Protein-coding gene in the species Homo sapiens
Growth factor receptor-bound protein 10 also known as insulin receptor-binding protein Grb-IR is a protein that in humans is encoded by the GRB10 gene .[5] [6] [7] [8]
Function [ edit ] The product of this gene belongs to a small family of adaptor proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with insulin receptors and insulin-like growth-factor receptors (e.g., IGF1R and IGF2R ). Overexpression of some isoforms of the encoded protein inhibits tyrosine kinase activity and results in growth suppression. This gene is imprinted in a highly isoform- and tissue-specific manner. Alternatively spliced transcript variants encoding different isoforms have been identified.[5]
Animal studies [ edit ] Mice whose paternally inherited Grb10 gene is inactivated are more aggressive while those whose maternally inherited allele is inactivated exhibit foetal overgrowth and are significantly bigger than wild-type litter-mates.[9]
Interactions [ edit ] GRB10 has been shown to interact with
References [ edit ]
^ a b c GRCh38: Ensembl release 89: ENSG00000106070 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000020176 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ a b "Entrez Gene: GRB10 growth factor receptor-bound protein 10" .^ Jerome CA, Scherer SW, Tsui LC, Gietz RD, Triggs-Raine B (February 1997). "Assignment of growth factor receptor-bound protein 10 (GRB10) to human chromosome 7p11.2-p12". Genomics . 40 (1): 215–6. doi :10.1006/geno.1996.4535 . PMID 9070953 . ^ Dong LQ, Du H, Porter SG, Kolakowski LF, Lee AV, Mandarino LJ, Fan J, Yee D, Liu F, Mandarino J (November 1997). "Cloning, chromosome localization, expression, and characterization of an Src homology 2 and pleckstrin homology domain-containing insulin receptor binding protein hGrb10gamma" . J. Biol. Chem . 272 (46): 29104–12. doi :10.1074/jbc.272.46.29104 PMID 9360986 . ^ Monk D, Arnaud P, Frost J, Hills FA, Stanier P, Feil R, Moore GE (August 2009). "Reciprocal imprinting of human GRB10 in placental trophoblast and brain: evolutionary conservation of reversed allelic expression" . Hum. Mol. Genet . 18 (16): 3066–74. doi :10.1093/hmg/ddp248 PMID 19487367 . ^ Garfield AS, Cowley M, Smith FM, Moorwood K, Stewart-Cox JE, Gilroy K, Baker S, Xia J, Dalley JW, Hurst LD, Wilkinson LS, Isles AR, Ward A (2011). "Distinct physiological and behavioural functions for parental alleles of imprinted Grb10" . Nature . 469 (7331): 534–538. Bibcode :2011Natur.469..534G . doi :10.1038/nature09651 . PMC 3031026 PMID 21270893 . Bhanoo SN (January 27, 2011). "Altering a Mouse Gene Turns Up Aggression, Study Says" . New York Times . ^ a b Bai RY, Jahn T, Schrem S, Munzert G, Weidner KM, Wang JY, Duyster J (August 1998). "The SH2-containing adapter protein GRB10 interacts with BCR-ABL" . Oncogene . 17 (8): 941–8. doi :10.1038/sj.onc.1202024 PMID 9747873 . ^ a b Frantz JD, Giorgetti-Peraldi S, Ottinger EA, Shoelson SE (January 1997). "Human GRB-IRbeta/GRB10. Splice variants of an insulin and growth factor receptor-binding protein with PH and SH2 domains" . J Biol Chem . 272 (5): 2659–67. doi :10.1074/jbc.272.5.2659 PMID 9006901 . ^ Nantel A, Huber M, Thomas DY (December 1999). "Localization of endogenous Grb10 to the mitochondria and its interaction with the mitochondrial-associated Raf-1 pool" . J Biol Chem . 274 (50): 35719–24. doi :10.1074/jbc.274.50.35719 PMID 10585452 . ^ a b Nantel A, Mohammad-Ali K, Sherk J, Posner BI, Thomas DY (April 1998). "Interaction of the Grb10 adapter protein with the Raf1 and MEK1 kinases" . J Biol Chem . 