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EGR3
Identifiers
Aliases	EGR3, EGR-3, PILOT, early growth response 3
External IDs	OMIM: 602419 MGI: 1306780 HomoloGene: 37923 GeneCards: EGR3
Gene location (Human)
Chr.	Chromosome 8 (human)
End	22,693,480 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	70,320,063 bp
RNA expression pattern
	Top expressed in
	Top expressed in
	More reference expression data
	More reference expression data
Gene ontology
Molecular function
Cellular component
Biological process
	Sources:Amigo / QuickGO
Orthologs
	1960
	13655
	ENSG00000179388
	ENSMUSG00000033730
	Q06889
	P43300
	NM_001199880; NM_001199881; NM_004430
	NM_001289925; NM_001289927; NM_018781
	NP_001186809; NP_001186810; NP_004421
	NP_001276854; NP_001276856; NP_061251
	Wikidata
View/Edit Human	View/Edit Mouse

Early growth response protein 3 is a protein in humans, encoded by the EGR3 gene.^[5]^[6]^[7]

The gene encodes a transcriptional regulator that belongs to the EGR family of C2H2-type zinc-finger proteins. It is an immediate-early growth response gene which is induced by mitogenic stimulation. The protein encoded by this gene participates in the transcriptional regulation of genes in controlling biological rhythm. It may also play a role in muscle development.^[7]

References[edit]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000179388 - Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000033730 - Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Patwardhan S, Gashler A, Siegel MG, Chang LC, Joseph LJ, Shows TB, Le Beau MM, Sukhatme VP (Aug 1991). "EGR3, a novel member of the Egr family of genes encoding immediate-early transcription factors". Oncogene. 6 (6): 917–28. PMID 1906159.
^ Yang Y, Dong B, Mittelstadt PR, Xiao H, Ashwell JD (May 2002). "HIV Tat binds Egr proteins and enhances Egr-dependent transactivation of the Fas ligand promoter". J Biol Chem. 277 (22): 19482–19487. doi:10.1074/jbc.M201687200. PMID 11909874.
^ ^a ^b "Entrez Gene: EGR3 early growth response 3".

Further reading[edit]

Yamada K, Gerber DJ, Iwayama Y, et al. (2007). "Genetic analysis of the calcineurin pathway identifies members of the EGR gene family, specifically EGR3, as potential susceptibility candidates in schizophrenia". Proc. Natl. Acad. Sci. U.S.A. 104 (8): 2815–2820. doi:10.1073/pnas.0610765104. PMC 1815264. PMID 17360599.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Yoo YG, Lee MO (2004). "Hepatitis B virus X protein induces expression of Fas ligand gene through enhancing transcriptional activity of early growth response factor". J. Biol. Chem. 279 (35): 36242–36249. doi:10.1074/jbc.M401290200. PMID 15173177.
Inoue A, Omoto Y, Yamaguchi Y, et al. (2005). "Transcription factor EGR3 is involved in the estrogen-signaling pathway in breast cancer cells". J. Mol. Endocrinol. 32 (3): 649–661. doi:10.1677/jme.0.0320649. PMID 15171706.
Liu D, Jia H, Holmes DI, et al. (2004). "Vascular endothelial growth factor-regulated gene expression in endothelial cells: KDR-mediated induction of Egr3 and the related nuclear receptors Nur77, Nurr1, and Nor1". Arterioscler. Thromb. Vasc. Biol. 23 (11): 2002–2007. doi:10.1161/01.ATV.0000098644.03153.6F. PMID 14525795.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Tourtellotte WG, Milbrandt J (1998). "Sensory ataxia and muscle spindle agenesis in mice lacking the transcription factor Egr3". Nat. Genet. 20 (1): 87–91. doi:10.1038/1757. PMID 9731539. S2CID 5707748.
Morris ME, Viswanathan N, Kuhlman S, et al. (1998). "A screen for genes induced in the suprachiasmatic nucleus by light". Science. 279 (5356): 1544–1547. Bibcode:1998Sci...279.1544M. doi:10.1126/science.279.5356.1544. PMID 9488654.
Hillier LD, Lennon G, Becker M, et al. (1997). "Generation and analysis of 280,000 human expressed sequence tags". Genome Res. 6 (9): 807–828. doi:10.1101/gr.6.9.807. PMID 8889549.
Mages HW, Stamminger T, Rilke O, et al. (1993). "Expression of PILOT, a putative transcription factor, requires two signals and is cyclosporin A sensitive in T cells". Int. Immunol. 5 (1): 63–70. doi:10.1093/intimm/5.1.63. PMID 8443122.

External links[edit]

EGR3+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000179388 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000033730 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1906159-5] Patwardhan S, Gashler A, Siegel MG, Chang LC, Joseph LJ, Shows TB, Le Beau MM, Sukhatme VP (Aug 1991). "EGR3, a novel member of the Egr family of genes encoding immediate-early transcription factors". Oncogene. 6 (6): 917–28. PMID 1906159.

[pmid11909874-6] Yang Y, Dong B, Mittelstadt PR, Xiao H, Ashwell JD (May 2002). "HIV Tat binds Egr proteins and enhances Egr-dependent transactivation of the Fas ligand promoter". J Biol Chem. 277 (22): 19482–19487. doi:10.1074/jbc.M201687200. PMID 11909874.

[entrez-7] "Entrez Gene: EGR3 early growth response 3".

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