Fursultiamine

Clinical data
AHFS/Drugs.com	International Drug Names
Routes of administration	Oral
ATC code	None
Legal status
Legal status	In general: Over-the-counter (OTC)
Identifiers
IUPAC name N-[(4-Amino-2-methylpyrimidin-5-yl)methyl]-N-{(1E)-4-hydroxy-1-methyl-2-[(tetrahydrofuran-2-ylmethyl)disulfanyl]but-1-en-1-yl}formamide
CAS Number	804-30-8
PubChem CID	3002119
DrugBank	DB08966 N
ChemSpider	2273321
UNII	05J61265PX
ChEMBL	ChEMBL1740659
CompTox Dashboard (EPA)	DTXSID0023084
ECHA InfoCard	100.011.234
Chemical and physical data
Formula	C17H26N4O3S2
Molar mass	398.54 g·mol−1
3D model (JSmol)	Interactive image
SMILES O=CN(\C(=C(\SSCC1OCCC1)CCO)C)Cc2cnc(nc2N)C

Fursultiamine (INN; chemical name thiamine tetrahydrofurfuryl disulfide or TTFD; brand names Adventan, Alinamin-F, Benlipoid, Bevitol Lipophil, Judolor, Lipothiamine) is a medication and vitamin used to treat thiamine deficiency. Chemically, it is a disulfide derivative of thiamine and is similar in structure to allithiamine.^[1]

It was synthesized in Japan in the 1960s from allithiamine for the purpose of developing forms of thiamine with improved lipophilicity for treating vitamin B₁ deficiency (i.e., beriberi),^[1] It was subsequently commercialized not only in Japan but also in Spain, Austria, Germany, and the United States.^[2]

See also[edit]

• Vitamin B₁ analogue

References[edit]

Further reading[edit]

• Lonsdale D (September 2004). "Thiamine tetrahydrofurfuryl disulfide: a little known therapeutic agent". Medical Science Monitor. 10 (9): RA199–203. PMID 15328496.