273 (17): 10475–84. doi :10.1074/jbc.273.17.10475 PMID 9553107 . ^ Jahn T, Seipel P, Urschel S, Peschel C, Duyster J (February 2002). "Role for the adaptor protein Grb10 in the activation of Akt" . Mol Cell Biol . 22 (4): 979–91. doi :10.1128/MCB.22.4.979-991.2002 . PMC 134632 PMID 11809791 . ^ Langlais P, Dong LQ, Hu D, Liu F (June 2000). "Identification of Grb10 as a direct substrate for members of the Src tyrosine kinase family" . Oncogene . 19 (25): 2895–903. doi :10.1038/sj.onc.1203616 PMID 10871840 . ^ Hansen H, Svensson U, Zhu J, Laviola L, Giorgino F, Wolf G, Smith RJ, Riedel H (April 1996). "Interaction between the Grb10 SH2 domain and the insulin receptor carboxyl terminus" . J Biol Chem . 271 (15): 8882–6. doi :10.1074/jbc.271.15.8882 PMID 8621530 . ^ Liu F, Roth RA (October 1995). "Grb-IR: a SH2-domain-containing protein that binds to the insulin receptor and inhibits its function" . Proc Natl Acad Sci U S A . 92 (22): 10287–91. Bibcode :1995PNAS...9210287L . doi :10.1073/pnas.92.22.10287 PMC 40781 PMID 7479769 . ^ a b He W, Rose DW, Olefsky JM, Gustafson TA (March 1998). "Grb10 interacts differentially with the insulin receptor, insulin-like growth factor I receptor, and epidermal growth factor receptor via the Grb10 Src homology 2 (SH2) domain and a second novel domain located between the pleckstrin homology and SH2 domains" . J Biol Chem . 273 (12): 6860–7. doi :10.1074/jbc.273.12.6860 PMID 9506989 . ^ Vecchione A, Marchese A, Henry P, Rotin D, Morrione A (May 2003). "The Grb10/Nedd4 complex regulates ligand-induced ubiquitination and stability of the insulin-like growth factor I receptor" . Mol Cell Biol . 23 (9): 3363–72. doi :10.1128/MCB.23.9.3363-3372.2003 . PMC 153198 PMID 12697834 . ^ Dey BR, Frick K, Lopaczynski W, Nissley SP, Furlanetto RW (June 1996). "Evidence for the direct interaction of the insulin-like growth factor I receptor with IRS-1, Shc, and Grb10" . Mol Endocrinol . 10 (6): 631–41. doi :10.1210/mend.10.6.8776723 PMID 8776723 . ^ Morrione A, Valentinis B, Li S, Ooi JY, Margolis B, Baserga R (July 1996). "Grb10: A new substrate of the insulin-like growth factor I receptor". Cancer Res . 56 (14): 3165–7. PMID 8764099 . ^ Pandey A, Duan H, Di Fiore PP, Dixit VM (September 1995). "The Ret receptor protein tyrosine kinase associates with the SH2-containing adapter protein Grb10" . J Biol Chem . 270 (37): 21461–3. doi :10.1074/jbc.270.37.21461 PMID 7665556 .
Further reading [ edit ]
Ramírez-Dueñas ML, Medina C, Ocampo-Campos R, Rivera H (1992). "Severe Silver-Russell syndrome and translocation (17;20) (q25;q13)". Clin. Genet . 41 (1): 51–3. doi :10.1111/j.1399-0004.1992.tb03630.x . PMID 1633648 . S2CID 28801507 . Liu F, Roth RA (1995). "Grb-IR: a SH2-domain-containing protein that binds to the insulin receptor and inhibits its function" . Proc. Natl. Acad. Sci. U.S.A . 92 (22): 10287–91. Bibcode :1995PNAS...9210287L . doi :10.1073/pnas.92.22.10287 PMC 40781 PMID 7479769 . Pandey A, Duan H, Di Fiore PP, Dixit VM (1995). "The Ret receptor protein tyrosine kinase associates with the SH2-containing adapter protein Grb10" . J. Biol. Chem . 270 (37): 21461–3. doi :10.1074/jbc.270.37.21461 PMID 7665556 . Midro AT, Debek K, Sawicka A, et al. (1993). "Second observation of Silver-Russel syndrome in a carrier of a reciprocal translocation with one breakpoint at site 17q25". Clin. Genet . 