THC Science

INTS6
Identifiers
Aliases	INTS6, DBI-1, DDX26, DDX26A, DICE1, HDB, INT6, Notchl2, integrator complex subunit 6
External IDs	OMIM: 604331 MGI: 1202397 HomoloGene: 8121 GeneCards: INTS6
Gene location (Human)
Chr.	Chromosome 13 (human)
End	51,454,264 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	62,998,618 bp
RNA expression pattern
	Top expressed in
	Top expressed in
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function
Cellular component
Biological process
	Sources:Amigo / QuickGO
Orthologs
	26512
	18130
	ENSG00000102786
	ENSMUSG00000035161
	Q9UL03
	Q6PCM2
	NM_001039937; NM_001039938; NM_001306091; NM_012141
	NM_008715
	NP_001035026; NP_001035027; NP_001293020; NP_036273
	NP_032741
	Wikidata
View/Edit Human	View/Edit Mouse

Integrator complex subunit 6 is a protein that in humans is encoded by the INTS6 gene.^[5]^[6]^[7]

DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. The protein encoded by this gene is a DEAD box protein that is part of a complex that interacts with the C-terminus of RNA polymerase II and is involved in 3' end processing of snRNAs. In addition, this gene is a candidate tumor suppressor and located in the critical region of loss of heterozygosity (LOH). Three transcript variants encoding two different isoforms have been found for this gene.^[7]

References[edit]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000102786 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000035161 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Wieland I, Arden KC, Michels D, Klein-Hitpass L, Bohm M, Viars CS, Weidle UH (Oct 1999). "Isolation of DICE1: a gene frequently affected by LOH and downregulated in lung carcinomas". Oncogene. 18 (32): 4530–7. doi:10.1038/sj.onc.1202806. PMID 10467397.
^ Baillat D, Hakimi MA, Naar AM, Shilatifard A, Cooch N, Shiekhattar R (Oct 2005). "Integrator, a multiprotein mediator of small nuclear RNA processing, associates with the C-terminal repeat of RNA polymerase II". Cell. 123 (2): 265–76. doi:10.1016/j.cell.2005.08.019. PMID 16239144.
^ ^a ^b "Entrez Gene: INTS6 integrator complex subunit 6".

Further reading[edit]

Buchsbaum S, Morris C, Bochard V, Jalinot P (2007). "Human INT6 interacts with MCM7 and regulates its stability during S phase of the cell cycle". Oncogene. 26 (35): 5132–44. doi:10.1038/sj.onc.1210314. PMID 17310990. S2CID 2886919.
Hernández M, Papadopoulos N, Almeida TA (2006). "Absence of mutations in DICE1/DDX26 gene in human cancer cell lines with frequent 13q14 deletions". Cancer Genet. Cytogenet. 163 (1): 91–2. doi:10.1016/j.cancergencyto.2005.04.014. PMID 16271964.
Röpke A, Buhtz P, Böhm M, et al. (2005). "Promoter CpG hypermethylation and downregulation of DICE1 expression in prostate cancer". Oncogene. 24 (44): 6667–75. doi:10.1038/sj.onc.1208824. PMID 16007164. S2CID 12129480.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Wieland I, Sell C, Weidle UH, Wieacker P (2005). "Ectopic expression of DICE1 suppresses tumor cell growth". Oncol. Rep. 12 (2): 207–11. doi:10.3892/or.12.2.207. PMID 15254679.
Dunham A, Matthews LH, Burton J, et al. (2004). "The DNA sequence and analysis of human chromosome 13". Nature. 428 (6982): 522–8. Bibcode:2004Natur.428..522D. doi:10.1038/nature02379. PMC 2665288. PMID 15057823.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Li WJ, Hu N, Su H, et al. (2003). "Allelic loss on chromosome 13q14 and mutation in deleted in cancer 1 gene in esophageal squamous cell carcinoma". Oncogene. 22 (2): 314–8. doi:10.1038/sj.onc.1206098. PMID 12527901. S2CID 10839440.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Wieland I, Röpke A, Stumm M, et al. (2002). "Molecular characterization of the DICE1 (DDX26) tumor suppressor gene in lung carcinoma cells". Oncol. Res. 12 (11–12): 491–500. doi:10.3727/096504001108747503. PMID 11939413.
Camargo AA, Nunes DN, Samaia HB, et al. (2002). "Molecular characterization of DDX26, a human DEAD-box RNA helicase, located on chromosome 7p12". Braz. J. Med. Biol. Res. 34 (10): 1237–45. doi:10.1590/s0100-879x2001001000002. PMID 11593297.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000102786 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000035161 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10467397-5] Wieland I, Arden KC, Michels D, Klein-Hitpass L, Bohm M, Viars CS, Weidle UH (Oct 1999). "Isolation of DICE1: a gene frequently affected by LOH and downregulated in lung carcinomas". Oncogene. 18 (32): 4530–7. doi:10.1038/sj.onc.1202806. PMID 10467397.

[pmid16239144-6] Baillat D, Hakimi MA, Naar AM, Shilatifard A, Cooch N, Shiekhattar R (Oct 2005). "Integrator, a multiprotein mediator of small nuclear RNA processing, associates with the C-terminal repeat of RNA polymerase II". Cell. 123 (2): 265–76. doi:10.1016/j.cell.2005.08.019. PMID 16239144.

[entrez-7] "Entrez Gene: INTS6 integrator complex subunit 6".

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