Class C GPCR
|7 transmembrane receptor (metabotropic glutamate family)|
The class C G-protein-coupled receptors (InterPro: IPR000337) are a class of G-protein coupled receptors that include the metabotropic glutamate receptors (InterPro: IPR000162) and several additional receptors.
Structurally they are composed of four elements; an N-terminal signal sequence; a large hydrophilic extracellular agonist-binding region containing several conserved cysteine residues which could be involved in disulphide bonds; a shorter region containing seven transmembrane domains; and a C-terminal cytoplasmic domain of variable length. This protein family includes metabotropic glutamate receptors, the extracellular calcium-sensing receptors, the gamma-amino-butyric acid (GABA) type B receptors, and the vomeronasal type-2 receptors.
- extracellular calcium-sensing receptor-related InterPro: IPR000068
- GABAB receptor (gamma-aminobutyric acid) InterPro: IPR002455
Metabotropic glutamate receptors
- Metabotropic glutamate receptors (mGluR) InterPro: IPR000162
- Retinoic acid-inducible orphan G protein-coupled receptors (RAIG)
- Taste receptor