44 (1): 53–5. doi :10.1111/j.1399-0004.1993.tb03845.x . PMID 8403458 . S2CID 20766311 . Hansen H, Svensson U, Zhu J, et al. (1996). "Interaction between the Grb10 SH2 domain and the insulin receptor carboxyl terminus" . J. Biol. Chem . 271 (15): 8882–6. doi :10.1074/jbc.271.15.8882 PMID 8621530 . Morrione A, Valentinis B, Li S, et al. (1996). "Grb10: A new substrate of the insulin-like growth factor I receptor". Cancer Res . 56 (14): 3165–7. PMID 8764099 . O'Neill TJ, Rose DW, Pillay TS, et al. (1996). "Interaction of a GRB-IR splice variant (a human GRB10 homolog) with the insulin and insulin-like growth factor I receptors. Evidence for a role in mitogenic signaling" . J. Biol. Chem . 271 (37): 22506–13. doi :10.1074/jbc.271.37.22506 PMID 8798417 . Stein E, Cerretti DP, Daniel TO (1996). "Ligand activation of ELK receptor tyrosine kinase promotes its association with Grb10 and Grb2 in vascular endothelial cells" . J. Biol. Chem . 271 (38): 23588–93. doi :10.1074/jbc.271.38.23588 PMID 8798570 . Frantz JD, Giorgetti-Peraldi S, Ottinger EA, Shoelson SE (1997). "Human GRB-IRbeta/GRB10. Splice variants of an insulin and growth factor receptor-binding protein with PH and SH2 domains" . J. Biol. Chem . 272 (5): 2659–67. doi :10.1074/jbc.272.5.2659 PMID 9006901 . Nagase T, Seki N, Ishikawa K, et al. (1997). "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain" . DNA Res . 3 (5): 321–9, 341–54. doi :10.1093/dnares/3.5.321 PMID 9039502 . He W, Rose DW, Olefsky JM, Gustafson TA (1998). "Grb10 interacts differentially with the insulin receptor, insulin-like growth factor I receptor, and epidermal growth factor receptor via the Grb10 Src homology 2 (SH2) domain and a second novel domain located between the pleckstrin homology and SH2 domains" . J. Biol. Chem . 273 (12): 6860–7. doi :10.1074/jbc.273.12.6860 PMID 9506989 . Nantel A, Mohammad-Ali K, Sherk J, et al. (1998). "Interaction of the Grb10 adapter protein with the Raf1 and MEK1 kinases" . J. Biol. Chem . 273 (17): 10475–84. doi :10.1074/jbc.273.17.10475 PMID 9553107 . Moutoussamy S, Renaudie F, Lago F, et al. (1998). "Grb10 identified as a potential regulator of growth hormone (GH) signaling by cloning of GH receptor target proteins" . J. Biol. Chem . 273 (26): 15906–12. doi :10.1074/jbc.273.26.15906 PMID 9632636 . Bai RY, Jahn T, Schrem S, et al. (1998). "The SH2-containing adapter protein GRB10 interacts with BCR-ABL" . Oncogene . 17 (8): 941–8. doi :10.1038/sj.onc.1202024 PMID 9747873 . Mano H, Ohya K, Miyazato A, et al. (1998). "Grb10/GrbIR as an in vivo substrate of Tec tyrosine kinase" . Genes Cells . 3 (7): 431–41. doi :10.1046/j.1365-2443.1998.00201.x PMID 9753425 . S2CID 6391234 . Washington University Genome Sequencing Cente (November 1998). "Toward a complete human genome sequence" . Genome Res . 8 (11): 1097–108. doi :10.1101/gr.8.11.1097 PMID 9847074 . Angrist M, Bolk S, Bentley K, et al. (1999). "Genomic structure of the gene for the SH2 and pleckstrin homology domain-containing protein GRB10 and evaluation of its role in Hirschsprung disease" . Oncogene . 17 (23): 3065–70. doi :10.1038/sj.onc.1202226 PMID 9881709 . Wang J, Dai H, Yousaf N, et al. (1999). "Grb10, a positive, stimulatory signaling adapter in platelet-derived growth factor BB-, insulin-like growth factor I-, and insulin-mediated mitogenesis" . Mol. Cell. Biol . 19 (9): 6217–28. doi :10.1128/MCB.19.9.6217 . PMC 84567 PMID 10454568 .
External links [ edit ]
This article incorporates text from the United States National Library of Medicine , which is in the public domain .
