258416
	NP_034739
	Wikidata
View/Edit Human	View/Edit Mouse

Potassium channel, subfamily K, member 7, also known as KCNK7 or K_2P7.1 is a protein which is encoded in humans by the KCNK7 gene. K_2P7.1 is a potassium channel containing two pore-forming P domains.^[5]^[6]^[7] Multiple transcript variants encoding different isoforms have been found for this gene.^[8]

Function[edit]

This gene encodes a member of the superfamily of potassium channel proteins containing two pore-forming P domains. The product of this gene has not been shown to be a functional channel; It may require other non-pore-forming proteins for activity.^[8]

References[edit]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000173338 - Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000024936 - Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Salinas M, Reyes R, Lesage F, Fosset M, Heurteaux C, Romey G, Lazdunski M (April 1999). "Cloning of a new mouse two-P domain channel subunit and a human homologue with a unique pore structure". J. Biol. Chem. 274 (17): 11751–60. doi:10.1074/jbc.274.17.11751. PMID 10206991.
^ Goldstein SA, Bockenhauer D, O'Kelly I, Zilberberg N (March 2001). "Potassium leak channels and the KCNK family of two-P-domain subunits". Nat. Rev. Neurosci. 2 (3): 175–84. doi:10.1038/35058574. PMID 11256078. S2CID 9682396.
^ Goldstein SA, Bayliss DA, Kim D, Lesage F, Plant LD, Rajan S (December 2005). "International Union of Pharmacology. LV. Nomenclature and molecular relationships of two-P potassium channels". Pharmacol. Rev. 57 (4): 527–40. doi:10.1124/pr.57.4.12. PMID 16382106. S2CID 7356601.
^ ^a ^b "Entrez Gene: potassium channel".

External links[edit]

KCNK7+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
KCNK7 human gene location in the UCSC Genome Browser.
KCNK7 human gene details in the UCSC Genome Browser.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000173338 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000024936 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10206991-5] Salinas M, Reyes R, Lesage F, Fosset M, Heurteaux C, Romey G, Lazdunski M (April 1999). "Cloning of a new mouse two-P domain channel subunit and a human homologue with a unique pore structure". J. Biol. Chem. 274 (17): 11751–60. doi:10.1074/jbc.274.17.11751. PMID 10206991.

[pmid11256078-6] Goldstein SA, Bockenhauer D, O'Kelly I, Zilberberg N (March 2001). "Potassium leak channels and the KCNK family of two-P-domain subunits". Nat. Rev. Neurosci. 2 (3): 175–84. doi:10.1038/35058574. PMID 11256078. S2CID 9682396.

[pmid16382106-7] Goldstein SA, Bayliss DA, Kim D, Lesage F, Plant LD, Rajan S (December 2005). "International Union of Pharmacology. LV. Nomenclature and molecular relationships of two-P potassium channels". Pharmacol. Rev. 57 (4): 527–40. doi:10.1124/pr.57.4.12. PMID 16382106. S2CID 7356601.

[entrez-8] "Entrez Gene: potassium channel".

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Function[edit]

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