Cloniprazepam

Cloniprazepam
Cloniprazepam.svg
Clinical data
Synonyms1-Cyclopropylmethylclonazepam, Kloniprazepam, 2-Chloro-7'-nitroprazepam
Drug classBenzodiazepines
Legal status
Legal status
Identifiers
CAS Number
ChemSpider
Chemical and physical data
FormulaC19H16ClN3O3
Molar mass369.802 g/mol g·mol−1
3D model (JSmol)
Metabolic pathway of cloniprazepam

Cloniprazepam is a benzodiazepine derivative and a prodrug mainly for clonazepam (a patented medicine) and other metabolites.,[1][2] including 7-aminoclonazepam and clonazepam mentioned above (both as metabolites), which may be misinterpreted as clonazepam intake at the result of a drug test.[1]

Some of the minor metabolites include 3-hydroxy and 6-hydroxyclonazepam, 3-hydroxycloniprazepam and ketocloniprazepam with ketone group formed where 3-hydroxy group was.[1]

It is a designer drug and an NPS (short for "new psychoactive substance").[1] At the end of 2017, cloniprazepam remains an uncontrolled substance in most of the countries.

See also[edit]

References[edit]

  1. ^ a b c d Moosmann, Bjoern; Bisel, Philippe; Franz, Florian; Huppertz, Laura M.; Auwärter, Volker (November 2016). "Characterization and in vitro phase I microsomal metabolism of designer benzodiazepines — an update comprising adinazolam, cloniprazepam, fonazepam, 3-hydroxyphenazepam, metizolam and nitrazolam". Journal of Mass Spectrometry. 51 (11): 1080–1089. doi:10.1002/jms.3840. ISSN 1096-9888. PMID 27535017.
  2. ^ Mortelé, O.; Vervliet, P.; Gys, C.; Degreef, M.; Cuykx, M.; Maudens, K.; Covaci, A.; van Nuijs ALN; Lai, F. Y. (2018). "In vitro Phase I and Phase II metabolism of the new designer benzodiazepine cloniprazepam using liquid chromatography coupled to quadrupole time-of-flight mass spectrometry". Journal of Pharmaceutical and Biomedical Analysis. 153: 158–167. doi:10.1016/j.jpba.2018.02.032. ISSN 0731-7085. PMID 29494888.

External links[edit]